Institution
University of Debrecen
Recent research
- Climate & EnvironmentOpen access
This repository contains the complete simulation code and datasets supporting the manuscript "Quantifying Dryland Niche Space and Spatial Connectivity Under Climate Forcing: A Hybrid AI–Mechanistic Ensemble Approach." The package includes an AI-enhanced mechanistic ensemble biodi...
- Health & MedicineOpen access
BACKGROUND: This first part of the S2k guidelines is an update of the 2015 S1 European guidelines based on the structured assessment of clinically relevant topics by the panel of experts. It is complemented by Part 2, which deals with treatments. OBJECTIVES: These guidelines aim...
- BiologyOpen access
Social communication during a sow-piglet foraging paradigm
Offspring may use various sensory modalities to learn from the mother, but this has in pigs received relatively little research attention. The objective of this study was to investigate social cues between sow and piglet during a learning scenario related to foraging. We hypothes...
- Health & Medicine
Achieving isoform selectivity within the galectin family remains a central challenge in glycomimetic drug design due to the highly conserved architecture of their carbohydrate recognition domains. Here, we define the structural and thermodynamic basis of recognition of a series o...
- BiologyOpen access
Abstract We present and validate a pioneering ‘IHC/LCM-Seq’ method for transcriptome profiling of spatially defined neuronal cell types detected with immunohistochemistry in sections of formaldehyde-fixed human brains. Application of IHC/LCM-Seq to male human hypothalami enables...
- BiologyOpen access
Immune-mediated inflammatory diseases (IMIDs) arise from interactions among genetic susceptibility, epithelial barrier function, microbiota, diet, and other environmental exposures. Modern diets influence mucosal immunity not only through fibre intake, food processing, and microb...
- Engineering & TechnologyOpen access
Aggregate building indicators can obscure substantial differences in electrical demand and thermal operation among monitored spaces. This case study examined 89 days of one-minute building management system (BMS) and smart-meter records from a multi-zone university building. Rout...
- Society & EconomicsOpen access
Automated OCEL transformation for real-time conformance in complex manufacturing
Abstract Object-Centric Process Mining (OCPM) provides a sophisticated framework for analyzing multi-object interactions in complex manufacturing; however, its practical adoption is limited by the labor-intensive transformation of heterogeneous data into Object-Centric Event Logs...
- Society & EconomicsOpen access
Abstract Iran is currently grappling with critical environmental and economic challenges, including rising CO 2 emissions, frequent blackouts, and ongoing economic stagnation. Despite a growing body of literature on the energy-emissions nexus, much of it has overlooked the integr...
- BiologyOpen access
Ligand-based pharmacophore modeling for the discovery of NaV1.7 inhibitors
Abstract Voltage-gated sodium channel Na V 1.7 is a key mediator of electrical excitability and signal transmission in peripheral nociceptors and has emerged as a highly attractive therapeutic target for the development of novel analgesic agents. However, the development of selec...
- BiologyOpen access
Background: Pseudomonas aeruginosa combines intrinsic resistance, adaptive plasticity, and biofilm formation, making treatment failure common in veterinary and human medicine. We examined whether geraniol and Tris-ethylenediaminetetraacetic acid (Tris-EDTA) modulate marbofloxacin...
- BiologyOpen access
Unsupervised Annotation Transfer in Phase-Contrast Microscopy Using a CycleGAN
Domain shift between microscopy imaging domains poses a significant challenge for deploying deep learning-based cell detection models across different experimental setups. Manual annotation of new microscopy datasets remains resource-intensive and time-consuming. This study prese...
- Materials & EnergyOpen access
Abstract Barite (BaSO₄) is a strategically significant industrial mineral utilized in drilling fluids, high-density construction materials, radiation shielding, and advanced engineered applications. Its increasing relevance to energy industries, import-dependent supply chains, an...
- Health & MedicineOpen access
Abstract Zinc (Zn) and copper (Cu) support epithelial integrity, nutritional immunity, and host–microbiome interactions, yet cervicovaginal trace-metal dynamics across vaginitis phenotypes remain poorly defined. We prospectively quantified cervicovaginal lavage (CVL) Zn and Cu by...