University of Debrecen

Lifestyle-Associated Biomarkers of Cellular and Whole-Organism Aging: A Practical Roadmap for Human Geroscience Trials

Aging is a multidimensional biological process that is not adequately captured by chronological age alone. Geroscience—the study of biological mechanisms that drive age-related functional decline and disease susceptibility—therefore requires biomarker frameworks that can identify...

Treatment restrictions after acute stroke across nine European countries and their association with 90-day mortality: a post hoc analysis of the PRECIOUS randomised controlled trial

Background In patients with acute stroke, early withholding or withdrawal of life-sustaining therapies is associated with an increased risk of death. We used practice variation across nine European countries to assess whether this relation may be causal. Methods We performed a po...

Deciphering Precambrian Litho-structural settings and barite-associated mineralization through integrated hyperspectral and geophysical datasets

Effective lithological mapping and mineral exploration remain challenging in geologically complex and underexplored Precambrian terrains. This is particularly relevant to the Arabian–Nubian Shield (ANS), a Neoproterozoic orogenic belt extending across northeastern Africa and Arab...

Capillary Gel Electrophoresis Separation of dsDNA Molecules Using Tetrahydroxyborate Stabilized Hydroxyethyl Cellulose – Polyvinylpyrrolidone Physical Copolymer

Abstract The advent of nucleic-acid–based therapeutics has revived the need to develop efficient capillary gel electrophoresis methods for their rapid, high-resolution analysis. In this paper, we introduce a dual-network hydrogel-based physical copolymer, utilizing the excellent...

Unveiling Cerebrospinal Fluid Protein Biomarkers in Pediatric Acute Lymphoblastic Leukemia Using a Proximity Extension Assay

Abstract Acute lymphoblastic leukemia (ALL) is a heterogeneous pediatric malignancy where relapse and central nervous system (CNS) involvement remain critical challenges. We combined high-throughput proteomics and machine learning (ML) to identify cerebrospinal fluid (CSF) biomar...

Microsatellite and Mitochondrial DNA Reveal Spatial Genetic Variation and Domestic Cat Admixture in Hungarian European Wildcats

The European wildcat (Felis silvestris) is threatened due to habitat loss and hybridisation with domestic cats (Felis catus), representing a significant conservation challenge in Hungary. We genotyped 118 field-collected cats from seven Hungarian sub-regions and 30 domestic cat r...

Does Obesity Influence the Outcomes of Supine Mini-Percutaneous Nephrolithotomy? A Retrospective Observational Study

Background and Objectives: The objective of this study is to evaluate the impact of obesity on postoperative outcomes following supine mini-percutaneous nephrolithotomy (mini-PCNL). Materials and Methods: This retrospective observational study included 110 consecutive patients wh...

Effects and Types of Future-Orientation on Adolescent Health Behaviour and Wellbeing: A Systematic Review

Abstract Background Health-related behaviours acquired in adolescence significantly shape health outcomes in adulthood. Future Time Perspective (FTP) and Future Orientation (FO) are critical temporal frameworks influencing these developmental trajectories during a period characte...

Transcriptional regulation and function of GPR18 in macrophage subtype specification

Resolution of inflammation is mediated in part by agonists that engage immune cells to dampen inflammatory signaling, promote phagocytic functions, and facilitate tissue repair. G protein–coupled receptor 18 (GPR18) has emerged as an important proresolving receptor that is activa...

Formation of Toxic Products During the Chlorination of Aspartic Acid

Abstract Chlorination is the most widely applied disinfection method in drinking water treatment, but it may lead to the formation of harmful disinfection by-products (DBPs). Amino acids present in natural waters and algal biomass are regarded as important precursors of DBPs. In...

Mitochondrial carrier SLC25A34 links clock, diet, and temperature control of adipocyte lipid cycling

Adipocyte lipid metabolism is coordinated by circadian rhythms, diet, and environmental temperature, but how these diverse signals are molecularly integrated remains unknown. We showed that these cues converge on the orphan mitochondrial transporter SLC25A34 to orchestrate lipid...

Factors influencing global life expectancy across different income levels using Shapley value decomposition

The convergence of life expectancy across nations is a pivotal subject of inquiry in global health economics. Traditional econometric approaches have difficulty precisely allocating the relative contributions of multiple interacting variables, especially in nonlinear or complex m...

Estimating the convex relaxation of the ideal magnetohydrodynamics equations

We investigate the explicit convex relaxation of the ideal magnetohydrodynamics equations. We provide a non-trivial lower estimate on the lamination hull and an upper estimate on the Λ-convex hull, the latter providing inequalities which will be satisfied by weak limits of weak s...

Agricultural Reuse of Phosphogypsum in Contrasting Soils: Wheat Yield, Potentially Toxic Element Uptake, and Soil Microbial Community Responses

Phosphogypsum (PG) is a high-volume industrial by-product that is receiving increasing attention as an alternative soil amendment. This study presents a two-year pot experiment evaluating the effects of PG on spring wheat (Triticum aestivum L.) grown on two contrasting soils: an...

Comparative Evaluation of UAV Multispectral Sensors for Precision Agriculture: Spectral and Structural Consistency in Maize Canopies

Precision agriculture increasingly relies on UAV-based multispectral sensors, but cross-platform data fusion remains limited by differences in spectral response, image geometry, and structural reconstruction accuracy. This challenge is particularly important in dense crop canopie...

Small units in CNS

Abstract Let $$\mathbb{K}$$ K be an algebraic number field of degree $$k$$ k with a canonical number system $$(\alpha, \mathcal{N})$$ ( α , N ) . Denote $$S$$ S a finite set of places of $$ \mathbb{K}$$ K including the archimedean places and such that there is a place $$v\in M_\m...

Selective immunoglobulin A deficiency and coeliac disease: Immune response dynamics

Abstract Objective To analyse the serological immune response in paediatric patients with selective immunoglobulin A deficiency (SIgAD) and coeliac disease (CeD), focusing on immunoglobulin G antibody dynamics after starting the gluten‐free diet (GFD). Methods Data from SIgAD pat...

Assessing the Metric Accuracy of Free iPhone LiDAR Applications for Multiscale 3D Documentation

Abstract The integration of LiDAR sensors into consumer smartphones has opened new possibilities for low-cost 3D documentation, yet the metric accuracy of free iPhone LiDAR applications across different spatial scales and environmental conditions has not been rigorously character...

Phase-space Fisher information along the adiabatic path. Connection to the correlation energy

The thermodynamic view of density functional theory is extended along the adiabatic path. A particular kinetic-energy-density gauge is selected by minimizing the phase-space Fisher information under fixed density and total kinetic energy. Utilizing this choice, a relation between...

Who chooses the nest? An experimental test of nest cover selection

Abstract Nesting site selection has key fitness consequences for both parents and their offspring. Despite previous investigations of the factors influencing the nesting decisions of varied taxa, the relative roles of the sexes in nesting decisions in species with biparental care...