University of Chester

On the value of MRI in early cognitive risk prediction: survival analysis comparing statistical and machine learning models

Abstract Background Early identification of individuals at risk of developing amnestic Mild Cognitive Impairment (aMCI) is essential for timely intervention in Alzheimer’s disease (AD). For such identification, MRI data may be included to capture brain changes and identify clinic...

Incretin-based injectable strategies versus intensified insulin for treatment intensification and simplification in type 2 diabetes: a systematic review and meta-analysis

Abstract Purpose Prandial insulin intensification in Type 2 Diabetes (T2D) improves glycaemia but increases regimen complexity, weight gain, and hypoglycaemia risk. Our aim was to evaluate if Incretin-based injectable strategies offer a lower-burden alternative across intensifica...

Error estimates for stochastic time-fractional Allen–Cahn equations with integrated additive noises: smooth and nonsmooth cases

Abstract In recent work, Al-Maskari and Karaa [2] considered error estimates for a fully discrete scheme to solve a stochastic time-fractional Allen–Cahn equation driven by additive integrated noise, assuming the existence of a solution $$u \in L^{2p} (\Omega ; \dot{H}_{0}^{1} (\...

Strengthening evidence on migrant workers’ health in Nepal

Abstract Thousands of Nepalese labour migrants have died abroad in past decades, and morbidity is also high. The high volume of data collected through pre-departure health screening, unfortunately, remains largely unused. Making better use of health data, including by trusted pub...

Nonlinear Volterra Integral Equation with Solution-Dependent Singular Kernels: Well-Posedness, Regularity, and Numerical Approximation

In this paper, we consider a collocation method for solving a nonlinear Volterra integral equation involving the solution-dependent singular kernel (t−s)−α(u(s))F(s,u(s)), where F(s,u(s))=sσϕ(s,u(s)), 0<σ<1, and ϕ is a suitably defined nonlinear function. We first establish the e...

The set-theoretic Kaufmann–Clote question

Let M be the set theory obtained from ZF by removing the collection scheme, restricting separation to Δ0-formulae and adding an axiom asserting that every set is contained in a transitive set. Let Πn-Collection denote the restriction of the collection scheme to Πn-formulae. We pr...

The invisible pass: asynchronous e-learning and the enforcement of neurotypical identity performance in neurodivergent adults

Purpose Digital learning environments are increasingly framed as flexible and inclusive, yet the identity work required of neurodivergent learners within these spaces remains largely unexamined. This paper argues that asynchronous e-learning platforms, by eliminating interpersona...

Social media utilization in SMEs: a configurational analysis based on institutional theory and UTAUT

Purpose Despite extensive research on social media marketing, limited attention has been paid to how institutional pressures and technological factors jointly shape small and medium-sized enterprises’ (SME) social media marketing use, particularly in developing economies, where t...

Conceptualising family business 5.0 as a socioemotional wealth driven framework for responsible family business transformation

Abstract Purpose This paper introduces the construct of Family Business 5.0 (FB5.0) as a conceptual domain of Industry 5.0 (I5.0), providing a human-centric framework for sustainable digital transformation in family businesses (FBs). It explores how emerging technologies can be h...

Whose Emotional Intelligence Counts? Behaviour, Competence and the Organisational Interpretation of Emotional Intelligence

Emotional Intelligence (EI) has become a defining feature of leadership development, recruitment and performance management. We argue, however, that as EI has become embedded within organisational practice, its assessment has gradually shifted from recognising emotional capabilit...

Inferential learning explains association between self-relevance cues and overlap in chimpanzee visual bodily gesture repertoires

We investigated whether the association of self-relevance cues with overlap in visual bodily gestures is better explained by inferential learning or experience-based reinforcement of gesture–outcome contingencies. Inferential accounts predict that self-relevance cues facilitate c...

Hypertension in Young Adults in Nigeria: A Review of Prevalence and Emerging Trends

Abstract Background Hypertension is increasingly being observed among young adults in low- and medium-income countries, including Nigeria. Although national estimates show a rising burden over the last three decades, the extent to which these trends affect younger populations rem...

Retinoic Acid Receptor γ Is a Ligand-Activated Gatekeeper to Stem Cell Developmental Progression

RARγ is expressed during embryogenesis by stem/primitive progenitor cells, indicating a role in controlling their development. Supporting this view is that a physiological level of 10 nM of the RARγ agonist AGN205327 blocked stem/progenitor cell differentiation during zebrafish e...

Patient involvement with the HCR-20: a qualitative interview study of professionals’ experiences of collaborative risk assessment and management

Purpose The assessment and management of violence risk is integral to a patient’s care pathway in secure mental health care. Risk assessment tools, such as the Historical Clinical Risk-20 (HCR-20), are embedded in practice, framing an individual’s risk and supporting clinical dec...