University of Castilla-La Mancha

Prevalence of neuropsychiatric and seizure disorders in neurofibromatosis type 1: a systematic review and meta-analysis

Neurofibromatosis type 1 (NF1) is associated with intellectual disability (ID), autism spectrum disorder (ASD), attention deficit hyperactivity disorder (ADHD), emotional and seizure disorders. However, published prevalence estimates vary widely. The aim of this meta-analysis was...

Evaluating Firm Quadruple Bottom Line (QBL) Performance: Development and Validation of a Brief Scale

ABSTRACT The quadruple bottom line (QBL) has emerged as a critical framework for assessing corporate performance beyond economic, social, and environmental metrics. Although previous models have proposed additional dimensions such as governance, growing attention is now being dir...

The EU 's Indo‐Pacific Strategy: Perspectives From Australia

ABSTRACT This article examines perceptions in Australia of the European Union's Indo‐Pacific Strategy, drawing on interviews conducted with government officials, experts and civil society actors. The EU is regarded positively as a friend and partner of Australia and equally commi...

Pharmacogenetic, Clinical, Prescribing, and Demographic Predictors of Sertraline Pharmacokinetics

Background: Interindividual variability in sertraline pharmacokinetics remains substantial, but the relative contributions of pharmacogenetic (PGx), demographic, clinical, and prescribing determinants have not been comprehensively evaluated in routine clinical practice. The study...

From Trials to Treatment: Current Evidence Supporting Faricimab Use in nAMD and DME

Neovascular age-related macular degeneration (nAMD) and diabetic macular edema (DME) are leading causes of visual impairment and require long-term intravitreal anti-vascular endothelial growth factor (VEGF) therapy. However, treatment burden and suboptimal real-world outcomes rem...

Acceptance of the possibility of simulated patient death among final-year medical students: a repeated cross-sectional study across eight consecutive cohorts

Simulation scenario design has long been guided by a recommendation that the simulated patient should not be allowed to die, on the grounds that a fatal outcome may impair learning and compromise psychological safety. This "no-death paradigm" rests largely on expert opinion and o...

Longitudinal associations of objectively measured sedentary behaviour and physical activity intensities with urinary incontinence among middle-aged women: a cohort study

Abstract Background Urinary incontinence is a prevalent condition among middle-aged women, yet its relationship with activity behaviours remains underexplored. This study aimed to explore the longitudinal associations between objectively measured sedentary behaviour and physical...

Lifestyle and its relationship with health literacy, sense of coherence and sociodemographic factors in a Spanish primary care population: a multicenter cross-sectional study

Health behaviors are driven by a complex interplay of individual and structural factors. While health literacy and sense of coherence are widely studied as psychosocial enablers of healthy lifestyles, evidence comparing their impact against broader social determinants of health r...

Adherence to the Mediterranean Diet and Academic Performance in University Students: A Systematic Review and Meta-Analysis

Background/Objectives: Adherence to the Mediterranean diet (MedDiet) has been associated with numerous health benefits, yet it is often suboptimal among university students. Its relationship with academic performance (AP), an outcome with potential long-term implications, has not...

High levels of cell-free hemoglobin and iron in cerebral thrombi of pre-Omicron COVID-19 stroke patients: novel drivers of SARS-CoV-2–induced prothrombotic state

The pathophysiological mechanisms underlying the hypercoagulable state and thrombotic events associated with COVID-19 remain incompletely understood. To investigate prothrombotic alterations during SARS-CoV-2 infection, we performed an exploratory and integrated analysis of cereb...

Ethanol steam reforming under engine exhaust-like conditions: energy recovery of reformate and coke-to-power integrated approach

Ethanol steam reforming (ESR) was evaluated as an on-board energy recovery strategy for internal combustion engines under engine exhaust-like conditions using a bench-scale reactor and two catalysts: a commercial Ni/Al₂O₃ catalyst promoted with CaO and K₂O, and a Co catalyst supp...

Tisa-cel and axi-cel CAR structure influences the development of resistance to CD19-CAR-T therapy

CD19-CAR-T cells are a major therapy for relapsed/refractory B-cell malignancies, yet ~50% of patients relapse after infusion. Clinical data suggest that tisa-cel treatment is associated with higher rates of CD19 mutation than axi-cel, though direct comparisons have been lacking....

Rethinking hybristophilia: Media, culture, and the multidimensional construction of attraction to violent offenders

In recent years, hybristophilia has gained increasing visibility within contemporary media and digital ecosystems, particularly in the context of true crime, criminal fandom, and online communities centred on notorious offenders. However, this growing visibility contrasts with a...

Use of the STRYD® Power Meter and Its Metrics in Trained Runners: A Systematic Review

The STRYD® power meter has been used by runners and running coaches in recent years. The data it provides may offer useful information for training monitoring and performance assessment. Accordingly, this systematic review identifies and analyzes the use of the main parameters pr...

Women's Perceptions of Sexual Function During the Postpartum Period: Systematic Review of Qualitative Evidence

INTRODUCTION: Sexuality is a multifaceted aspect of life influenced by several dimensions, including biology, psychology, socioeconomics, and spirituality. Postpartum sexual health remains an understudied and relevant area for women. This systematic review of qualitative studies...

Resilience behaviors as mechanisms for scaling impact in social enterprises

Purpose This study examines how social enterprises build organizational resilience during scaling processes, extending the Nonprofit Resiliency Framework beyond crisis contexts to scaling scenarios. Design/methodology/approach Qualitative research based on 21 in-depth interviews...

Recovery and characterization of a field derived Bagaza virus with broad cellular host range

Abstract Bagaza virus (BAGV) is an emerging orthoflavivirus that primarily infects wild birds, but its ability to infect other hosts remains poorly understood. We isolated infectious BAGV from the brain of a dead red-legged partridge by transfection of extracted viral RNA and eva...

Navigating innovation and risk: evaluating European consumer perceptions of gene editing and pesticide use in watermelon production

Abstract Background Perceived risks associated with food production are a major concern among European consumers and strongly influence debates on sustainable agricultural practices. In particular, the adoption of precision-bred (gene-edited) crops and the use of alternative pest...

Screen Use, Child Development and Family Involvement in Children Aged 2–7 Years: A Systematic Review

INTRODUCTION: This study aimed to explore the effects of screen time on the development of children and the mediating role of families, following the PRISMA method. METHODS: Searches were conducted in Web of Science, Scopus and ERIC databases between 2020 and 2025. Eighteen artic...

Institutional sustainability mediates the effects of university branding on student loyalty

The objective of this study is to analyse the mediating role of perceived institutional sustainability as a mechanism that strengthens the relationships between reputation, brand image and loyalty in higher education institutions. Although the university branding literature has e...