University of Campania "Luigi Vanvitelli"

Association of FOXP3 Gene Polymorphisms with Skin, Vulvar and Ectocervical Squamous Cell Tumors

Background and Objectives: Squamous cell tumors arise from squamous epithelial cells. Polymorphisms in the FOXP3 gene may influence malignancy susceptibility. This study evaluated the potential association of FOXP3 rs3761548 (−3279 A/C) and rs2280883 (IVS9+459 T/C) polymorphisms...

Histatin-Based Metallopeptides Target Secondary Biofilms Derived from Candida albicans Persister Cells in Recurrent Vulvovaginal Candidiasis

Biofilm-associated persister cells contribute to the recurrence and treatment failure of Candida albicans infections. Here, two Histatin 5-derived peptides (P1 and P2) and their silver(I)-coordinated derivatives (M1 and M2) were evaluated against a vaginal C. albicans clinical is...

Weight Regain After Discontinuation of GLP-1 and GIP/GLP-1 Receptor Agonists: A Systematic Review

Background: Weight regain and loss of cardiometabolic benefit commonly follow the withdrawal of glucagon-like peptide-1 receptor agonists (GLP-1RAs) and dual glucose-dependent insulinotropic polypeptide/GLP-1 receptor agonists, yet maintenance strategies are incompletely characte...

Simplification and Derivatization of Quinoline-Containing M41 Lead to the Discovery of NADPH Oxidase Isoform-Selective Inhibitors Effective in Cancer Cells

Abstract NADPH oxidases (NOXs) are attractive but challenging drug targets. Starting from M41 and its analog MC4876, we synthesized quinoline-based derivatives. SAR studies revealed that modifications at the quinoline C2 position and the amine-moiety influenced potency and isofor...

Travel distance to tertiary healthcare reflects disease severity and medication access in Italian systemic sclerosis patients: a geographical study on adult-onset rare diseases from SPRING-SIR registry

Systemic sclerosis (SSc) is a rare, multiorgan disease in adults that requires specialized care. Commuting to tertiary medical centers poses a considerable burden and incurs significant costs, potentially affecting management choices. This study aims to describe the healthcare co...

Abnormal neurovascular coupling in the precuneus–posterior cingulate cortex may bridge simple and complex aura phenomena in the migraine brain

Migraine aura is a heterogeneous phenomenon in which visual symptoms predominate, while a substantial proportion of patients also experience somatosensory and, more rarely, dysphasic or motor manifestations. While neurovascular coupling (NVC) abnormalities within the visual corti...

A Thiophilic Metal-Mediated Cysteine S -Detritylation Strategy: Enhancing Orthogonality in Solid-Phase Peptide Synthesis

Abstract The selective manipulation of cysteine residues in solid-phase peptide synthesis (SPPS), beyond disulfide bridge formation, remains challenging, and an efficient protocol for the selective removal of the widely used trityl (Trt) protecting group under solid-phase conditi...

Antibody-Dependent Cellular Phagocytosis and Cytotoxicity in Patients With LGI1 and CASPR2 Encephalitis

This database includes the raw data linked with the paper “ Antibody-dependent cellular-phagocytosis and -cytotoxicity in patients with LGI1 and CASPR2 encephalitis”. Objective: Antibodies against LGI1 and CASPR2 (LGI1/CASPR2-IgG) associate with forms of autoimmune encephalitis (...

Vitamin D in coronary heart disease: a Mendelian randomization meta-analysis of data stratified by 25(OH)D levels

Maria Fusaro, Pasquale Perrone Filardi, Gianfranco Sinagra, Maria Luisa Brandi, Maurizio Gallieni, Jean-Yves Reginster, Eugene McCloskey, Etienne Cavalier,

The Behavior of the External Limiting Membrane and Ellipsoid Zone in Diabetic Macular Edema: A Population AI-Assisted Optical Coherence Tomography Study

Purpose: To investigate the behavior of the external limiting membrane (ELM) and ellipsoid zone (EZ) in diabetic macular edema (DME) using artificial intelligence (AI)-based optical coherence tomography (OCT) quantification. Methods: This was a cross-sectional study. OCT scans of...

Central neurocytomas: Decision-making process of postoperative treatment. Lesson learned

Central neurocytoma is a rare intraventricular tumor with favorable prognosis following gross total resection (GTR). However, the role of Ki67-MIB1 values in the postoperative decision making-process of treatment, as well as the indication for adjuvant radiotherapy, remain debate...

Evidence-based evaluation of berberine in neurodegenerative diseases: targeting multiple signaling pathways and modulating neuroinflammation, oxidative stress, and apoptosis

Neurodegenerative diseases (NDs), such as Alzheimer’s disease (AD) and Parkinson’s disease (PD), are characterized by progressive neuronal loss, oxidative stress, mitochondrial dysfunction, and neuroinflammation. Novel neuroprotective drugs are urgently required since existing tr...

Radiomics-based prediction of pituitary adenoma consistency: a systematic review and meta-analysis

Abstract Purpose Pituitary adenoma consistency significantly influences surgical strategy and outcomes, yet it cannot be reliably predicted using conventional imaging. By converting images into quantitative data, radiomics can identify imaging patterns that may not be distinguish...

Stripping‐based approach for the recovery of volatile fatty acids from anaerobic digestion digestate: preliminary experimental investigations and modelling

Abstract BACKGROUND Volatile fatty acids (VFAs) are widely used across industries: as intermediates in chemical production (e.g . , solvents and polymers), in pharmaceuticals and cosmetics, and as preservatives and health‐promoting additives in food and animal feed. Emerging appl...

Predicting the risk of dehydration and readmission among rectal cancer patients with ileostomy: a multicenter observational study

Abstract Dehydration is a frequent complication among rectal cancer patients after ileostomy, often resulting in hospital readmission. The Dehydration Readmission after Ileostomy Prediction (DRIP) score was used to identify patients at risk of dehydration-related readmission. The...

Dengue virus serotype classification from complete genomes using a Transformer with chunk-based sequence modeling and explainability analysis

Artificial intelligence is increasingly used for genomic surveillance of infectious diseases, but predictive models must be evaluated under realistic generalization settings and interpreted cautiously. We present XAI-DENFormer, an explainability-oriented framework for dengue viru...

Numerical analysis of suction caisson foundations under cyclic lateral loading in sand

A parametric study on the monotonic and long-term cyclic response of suction caisson foundations for offshore wind turbines is presented. Three-dimensional finite element analyses of a caisson embedded in sand were performed in Abaqus/Standard using a semi-explicit calculation st...

Salivary hormones and adipokines are associated with glycemic control and early renal and cardiometabolic markers in children and young adults with type 1 diabetes

Abstract Purpose Type 1 diabetes (T1D) is recognized as a complex metabolic condition associated with hormonal dysregulation and early complications. This study aimed to evaluate salivary metabolic hormones and adipokines in children and young adults with T1D, and to assess their...

A New Sustainable Approach to Antibiotic Resistance: Development of bis‐Quaternary Ammonium Salts From 2,4,6‐Trichloro‐1,3,5‐Triazine

The development of highly effective antibiotics and antimicrobials over the centuries has greatly improved human life. However, the irresponsible use of these substances and their release into the environment have led to the emergence of resistant microorganisms. Quaternary ammon...

The Costs of Parkinson's Disease in Europe: Results of the Costs of Illness in Neurology Initiative

Abstract Background Parkinson's disease (PD) is the second most common neurodegenerative disease. It imposes substantial and growing burden on patients, families, and caregivers and reduces quality of life. The disability and care needs associated with PD carry economic ramificat...