University of California, Irvine Medical Center

Histological and Biomechanical Considerations of Donor Costal Cartilage Allografts for Total Ear Reconstruction

ObjectiveDonor costal cartilage (DCC) allografts for microtia reconstruction have shown promising clinical results, but characterization of the allografts' intrinsic properties has yet to be performed.DesignHistologically, DCC allografts were compared to autologous costal cartila...

Evolving Surgical Paradigms in Early-Stage Cervical Cancer: De-escalation, Minimally Invasive Approaches, and Lymph Node Assessment

Abstract Purpose of Review This review examines the evolving surgical paradigms in early-stage cervical cancer, with an emphasis on the deescalation of radical surgery, the ongoing debate surrounding minimally invasive approaches, and the advancements in lymph node assessment. Re...

From Ionic Agitation to Precision Neuroablation: A Bioengineering Perspective on the Mechanisms, Modalities, and Clinical Applications of Radiofrequency Technology in Pain Management

Radiofrequency ablation (RFA) is a foundational interventional technology in pain management. Despite the diversity of available systems, conventional thermal, internally cooled, bipolar, and pulsed radiofrequency (PRF) all share one biophysical mechanism: high-frequency alternat...

Rethinking Restrictive Diets in IBD: Toward an Inclusion-Focused Nutritional Paradigm

Abstract Purpose of Review Patient-initiated elimination diets are widely adopted by those with inflammatory bowel disease (IBD), yet the evidence supporting their long-term use remains limited and their risks are increasingly recognized. Some common elimination diets utilized by...

High-grade astrocytoma with piloid features: a clinical and genomic analysis of prognostic factors using a large cohort

BACKGROUND: High-grade astrocytoma with piloid features (HGAP) is a recently defined tumor type that is not well-understood. Prognostic factors of clinical outcomes are not well-established. METHODS: Methylation profiling was performed on tumor samples, many at the National Cance...

Clinical trial barriers in neurostimulation for pediatric drug‐resistant epilepsy

Abstract Objective The NeuroPace responsive neurostimulation (RNS) System effectively treats focal drug‐resistant epilepsy (DRE) in adults but lacks pediatric regulatory approval. Despite effective off‐label pediatric use, systemic device‐trial challenges have impeded label expan...

Radiology considerations for the PREMIUM study: a multicenter randomized controlled trial of abbreviated MRI versus ultrasound for liver cancer screening in cirrhosis

Abstract This paper describes the rationale and radiology considerations in the implementation of the Preventing Liver Cancer Mortality through Imaging with Ultrasound versus MRI (PREMIUM) study. PREMIUM is a multicenter, randomized controlled trial sponsored by the Department of...

Comparative Pharmacovigilance Analysis of Safety Signals Among Advanced Prostate Cancer Therapies Using FAERS (FDA Adverse Event Reporting System)

Therapeutic options for advanced prostate cancer have expanded in recent years, incorporating multiple-system treatment approaches with differing mechanisms of action. However, comparative real-world safety data following drug approval remain limited. As such, the aim of this stu...

The establishment of prostate-specific, SKP2 humanized mice by CRISPR knock-in method reveals neoplastic initiation and microenvironmental reprogramming

Abstract A recent study has shown that SKP2 inactivation can prevent cancer initiation by extension of total cell cycle duration without perturbing normal division, which suggests a new strategy for cancer prevention. However, direct in vivo evidence for human SKP2 on cancer init...