University of Cagliari

Oxygen deficiency and valency reconstruction in multiferroic V-doped HfO 2

The interplay of oxygen deficiency and vanadium multiple valency in the candidate multiferroic V-doped P c a 2 1 hafnia HfO 2 is studied by first-principles calculations. Low-lying V majority gap states accept electrons from oxygen-vacancy donors, reducing their formation energy,...

Assessing Behavioral and Environmental Facets of Obesity Unobtrusively Utilizing Digital Tools: Introducing the BETTER4U Indicators

ABSTRACT Understanding obesity involves evaluating numerous contributing factors. Collecting the necessary data for this can impose a significant burden on both research participants during clinical studies and real‐life deployments of digital tools aiding obesity management. The...

Emerging therapeutic strategies and clinical trials in severe asthma management: current evidence and future directions

Introduction Biologic therapies have transformed the management of severe asthma, particularly in type 2-high disease, but important unmet needs remain. Incomplete responses, uncertainty in treatment positioning, and the lack of effective options for non-type 2 or mixed inflammat...

Knowledge, attitudes, and practices about severe mental illness and willingness-to-pay for a new integrated care model across 6 European countries: a study protocol

Background People with Severe Mental Illness (SMI) experience a 15–20-year shorter life expectancy than the general population, with increased premature deaths from somatic illnesses, and twice to more than four times the general population’s all-cause mortality risk. Integrated...

Fructose Promotes Oxidative Stress, Sphingolipid Remodelling and Transient Intestinal Barrier Dysfunction in Differentiated Caco-2 Cells

Background/Objectives: High dietary fructose consumption has been linked to impaired intestinal barrier function and several metabolic disorders. Although oxidative stress has been proposed as a mediator of fructose-related epithelial injury, the involvement of tight-junction (TJ...

Sexually Transmitted Infections in the Third Age: Rising Risk Among over 65-Year-Old Persons in Southern Sardinia

Background/Objectives: Population ageing and the persistence of sexual activity in later life are reshaping sexual health needs. Older adults are often overlooked in STI surveillance and prevention, and data on infections among those aged ≥65 years remain limited. This study desc...

From Auditing to (Re)designing: Recommender Systems for User Empowerment in Very Large Online Platforms Under the Digital Services Act

The governance of recommender systems (RSs) in very large online platforms (VLOPs) is expected to change significantly under the Digital Services Act (DSA), which imposes specific obligations on algorithmic transparency and user control. However, beyond legal compliance, a critic...

Informed Consent for the Publication of Case Reports of Deceased Subjects in Medicolegal Journals: A Comparative Review of Editorial Policies and a Proposal

Introduction Case reports and case series are central to forensic pathology, yet they almost invariably concern a deceased subject and often contain potentially identifying material. International publication ethics standards on consent (ICMJE, COPE) were designed for the living...

Maternal SARS-CoV-2 exposure and neonatal metabolic maturation during the first month of life: a longitudinal urinary metabolomics study

Abstract The first month of life is characterized by rapid metabolic adaptation as neonates transition from intrauterine to extrauterine life. Whether maternal SARS-CoV-2 infection influences these developmental trajectories remains largely unexplored. In this longitudinal study,...

N-terminal proVGF modifications related to Amyotrophic Lateral Sclerosis

Objective: Amyotrophic Lateral Sclerosis (ALS) is a progressive neurodegenerative disorder characterized by motor dysfunction, for which effective therapies and early diagnostic biomarkers remain limited. This study comprehensively investigated ALS-associated alterations in the N...

Using multi-trait polygenic scores to predict lithium responsiveness in patients with bipolar disorder

Background The predictive power of polygenic scores (PGSs) for lithium treatment response in bipolar disorder remains limited. Aims To enhance the prediction of lithium responsiveness by developing a multi-trait PGS (mt-PGS) combining genetic information from multiple phenotypes...

Tracing Colonial Continuities: Internal Colonialism and Energy Transition in Sardinia

ABSTRACT Internal colonialism provides historical and structural conditions making current forms of energy extractivism possible. Processes through which earlier internal colonisation operated—territorial dispossession, racialised hierarchies, forced modernisation and the constru...

Article 265 TFEU and the Gaza inertia: asking too much from the general court?

Abstract Article 265 TFEU establishes a judicial mechanism to challenge the failure of the institutions of the European Union (EU) to act, yet, its practical relevance has long been constrained by restrictive admissibility requirements and judicial deference to institutional disc...

Post-Marketing Reporting Patterns of Ceftazidime–Avibactam and Ceftolozane–Tazobactam: Analysis of Adverse Event Reports from EudraVigilance

Background/Objectives: Ceftazidime/avibactam (CA) and ceftolozane/tazobactam (CT) are WHO Reserve-group antibiotics increasingly used for multidrug-resistant Gram-negative infections. Comparative post-marketing pharmacovigilance data remain limited. Methods: A retrospective pharm...

Mapping Functional Transitions across Protein Homologues from a Single Simulation: Application of gEDES-HM to Adenylate Kinases

Abstract Proteins fluctuate across different conformational states, which constitute a dynamic ensemble that regulates their interaction networks and functions. Predicting the conformational landscape remains a computational challenge, and even more difficult is capturing the lin...

Effective Young’s modulus of a unidirectional fiber reinforced composite: a mean Green operator interpretation

Abstract Experimental measurements of the effective Young’s modulus of an unidirectional composite obtained by embedding 3D-printed PLA–CF fibers in a cold-curing polyurethane elastomeric matrix are presented. Specimens with a controlled number of aligned fibers were tested in un...

Underrated deep-water scleractinian species: an ecological study along the Italian coasts (Mediterranean Sea)

Abstract Scleractinians are key components of Mediterranean mesophotic and bathyal benthic ecosystems, comprising 30 species known to occur below 40 m. A large ROV dataset, including 625 dives, each corresponding to a distinct geographical site, conducted between 40 and 1825 m ac...

Horizon Scanning of Multiple Sclerosis Expenditure in Italy (2025–2029): Updated Insights from the Oracle Model

Multiple sclerosis (MS) is a chronic and progressively disabling neurological disease associated with a substantial clinical and socioeconomic burden. The introduction of an increasing number of new innovative therapies has further intensified concerns regarding the long-term sus...

Clinical Outcomes of Surgical–Orthodontic Management of Impacted Mandibular Canines: A Systematic Review

Background: Impaction of mandibular canines is an uncommon clinical condition, and transmigration represents a severe positional variant within this spectrum. In contrast to maxillary canine impaction, the management of impacted mandibular canines remains less standardized and la...

Rt-PCR detection of West Nile virus in rhino-pharyngeal swabs in patients with neuroinvasive WNV: a preliminary experience

Abstract West Nile virus (WNV) diagnosis relies on serology and/or RNA detection in serum or cerebrospinal fluid (CSF). However, lumbar puncture may be contraindicated in some patients, and serological diagnosis can be limited by impaired antibody responses or persistent IgM posi...