University of Brescia

Bearing behavior of additively manufactured Onyx–Kevlar composites: effect of fiber content and mixed distribution

Abstract This study investigates the pin-bearing behaviour of additively manufactured Onyx–Kevlar composites, focusing on the interplay between fiber content and layer-wise distribution. Specimens were fabricated via Continuous Filament Fabrication with longitudinal Kevlar covera...

A novel network-level integrated crash frequency, exposure and severity approach to assessing and mitigating pedestrian crash risk

One of the main challenges in urban mobility is improving pedestrian safety. Despite recent reductions in road crashes and fatalities, current progress remains insufficient to achieve international road safety targets. Existing studies typically examine crash frequency or severit...

Low-Molecular-Weight Heparin Versus Unfractionated Heparin for Venous Thromboembolism Prophylaxis in Adult Traumatic Brain Injury: A Systematic Review and Meta-Analysis

BACKGROUND AND OBJECTIVES: Traumatic brain injury (TBI) is associated with a high risk of venous thromboembolism (VTE), yet the optimal strategy for thromboprophylaxis remains uncertain. Low-molecular-weight heparin (LMWH) and unfractionated heparin (UFH) are commonly used agents...

Characterizing Pyramidal Hadamard Designs With the Largest Number of Fixed Points

ABSTRACT A symmetric ‐design is said to be ‐pyramidal, with , under the action of a group if acts as an automorphism group fixing points and acting sharply transitively on the remaining ones. We show that, necessarily, . In particular, for a Hadamard design with parameters , for...

Rehabilitation and the post-intensive care syndrome across the recovery continuum: a narrative review

Purpose Improved survival from critical illness has produced a growing population of intensive care unit (ICU) survivors with new or worsened physical, cognitive, and mental-health impairment, defined as post-intensive care syndrome (PICS), and frequent distress among families/ca...

An Updated Evidence Assessment of the Genetic Causes of Dilated Cardiomyopathy

BACKGROUND: Evidence of the diverse genetic architecture of dilated cardiomyopathy (DCM) continues to emerge and requires reassessment of the clinical relevance of implicated disease genes. Building on the 2019-2020 Clinical Genome Resource evaluation, the DCM gene curation exper...

Circuits that guarantee iron homeostasis: from cellular sensing to systemic control

Abstract Iron is an essential yet potentially toxic element whose redox properties support diverse cellular processes, including oxygen transport, energy metabolism, DNA synthesis, and epigenetic regulation. To maintain iron availability while limiting its toxicity, organisms hav...

Assistive technologies (lumbar supports and other devices) for treating chronic low back pain

RATIONALE: Low back pain (LBP) is a major global health problem. It is the most common cause of activity limitation amongst individuals younger than 45 years, and one of the most frequent reasons for visits to a doctor. The 2019 Global Burden of Disease study named LBP as the lea...

Development of an inactivated, oral immunogenic product against post-weaning colibacillosis caused by enterotoxigenic Escherichia coli in piglets

Abstract Background Post-weaning diarrhea (PWD) caused by enterotoxigenic Escherichia coli (ETEC) expressing F4 and F18 fimbriae remains a major challenge in pig production, contributing to economic losses and increased antimicrobial use. This study aimed to preliminary evaluate...

Cemiplimab in cutaneous squamous cell carcinoma: a longer follow‐up study focusing on the late toxicities

Summary Background and Objectives Cemiplimab was the first systemic therapy approved for advanced cutaneous squamous cell carcinoma (cSCC). Patients and Methods We report findings from the Italian early access program cohort, comprising 134 patients treated with cemiplimab, with...

Toward harmonized reporting of Alzheimer’s disease biomarkers in clinical practice

Abstract Cerebrospinal fluid biomarkers, and more recently blood-based biomarkers, are playing a pivotal role in reshaping the clinical management of neurodegenerative diseases, supporting early detection, biological diagnosis, patient stratification, prognostic assessment, thera...

Screening of sarcopenia in long-term care facilities using wireless surface electromyography and deep transfer learning: a proof-of-concept study

Abstract Background Sarcopenia is prevalent in long-term care facilities (LTCFs) and is associated with falls, functional decline, and mortality. Aims This proof-of-concept study, within the I-COUNT pilot randomized controlled trial, evaluated the feasibility and diagnostic perfo...

Autochthonous chikungunya virus outbreak in Verona province, Italy, 2025

Abstract Background Chikungunya virus (CHIKV), primarily transmitted by Aedes mosquitoes, has increasingly caused autochthonous outbreaks in temperate regions, including Italy. In 2025, a local CHIKV outbreak occurred in Verona province, Veneto Region. We report the findings of i...

A nicotinic-dopaminergic hybrid probe enhances D2-like autoreceptor-mediated inhibition of dopamine release

β2-containing nicotinic acetylcholine receptors (nAChRs) and dopamine D 2 receptors (D 2 Rs) cooperate to shape striatal dopamine (DA) output, yet the mechanisms by which nicotinic-dopaminergic crosstalk influences D 2 -like autoreceptor-mediated inhibition of DA release remain u...

Cancer in systemic sclerosis: clinical associations and prognostic impact from the EUSTAR registry

BACKGROUND: Cancer represents a major cause of mortality in systemic sclerosis (SSc). Established risk factors are limited to specific subsets, particularly early diffuse anti-RNA polymerase III (POLR3)-positive disease, needing further exploration. METHODS: We performed a nested...

Humidity-Enhanced Effects of Sputtered Au Nanoparticles on the Ethanol Sensing Performance of Thermally Evaporated ZnO Nanowires

Abstract Mitigating the adverse effects of humidity on the sensing performance of one-dimensional (1D) metal oxide semiconductors has been a key challenge in gas sensor development. This study investigated the humidity-enhanced effect of gold (Au) nanoparticles on the ethanol res...

Could foods from the Mediterranean diet act as a DNA-protective tool against the mutagenic and genotoxic effects of urban fine air particulate matter (PM0.5)? An exploratory investigation on bacteria and human cell lines

Fine particulate matter (PM 0.5 ) is an emerging public health concern due to its ability to penetrate deeply into tissues and induce oxidative stress–mediated damage, contributing to the development of chronic diseases. Despite increasing exposure in urban environments, its biol...

Data-Driven Fatigue Trajectories in Multiple Sclerosis and Their Predictors

Fatigue is one of the most disabling symptoms of multiple sclerosis (MS), yet its longitudinal trajectories and determinants remain poorly characterized. We aimed to identify trajectories of cognitive and physical fatigue in relapsing-remitting MS (RRMS) and to determine baseline...

Functional Activity of TDP-43: A Direct Biomarker for ALS

TDP-43 dysfunction is a defining feature of amyotrophic lateral sclerosis (ALS), yet no biofluid biomarker directly measures its functional activity. We developed a serum-based homogeneous time-resolved FRET (hTR-FRET) assay that quantifies TDP-43 RNA binding activity using synth...

From data to decisions: how neural network input structures propagate to air quality policies

In air-quality planning, Artificial Neural Networks (ANNs) have emerged as surrogate models capable of capturing complex nonlinear relationships between emissions and pollutant concentrations with reduced computational time required by chemical and transport models. However, the...