University of Bergen

Mountain glacier evolution since the last interglacial

Abstract. Mountain glacier evolution since the last interglacial remains poorly constrained, with limited spatial and temporal coverage. Conventional modelling approaches typically target major climatic events, operate at coarse spatial resolution over limited spatial domains, or...

Major adverse cardiac events and mortality associated with ADHD and its treatment in adults with type 2 diabetes: a multi-national cohort study

Abstract Background Attention-deficit/hyperactivity disorder (ADHD) has been linked to elevated risk of type 2 diabetes (T2D). However, the impact of ADHD and ADHD medication use on prognosis and health outcomes in T2D remains unclear. This study investigates the associations of...

Molecular Determinants of Ligand Selectivity in Diverse Ionotropic Glutamate Receptors

Abstract Ionotropic glutamate receptors (iGluRs) mediate rapid signals between neurons by binding extracellular neurotransmitters and conducting ionic current across the cell membrane. Animal iGluRs can be divided into clades of phylogenetically related receptors, only some of wh...

The Pretherapy Endothelial Activation and Stress Index (EASIX) in Patients with Newly Diagnosed Acute Myeloid Leukemia: A Pilot Study

Background/Objectives: The endothelial activation and stress index (EASIX; serum creatinine times lactate dehydrogenase/peripheral blood platelet count) seems to reflect endothelial cell activation/dysfunction. Furthermore, endothelial cells support acute myeloid leukemia (AML) c...

From Fear to Function: How Physiotherapists Navigate Psychological Challenges in Patients Undergoing Rehabilitation After ACL Reconstruction

Background: Psychological readiness plays a critical role in return to sport (RTS) outcomes after anterior cruciate ligament reconstruction (ACLR), yet physiotherapists (PTs) often feel unprepared to support this aspect of recovery. Although clinical guidelines advocate for psych...

Spatiotemporal expression dynamics of CD73 , CD90 , and CD105 based on scRNA ‐seq and immunofluorescence analysis of dental pulp toward establishing a triple‐positive population

Abstract Dental pulp stem cells (DPSCs), a subset of mesenchymal stem/progenitor cells, exhibit remarkable self‐renewal and multipotent differentiation capacity, making them promising candidates for regenerative applications. While their in vitro characteristics have been extensi...

Measurements of the production of W$$^{\pm }$$ and Z$$^0$$ bosons in pp collisions at $$\sqrt{s} = 13$$ TeV

Abstract Measurements of the production of the W $$^{\pm }$$ ± and Z $$^0$$ 0 bosons at midrapidity in pp collisions at $$\sqrt{s} = 13$$ s = 13 TeV with ALICE at the Large Hadron Collider (LHC) are presented. The W $$^{\pm }$$ ± and Z $$^0$$ 0 bosons are detected via their (di)e...

Seasonal influences on DNA methylation at birth or at sampling time and their interaction with psychosis risk

Abstract Background Season at birth has been associated with increased risk for psychotic disorders. Epigenetic markers, which can be influenced by environmental exposures, may help to understand the mechanisms of seasonal effects. Aims To investigate two types of seasonal influe...

AI-Assisted rational enzyme engineering: advancing biocatalysis for industrial applications

The emergence of artificial intelligence (AI) has initiated a paradigm shift in enzyme engineering. While traditional methods like directed evolution and rational design are proven, they often suffer from limited predictive power, scalability, and efficiency. The integration of A...

Consistent drivers of coastal biodiversity across the tree of life

Coastal ecosystems are threatened by global change but remain understudied despite their importance for biodiversity and human society. For instance, most coastal studies and monitoring programs focus on a few groups of organisms owing to methodological limitations. However, high...

Lifetime substance use disorder and suicidal behaviour: a population-based familial co-aggregation register study

Abstract Substance use disorders (SUD) are associated with suicidal behaviour, but less is known regarding the extent to which familial factors influence these associations across different types of SUD. We performed a national register study including 4,209,615 individuals born...

Settlement Dynamics and Coastal Change in the Arabian Gulf Neolithic: Wādī aḍ‐Ḍubayʿān (Qatar)

ABSTRACT This paper presents the results of archaeological investigations (2009–2014) at Wādī aḍ‐Ḍubayʿān (QNHER 141), a stratified littoral Neolithic site on the northwestern coast of Qatar. The site documents occupation from the late sixth to the late fourth millennium BCE , co...

Combined effects of long‑term air pollution exposures on adult active asthma: a quantile g-computation analysis

Abstract Background Air pollution is a well‑established risk factor for the development of asthma, yet most studies examine pollutants individually, failing to capture the health effects of real‑world pollutant mixtures. Assessing long-term multipollutant exposure is essential fo...

From local hubs to regional impact: harnessing the social and solidarity economy in small-scale fisheries

Abstract The global 2030 Agenda for Sustainable Development calls for more equitable and sustainable pathways by integrating traditional communities into development efforts. Despite these ambitions, challenges persist, as many initiatives, including Social and Solidarity Economy...

65. HIGHER POLY-METHYLATION SCORE FOR SCHIZOPHRENIA IS ASSOCIATED WITH GREATER NEGATIVE SYMPTOM SEVERITY AT 10-YEAR FOLLOW-UP

Background Negative symptoms are among the most disabling features of psychotic disorders and frequently persist over time. Baseline clinical measures (e.g. symptom severity at illness onset) explain only part of the variability in long-term outcomes, highlighting the need for im...

Partial differential equations in the age of machine learning: a critical synthesis of classical, machine learning, and hybrid methods

Abstract Partial differential equations (PDEs) govern physical phenomena across the full range of scientific scales, yet their computational solution remains one of the defining challenges of modern science. This critical review examines two mature but epistemologically distinct...

Breaking Symmetry: A New Directionality Criterion for Regularity Theories of Causation

Abstract It is one of the most frequent criticisms of regularity theories of causation that they cannot distinguish between causes and effects based on Boolean determination relations of sufficiency and necessity alone—jeopardizing their goal of reducing causation to Boolean dete...

Filling the gaps in high-priority reference materials for implementing metrological traceability in laboratory medicine

Abstract The global harmonization of measurements in laboratory medicine is facilitated by the development and implementation of reference measurement systems, including suitable certified reference materials (CRMs). There are, however, a relatively small number of CRM producers...

DWI-FLAIR mismatch versus perfusion-based selection for extended window thrombolysis in acute ischemic stroke: a meta-analysis of randomized controlled trials

To compare efficacy and safety outcomes of DWI–FLAIR mismatch versus CT/MR perfusion-based selection for intravenous thrombolysis (IVT) in extended-window acute ischemic stroke (AIS), we performed a systematic review and meta-analysis of randomized controlled trials enrolling adu...

Generational changes in lung function in adults from several world regions: results from the Burden of Obstructive Lung Disease study

This study estimated birth cohort effects on lung function using BOLD (Burden of Obstructive Lung Disease) data from 28 569 adults born between 1902 and 1976 across 41 sites in 34 countries. Forced vital capacity (FVC), forced expiratory volume in 1 s (FEV 1 ) and the FEV 1 /FVC...