University of Augsburg

Microbiome-host communication via vaccenic acid modulates LRH-1/NR5A2 activity and ameliorates metabolic liver disease

Abstract Interactions between microbiota and the host can profoundly affect human health. In particular, microbiota-derived metabolites influence liver physiology and contribute to the development of metabolic diseases, yet the molecular mechanisms underlying microbiome-host comm...

Effects of Resistance Training on Muscle Hypertrophy in Children and Adolescents: A Systematic Review and Meta-Analysis

Abstract Background Resistance training is considered safe and beneficial for young individuals, yet the extent to which it results in morphological adaptations before, during and after puberty remains unclear. Objective The aim of this review was to quantify the effects of resis...

Broadband absorption of ocean wave energy using a graded array of heaving buoys in three dimensions

The generation of renewable power from ocean waves at a commercial scale requires arrays of wave energy converters (WECs) to be designed for efficient power capture over broad frequency bands and a wide range of incident wave directions. Here, array designs are developed in a thr...

Cardiovascular Effects of Chronic GIPR and GLP-1R Agonism in Lean and Diet-Induced Obese Mice: Sex Differences and Dose-Dependent Remodeling

Glucose‑dependent insulinotropic polypeptide (GIP) and glucagon‑like peptide‑1 (GLP‑1) regulate metabolism and are increasingly targeted in therapies for type 2 diabetes and obesity. Although GLP‑1 receptor agonists confer cardiovascular benefits, the cardiovascular effects of GI...

Urinary metabolomics data and cognitive performance in an adult population

Abstract With an ageing population, the social and economic burden of cognitive decline is increasing. Urinary metabolomics may offer a promising approach for identifying metabolic markers for early cognitive impairment and gaining insights into underlying biological mechanisms....

Divergent c-MYC Expression Patterns in NET and NEC: Insights from a Multicentre Cohort of 1380 Neuroendocrine Neoplasms

Abstract Neuroendocrine neoplasms (NEN) comprise well-differentiated neuroendocrine tumours (NET) and neuroendocrine carcinomas (NEC), whose distinction is clinically critical. Although c-MYC alterations have been implicated in NEC pathogenesis, c-MYC expression across NEC subtyp...

Association between body mass index and influenza antibody titer and immune cell count after influenza vaccination: an exploratory study

Abstract Background Obesity is associated with altered immune function and may therefore influence the response to influenza vaccination. So, the objective was to investigate whether body mass index (BMI) affected influenza-specific antibody titers and immune cell counts after va...

Growing Up With Social Robots: Scientific, Ethical, and Theological Anthropological Perspectives on Social Robots, AI Companions, and Child and Adolescent Development

We discuss the increasing presence of social robots (SRs) and artificial intelligence (AI) companions in the contemporary ecology of youth development and the role of parasocial relationships created by youth with these technical artifacts, emphasizing the links between parasocia...

Sexual Health in Psychiatry: Bridging the Communication Gap and Training Needs between Patients and Clinicians – A Cross-Sectional Exploratory Pilot Study

Sexual health is integral to mental well-being, yet it remains under-addressed in psychiatric care. Mental disorders and psychotropic medications can cause sexual dysfunctions. Despite its clinical relevance, sexual health is often not routinely assessed or discussed in psychiatr...

Automated segmentation and length measurement of metacarpal and phalangeal bones for hand radiograph evaluation

Abstract Evaluating hand and wrist radiographs is essential in pediatric endocrinology and clinical genetics, particularly for the assessment of suspected skeletal anomalies. In this study, we present Auto-Bone-Caliper, an automated system for the segmentation and length measurem...

Change in COVID-19 outcomes in lymphoma patients across pandemic waves: results of the COVID-19-lymphoma registry of the Bavarian Cancer Research Center (BZKF) 2020–2022

Abstract Patients with malignant lymphomas are at increased risk for severe COVID-19. In the general population, outcomes of COVID-19 have improved dramatically over time due to increasing immunity through vaccination or infection and due to improved clinical care. It is unclear...

Volumetric reference data of the orbit: a deep learning MRI analysis in the German national cohort

Abstract Manual segmentation of orbital magnetic resonance imaging (MRI) is labor-intensive, hindering large-scale morphometric studies. To overcome this, we developed a fully automated deep learning pipeline to segment orbital MRIs and establish age- and sex-stratified normative...

Compound patterns and environmental drivers of typhoon disaster chains in southeast coastal China: a multiscale framework

Typhoons frequently trigger interacting hazards, including river flooding, urban waterlogging, landslides, and storm surge, but disaster records compiled at the event or administrative-unit level limit systematic analysis of their spatial co-occurrence and environmental different...

Neural network–augmented Pfaffian wave-functions for scalable simulations of interacting fermions

Developing accurate numerical methods for strongly interacting fermions is crucial for improving our understanding of various quantum many-body phenomena, especially unconventional superconductivity. Recently, neural quantum states have emerged as a promising approach for studyin...

Dynamic Demand Management for Parcel Lockers

In pursuit of a more environmentally sustainable and cost-efficient last mile, parcel lockers have gained a firm foothold in the parcel delivery landscape. To fully exploit their potential and ensure customer satisfaction, successful management of the locker’s limited capacity is...

Spatiotemporal Dynamics and Multi-Scale Diagnosis of Urban Resilience to Typhoon Disaster Chains in Fujian, China

Abstract Coastal cities in southeastern China face increasing threats from typhoon-induced compound disasters (for example, torrential rainfall, urban waterlogging, and storm surges) that can cascade into interconnected disaster chains under climate change and rapid urbanization....

Surgical anatomy, biomechanics and clinical outcomes of latissimus dorsi transfer for irreparable rotator cuff tears: a review

BACKGROUND: Latissimus dorsi transfer is a well-established joint-preserving option for irreparable rotator cuff tears in young, active patients without glenohumeral arthritis. Originally described by Gerber in 1988 for posterosuperior tears, indications now also include anterosu...

Correlation of [ 68 Ga]Ga-RAYZ-8009 PET/CT Uptake with Immunohistochemical Glypican-3 Expression in Hepatocellular Carcinoma: A Proof-of-Target Study

Glypican-3, a cell-surface proteoglycan, is overexpressed in most hepatocellular carcinomas (HCCs). Recently, the glypican-3–targeted PET tracer [68Ga]Ga-RAYZ-8009 was shown to enable noninvasive detection of HCC. This retrospective analysis evaluates the correlation between tumo...

Compression of Polyconvex Envelopes of Isotropic Functions via Monotonic Input Convex Neural Networks

ABSTRACT This work presents a novel neural‐network compression approach for polyconvex envelopes of isotropic functions. The approach relies on a classical sufficient criterion for polyconvexity and is particularly suited for the representation of determinant‐constrained energy d...

Modeling of flopping-mode spin qubits: Beyond the two-site model

We present a flexible modeling framework for flopping-mode spin qubits that captures the spatial structure of the double-well confinement and magnetic-field-gradient profile going beyond conventional low-energy descriptions. By using this approach, we simulate electric dipole spi...