University Medical Center

Hemocytometric Parameters Associated with Bacterial and Viral Etiology in COPD Exacerbations: An Exploratory Analysis

Exacerbations of Chronic Obstructive Pulmonary Disease (ECOPD) are often triggered by bacterial and viral infections, yet current diagnostic methods are time-consuming and biomarkers (e.g. C-reactive protein (CRP)) show limited accuracy in differentiating between these triggers....

Immunohistochemistry for c-MET, HLA class II, and CD68 does not show prognostic value in early-stage classic Hodgkin lymphoma patients in the EORTC-GELA H9 intergroup randomised trial

Background In classic Hodgkin lymphoma (cHL), identifying high-risk patients is crucial for tailored treatment. Clinical risk factors are useful, but there is room for improvement. Although many diagnostic tissue-based biomarkers have been described to correlate with prognosis, n...

Sport, exercise, and physical activity in children with cardiovascular disease. A Clinical Consensus Statement of the European Association of Preventive Cardiology (EAPC) of the ESC, the Association of Cardiovascular Nursing & Allied Professions (ACNAP) of the ESC, and the Association for European Paediatric and Congenital Cardiology (AEPC)

Regular physical activity offers numerous benefits to children's health and well-being and is essential for reducing cardiovascular risk in children with cardiovascular disease. Despite increasing evidence supporting its benefits, many young patients remain insufficiently active...

Navigation Bronchoscopy Specific Cone-Beam CT Software Enabling Pre- And Intraprocedural Guidance

BACKGROUND: Cone-beam computed tomography (CBCT)- guided bronchoscopy is an established technique for diagnosing peripheral pulmonary lesions, offering 3-dimensional imaging for both navigation and confirmation. However, its usability as a stand-alone modality is limited by a sub...

Factors affecting family consent to corneal donation at a hospital-based eye bank in a tertiary Israeli medical center

Purpose To identify clinical, demographic, and situational factors associated with family consent to corneal donation in a culturally diverse Israeli medical center operating under an opt-in system. Methods This retrospective observational study included 824 deceased individuals...

Blended Care in the mCIMT-BiT Pirate Group in Children with Unilateral Cerebral Palsy: A Feasibility Study

Aims Intensive upper limb rehabilitation is essential for children with unilateral cerebral palsy (uCP). Home-based training may extend practice opportunities and reduce logistical barriers. This study examined the feasibility of a blended care approach in the mCIMT-BiT Pirate gr...

Prevalence of severe functional limitations and physical therapy use in patients with rheumatoid arthritis or axial spondyloarthritis: a multicentre cross-sectional study in the Netherlands

OBJECTIVE: To inform implementation of a long-standing, personalized exercise therapy programme in patients with rheumatoid arthritis (RA) and axial spondyloarthritis (axSpA) and severe functional limitations, we estimated the prevalence of severe functional limitations and descr...

Enhancing detection of polygenic adaptation: a comparative study of machine learning and statistical approaches using simulated evolve-and-resequence data

Abstract Background Detecting signals of polygenic adaptation remains a significant challenge in population genomics, as traditional methods often struggle to identify the associated subtle, multi-locus allele-frequency shifts. Here, we introduced and tested several novel approac...

Time-dependent prognostic value of coronary plaque burden and hyperemic myocardial blood flow

Abstract Rationale The time-dependent contributions of coronary atherosclerotic plaque burden and myocardial ischemia to clinical outcomes in suspected coronary artery disease (CAD) remain uncertain. This study aimed to evaluate the temporal associations of quantitatively assesse...

From policy debate to empirical evidence: a proof-of-concept bibliometric and LLM-assisted abstract-level content analysis of OTC hearing aid research before and after FDA regulation

Objective To characterise temporal patterns in over-the-counter (OTC) hearing-aid research before and after U.S. Food and Drug Administration (FDA) implementation of the OTC category (effective October 2022), using bibliometrics and large language model (LLM)–assisted abstract-le...

Long-term patient-reported knee-related outcomes and quality of life of patients with tibial plateau fractures: A mixed-methods study

Abstract Purposes This study aims to 1) provide a comprehensive assessment of the long-term functional outcomes in patients who sustained a tibial plateau fracture by combining patient-reported outcomes and a qualitative analysis of their healthcare experiences and 2) compare the...

Energetic cost of weight shifting and asymmetric weight-bearing during standing in humans

During prolonged standing, humans commonly shift their weight and spontaneously alternate between symmetric and highly asymmetric standing, bearing most of their body weight on one leg. Here, we tested the hypothesis that humans adopt asymmetric weight-bearing to reduce metabolic...

Response to Comment on: “Treatment of therapy-related acute myeloid leukemia and acute myeloid leukemia with myelodysplasiarelated changes: a comparative analysis of higher-dose intensive 7+3 induction chemotherapy versus liposomal cytarabine and daunorubicin”

Not available.

China-associated concentrations in gold open-access publishing: growth in APC exposure and business risk across twelve publisher groups

Commercial open-access publishing increasingly depends on research output from China, and this creates potential concentration exposure for major Western publishers. This work uses OpenAlex to analyse gold open-access articles and estimated list-price article processing charge (A...

Estimating differing causal roles of glutamate and GABA genes on brain and behavior in autism

Abstract The excitatory/inhibitory (E/I) imbalance theory suggests that excitatory and inhibitory alterations underlies autism characteristics. However, genetic underpinnings of this imbalance and its impact on brain function and behavior remains unclear. We explored causal links...

P1.157. International Comparison of Clinicopathologic Characteristics and Outcomes After Minimally Invasive transCervical Esophagectomy (MICE): A Retrospective Cohort Study

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer Background Minimally Invasive transCervical Esophagectomy (MICE) avoids a thoracic approach via transcervical mediastinal and abdominal dissection. Preserving pleural integrity may reduce pulmonary complica...

Resilience and adaptation of cancer screening programs to external crises

Objectives To examine how cancer screening programs resumed during the COVID-19 pandemic, focusing on their resilience in terms of coordination, communication, recovery, participation rates, catch-up efforts, inequities, and preparedness. Setting Cancer screening programs represe...

Prevalence and outcome of metastases to the thyroid gland: a nationwide database study

OBJECTIVE: Metastases to the thyroid are seen relatively often in autopsy studies. In clinical studies they are described as a rare occurrence. This study aims to provide a more extensive representation of the origin, timing and survival of patients diagnosed with metastases to t...

Efficacy and tolerability of venetoclax plus rituximab in relapsed or refractory chronic lymphocytic leukemia – real-world analysis of Polish adult leukemia study group

We collected clinical data on 363 patients with relapsed/refractory chronic lymphocytic leukemia (RR-CLL) treated with venetoclax-rituximab (VR) in a real-world setting. The median age was 69.5 years (range, 32.5–91.6 years), and the median number of prior lines of therapy was 2...

Patients’ and clinicians’ perspectives on telemedicine to monitor patients on systemic treatment for psoriasis or atopic dermatitis - a mixed methods study

Background For patients with stable psoriasis or atopic dermatitis (AD) receiving systemic treatment, telemedicine may offer a viable alternative to in-person consultations. However, perspectives of these patients and dermatological care providers (DCPs) regarding telemedicine ar...