University Hospitals of Cleveland

Redefining Kidney Stone Incidence: Emerging Age-Related Patterns

OBJECTIVE: To evaluate the association between age and incident kidney stone disease using contemporary, age- and sex-stratified population-based data from the UK Biobank. METHODS: We undertook a cohort study of 494,745 UK Biobank participants after excluding 7406 individuals wit...

Trends in Ophthalmic Hospital Transfers and Consultations Across US Academic Centers

Importance Academic medical centers increasingly serve as a safety net for urgent and complex ophthalmic conditions, yet trends in the demand for hospital-based ophthalmic services remain poorly characterized. Objective To characterize multi-institutional trends in ophthalmology...

Childbirth, Sexual Function, and Sexual Distress Among Women: An Updated Review

Abstract Purpose of review The aim of this review was to examine the recent empirical literature on the association between childbirth and postpartum sexual function. Recent findings A total of 72 articles were reviewed. Many studies focused on the role of medical aspects of chil...

Associations between substance use by type and HIV viral suppression across multiple cohorts in the US

Substance use among people with HIV (PWH) represents an important obstacle to further reductions in HIV transmission. Using data from a diverse collection of five studies including people with HIV in care and those in community cohorts, we report results for analyses of the assoc...

Systemic inflammation, gut microbiome composition, and cognitive performance among older Ugandans with Alzheimer’s disease and related dementias

Systemic inflammation is implicated in neurodegeneration; however, evidence linking circulating inflammatory biomarkers to cognitive decline remains inconsistent, particularly in low- and middle-income countries. High-sensitivity C-reactive protein (hs-CRP) is a standard systemic...

In Vitro Terbinafine Susceptibility of Dermatophytes and Mycological Cure Outcomes from a Multicenter Phase III Onychomycosis Trial

Background: Dermatophyte infections, including onychomycosis, affect millions worldwide. Terbinafine, an allylamine antifungal, remains a foundational method of treatment. Objective: We aim to evaluate the in vitro antifungal susceptibility of terbinafine against dermatophyte iso...

Utility of the APE 2 Score as a Diagnostic Tool for Autoimmune Encephalitis

ABSTRACT Objective To retrospectively evaluate the diagnostic performance of the Antibody Prevalence in Epilepsy and Encephalopathy (APE 2 ) score relative to clinician‐adjudicated autoimmune encephalitis (AE) and the Graus criteria in a tertiary neuroimmunology referral cohort,...

Coated or chewable Aspirin and a hybrid air pollution mitigation strategy in patients with atherosclerotic disease: Rationale and Design of the COATED-AIR Randomized Trial.

BACKGROUND: Although enteric-coated aspirin is widely used instead of chewable formulations in patients with atherosclerotic cardiovascular diseases (ASCVD), its effects on cardiovascular and gastrointestinal outcomes remain uncertain. Separately, air pollution is a driver of car...

Association between chiropractic spinal manipulation and adverse vascular events of the head and neck: systematic review and meta-analysis

Abstract Background Observational studies have raised concerns about a potential association between chiropractic spinal manipulation (CSM) and craniocervical vascular events (CCVE), including cervical artery dissection and stroke. We tested the null hypothesis of no significant...

Promoting Optimal Pediatric Readiness at US Trauma Centers: Understanding and Addressing Barriers

Children treated at facilities prepared to provide emergency pediatric care have improved outcomes, but access to pediatric-ready care remains inconsistent. A multidisciplinary spotlight session at the 2026 American College of Surgeons Committee on Trauma Annual Meeting examined...

Deep Brain Stimulation: A Window Into the Neural Mechanisms of Latent Nystagmus

Purpose: Latent nystagmus is a condition marked by a nasal-ward drift of the eye that reverses depending on the fixating eye. It is commonly associated with early-onset strabismus and amblyopia and is hypothesized to result from disrupted horizontal binocular connections in the p...

Gastrointestinal Bleeding Is Associated with Worse In-Hospital Outcomes in Patients with ST-Segment Elevation Myocardial Infarction: An Analysis of the National Inpatient Sample

Background/Objectives: Patients with ST-segment elevation myocardial infarction (STEMI) may develop gastrointestinal (GI) bleeding. We aimed to assess the impact of GI bleeding on in-hospital outcomes in patients with STEMI. Methods: This retrospective study was performed using t...

Alcohol Use Disorder Is Associated With Higher Rates of Adverse Events, Readmissions, and Costs of Care Within 90 Days of Arthroscopic Rotator Cuff Repair

Purpose To determine whether alcohol use disorder (AUD) patients undergoing arthroscopic rotator cuff repair (ARCR) have higher rates of (1) medical complications, (2) readmission rates, and (3) costs of care. Methods A retrospective review of a private insurance payor was perfor...

Ipsilateral epistaxis in a patient with episodic cluster headache

Juan Fernando Ortiz, Camila D. Lopez, Romina Ballagan Escobar, and Nicholas J. Lannen declare no conflicts of interest relevant to this article.

Infliximab for the Treatment of Immune Checkpoint Inhibitor-Associated Acute Kidney Injury

Rishi R Patel, Katherine E Myers, Matthew M Mirsky, Iris Sheng, Arash Rashidi; Infliximab for the Treatment of Immune Checkpoint Inhibitor-Associated Acute

Cardiac imaging biomarkers of heart failure in diabetes for phenotyping, risk stratification, and evaluating therapeutic response

Type 2 diabetes mellitus (T2DM) is a well-established risk factor for the development of heart failure (HF), yet HF risk within this population is highly heterogeneous. Appropriate biomarker selection and a limited mechanistic understanding of the phenotypic subtypes of HF in T2D...

Laser Interstitial Thermal Therapy for Brain Tumors: A Prospective Multicenter Analysis of Patients From the LAANTERN Study

Background: Laser interstitial thermal therapy is a surgical tool used to ablate brain tumors, radiation necrosis, and epileptic foci. Data from the completed LAANTERN prospective multicenter registry (NCT02392078), containing tumor patients enrolled in the study across 25 US cen...

Adjunctive oral naltrexone for breakthrough craving in patients receiving extended-release injectable naltrexone for alcohol use disorder: Three cases

Craving is a subjective, poorly characterized phenomenon strongly associated with return to use in alcohol use disorder and remains difficult to manage. Extended-release naltrexone is a U.S. Food and Drug Administration–approved, evidence-based treatment, yet some patients experi...

Blood pressure Time in Target Range and Clinical Outcomes in Chronic Kidney Disease

BACKGROUND: We examined the association between blood pressure (BP) time in target range and clinical outcomes in chronic kidney disease (CKD). METHODS: In 1908 participants in the Chronic Renal Insufficiency Cohort study who had BP measured at each visit for the first five years...

Two-year outcomes following concomitant ACL and extra-articular ligament reconstruction: a nationwide analysis of over 5,000 patients

PURPOSE: The anterior cruciate ligament (ACL) is the most commonly injured and reconstruction ligament in the United States. Associated injuries are common, oftentimes including components of the extra-articular knee. However, complications following concomitant ACL and extra-art...