University Hospitals of Cleveland

Laser Interstitial Thermal Therapy for Brain Tumors: A Prospective Multicenter Analysis of Patients From the LAANTERN Study

Background: Laser interstitial thermal therapy is a surgical tool used to ablate brain tumors, radiation necrosis, and epileptic foci. Data from the completed LAANTERN prospective multicenter registry (NCT02392078), containing tumor patients enrolled in the study across 25 US cen...

Adjunctive oral naltrexone for breakthrough craving in patients receiving extended-release injectable naltrexone for alcohol use disorder: Three cases

Craving is a subjective, poorly characterized phenomenon strongly associated with return to use in alcohol use disorder and remains difficult to manage. Extended-release naltrexone is a U.S. Food and Drug Administration–approved, evidence-based treatment, yet some patients experi...

Blood pressure Time in Target Range and Clinical Outcomes in Chronic Kidney Disease

BACKGROUND: We examined the association between blood pressure (BP) time in target range and clinical outcomes in chronic kidney disease (CKD). METHODS: In 1908 participants in the Chronic Renal Insufficiency Cohort study who had BP measured at each visit for the first five years...

Two-year outcomes following concomitant ACL and extra-articular ligament reconstruction: a nationwide analysis of over 5,000 patients

PURPOSE: The anterior cruciate ligament (ACL) is the most commonly injured and reconstruction ligament in the United States. Associated injuries are common, oftentimes including components of the extra-articular knee. However, complications following concomitant ACL and extra-art...

A rapid approach to detect methicillin-resistant and susceptible Staphylococcus aureus directly from clinical specimens

ABSTRACT Screening of methicillin-resistant/susceptible Staphylococcus aureus (MRSA/MSSA) is important for healthcare facilities to prevent hospital-acquired infections. The two common MRSA screening approaches are culture-based testing with selective and/or differential properti...

Reflux symptom burden and objective findings at long-term follow-up after peroral endoscopic myotomy

BACKGROUND: Peroral endoscopic myotomy (POEM) effectively treats achalasia but confers a significant risk of postoperative gastroesophageal reflux. Studies demonstrate poor short-term correlation between reflux symptoms and objective findings, but long-term outcomes remain unclea...