University Hospital Schleswig-Holstein

Capturing of interdental areas with digital and conventional impression systems and their impact on automatic tooth segmentation in CAD software: an in vitro study

OBJECTIVES: This in vitro study evaluated and compared the accuracy of digital versus conventional impression systems in reproducing interdental areas (IAs) of periodontally compromised dentitions (PCDs) and examined how impression quality influences automated tooth segmentation...

DECIDER-2: Prospective randomized multicenter phase III trial of decitabine and venetoclax administered in combination with all-trans retinoic acid or placebo in patients with acute myeloid leukemia who are ineligible for induction chemotherapy

Abstract Background Acute myeloid leukemia (AML) is predominantly a disease of older patients with a poor long-term survival. Approval of the combination of venetoclax (VEN) with azacitidine (AZA) or decitabine (DAC) in the European Union in 2021 for the treatment of patients wit...

EFECT enables reliable and reproducible stochastic simulations across disciplines

Stochastic simulations underpin computational research in fields from systems biology and epidemiology to finance and physics-informed machine learning, yet their reproducibility is hard to quantify because each run yields different outcomes. Existing practices to improve computa...

Minced cartilage implantation for cartilage regeneration: a survey of current clinical practices

INTRODUCTION: The objective of this study is to evaluate how minced cartilage implantation (MCI) is currently applied in clinical settings, focusing on the selection criteria, procedural execution, handling of concomitant joint pathologies, and postoperative management. MATERIAL...

Sensory data-driven classification of complex regional pain syndrome: a multicentre cohort study

BACKGROUND: The underlying pathophysiological mechanisms of complex regional pain syndrome (CRPS) have been under debate in recent years. Previous studies identified mechanistic CRPS subtypes, which were characterised as 'cold' and 'warm' or peripheral and central phenotypes. Our...