University Hospital Regensburg

Patient-Reported Tolerability, Treatment Initiation, and Discontinuation of Postoperative Progestin Therapy After Cesarean Scar Repair in Women Planning Pregnancy

Background and Objectives: Cesarean scar disorder (CSDi) may require surgical repair in women with a large niche and thin residual myometrium. At our center, temporary postoperative progestin therapy is recommended to suppress cyclic endometrial proliferation and menstrual activi...

Interferon-λ inhibits immunopathology and boosts T cell–mediated immunity in a mouse model of mucosal viral infection

Interferon lambda (IFN-λ) has emerged as a critical inducer of immune regulation in addition to its mucosal antiviral properties. However, the cellular and molecular mechanisms that govern its dual role during viral infections remain unclear. Here, we discovered that mucosal deli...

Molecular characterization of colorectal cancer liver metastases with pure desmoplastic versus non-pure desmoplastic histopathological growth patterns using a targeted gene expression panel

The histological growth pattern (HGP) at the interface of colorectal adenocarcinoma liver metastases (CRCLM) and liver parenchyma provides important prognostic information. This study aimed to identify transcriptomic signatures underlying the predominant HGPs in CRCLM. We retrosp...

Structures and objectives of day hospices – Design of a logic model

Abstract Background Day hospices represent a new component of outpatient palliative care in Germany. They focus on improving the quality of life and symptom control for patients with advanced, incurable diseases and aim to relieve the burden on family caregivers. However, a unifo...

Myeloid cell reprogramming drives enhanced defense against Streptococcus pneumoniae lung infection following exposure to commensal Prevotella

Clinical data link the prevalent respiratory tract anaerobe Prevotella with reduced pneumonia mortality, but the mechanisms directing Prevotella regulation of lung immune homeostasis are unclear. Here, single-cell RNA sequencing was employed to define the transcriptional immune s...

Intraoperative monitoring of malignant liver tumor microwave ablation using contrast-enhanced ultrasound: A preliminary study

Objective This study aimed to evaluate intraoperative assessment and monitoring of liver tumor ablations using contrast-enhanced ultrasound (CEUS). Methods Twenty patients (11 males [65%] and 9 females [45%]) with malignant lesions (cholangiocellular carcinoma (CCC), 1; hepatocel...

Comparison Between Skeletally‐Anchored and Conventional Maxillary Protraction in Growing Class ΙΙΙ Patients: A Systematic Review and Meta‐Analysis

ABSTRACT Objective The aim of this systematic review was to evaluate the skeletal and dental effects of skeletally‐anchored (SA) maxillary protraction compared with conventional facemask (FM) therapy in growing patients with Class III malocclusion, while controlling for the confo...

Long-term reprogramming of classical monocytes with altered ontogeny mediates enhanced lung injury in sepsis survivors

Patients who survive sepsis are predisposed to new hospitalizations for respiratory failure, but the underlying mechanisms are unknown. Using a murine model in which prior sepsis predisposes to enhanced lung injury, we previously discovered that classical monocytes persist in the...

Cutaneous Deterioration Following Glucocorticoid Discontinuation in Psoriatic Arthritis: A Real-World Cohort Study

Background/Objectives: To evaluate the frequency of documented cutaneous deterioration within three months after complete discontinuation of systemic glucocorticoid therapy in psoriatic arthritis (PsA) and to assess a potential association with cumulative glucocorticoid exposure....

Real-world use of bempedoic acid for hypercholesterolaemia: a German multicentre, retrospective, cohort study

Abstract Background Dyslipidaemia remains a leading cause of death in Germany despite an improving therapeutic landscape, with many patients not achieving guideline-recommended low-density lipoprotein cholesterol (LDL-C) goals. Bempedoic acid, an adenosine triphosphate citrate ly...

Coverage and adherence to the German childhood vaccination schedule: results from the KUNO-Kids health study

In Germany, the childhood vaccination schedule in 2015–2020 included 13 vaccines, for which primary immunization series was recommended to be completed by 24 months of age. Childhood vaccination coverage is monitored through health insurance claims data and pre-school entry exami...

How Long and How We Judge Age: A Cross-Racial and Cross-Gender Eye-Tracking Investigation

Abstract Background Facial aging results from genetic, environmental, and lifestyle factors, leading to wrinkles, volume loss, and contour changes. These alterations affect perceived age, attractiveness, and self-image. Eye-tracking technology provides insights into gaze patterns...

Prevention and Management of Tooth Discolouration of Endodontic Origin ( DEO ): A State‐of‐the‐Art Review

ABSTRACT Background Tooth discolouration of endodontic origin (DEO) refers to an undesirable change in tooth colour arising from the pulp space as a result of reactive physiological processes, pathological processes or endodontic procedures and materials. As DEO frequently affect...

Investigating long-term quality of life and depressive symptoms following fracture-related infection: a systematic review with meta-analysis of heterogeneous evidence

Background : Fracture-related infection (FRI) is associated with prolonged treatment courses and functional impairment. However, the long-term effects of FRI on quality of life (QoL) and psychological outcomes remain unclear. Methods : A PRISMA-compliant systematic review of PubM...

Divergent c-MYC Expression Patterns in NET and NEC: Insights from a Multicentre Cohort of 1380 Neuroendocrine Neoplasms

Abstract Neuroendocrine neoplasms (NEN) comprise well-differentiated neuroendocrine tumours (NET) and neuroendocrine carcinomas (NEC), whose distinction is clinically critical. Although c-MYC alterations have been implicated in NEC pathogenesis, c-MYC expression across NEC subtyp...

Factors associated with drug adherence in psoriasis: a single‐center, retrospective, questionnaire‐based exploratory study in Bavaria

BACKGROUND AND OBJECTIVES: Achieving sustained drug adherence in psoriasis remains challenging despite effective therapies. This exploratory study aims to investigate the care situation and factors associated with drug adherence in patients with moderate-to-severe psoriasis vulga...

Change in COVID-19 outcomes in lymphoma patients across pandemic waves: results of the COVID-19-lymphoma registry of the Bavarian Cancer Research Center (BZKF) 2020–2022

Abstract Patients with malignant lymphomas are at increased risk for severe COVID-19. In the general population, outcomes of COVID-19 have improved dramatically over time due to increasing immunity through vaccination or infection and due to improved clinical care. It is unclear...

The fourth column in thoracic vertebral fractures: concomitant thoracic cage injuries and mortality in 27,814 inpatient cases from the german national DRG database

Abstract Purpose Population-level data on fourth column fractures and prognostic implications remain lacking. This study aimed to characterise the epidemiology of thoracic vertebral fractures in Germany, including the prevalence of fourth column injuries and geriatric patients, c...

Variation in meningioma recurrence risk estimates across observational cohorts: the influence of calendar time, WHO classifications, geographical settings, and healthcare systems

Abstract Purpose Recurrence risk estimates underpin meningioma research, including molecular classification and clinical trial benchmarking, yet are often based on retrospective or historical data. The aim of this study was to assess the variation of recurrence risk estimates acr...

Exploring the association between genetic polymorphisms in FGFR2 and children’s facial morphology

Abstract Background Studies on animal models and fibroblast growth factor receptor (FGFR2)-associated craniosynostosis syndromes suggest that FGFR2 plays a crucial role in craniofacial development. Therefore, the present exploratory study aims to investigate the relationship betw...