University Hospital Münster

Red blood cell transfusion is not associated with lymphocyte subpopulation counts in very low birthweight infants

BACKGROUND: Very low birthweight (VLBW) infants frequently require red blood cell (RBC) transfusions. Transfusions may modulate immune responses, but their impact on immune development remains incompletely understood. METHODS: 120 VLBW infants participating in the prospective "Im...

Disease Duration Differentiates Freezing of Gait Response to Subthalamic and Nigral Stimulation for Parkinson's Disease in an Exploratory Multicenter Controlled Trial

BACKGROUND: Freezing of gait (FoG) belongs to most pressing unmet symptoms in the treatment of Parkinson's disease. OBJECTIVES: To explore whether combined subthalamic and nigral (STN + SNr) deep brain stimulation improves FoG compared with optimized STN stimulation alone; to ide...

Modular Triethylene Glycol Decouples Antimicrobial Potency from Cytotoxicity in Membrane-Active Drugs

Abstract Cationic membrane-active drugs are an important focus of antibiotic research, yet their potential is often limited by poor selectivity. Here, we establish steric protection of cations by modular triethylene glycol as a chemical design framework to decouple antimicrobial...

Intracranial rescue stenting in the German stroke registry: a propensity score-matched multicenter study

Abstract Background Intracranial stenting (ICS) is used as a rescue strategy in patients with failed reperfusion after endovascular thrombectomy (EVT). However, real-world data on clinical outcomes and safety remain limited. Methods This retrospective analysis of prospectively co...

Outcomes of front-line tagraxofusp in patients with blastic plasmacytoid dendritic cell neoplasm (BPDCN) in a real-world scenario

Abstract Tagraxofusp (TAG), a CD123-directed protein-drug conjugate, is approved in front-line and relapsed/refractory blastic plasmacytoid dendritic cell neoplasm (BPDCN). Multicenter real-world outcomes and the contribution of up-front consolidation post-TAG remain less defined...

Intensive care infection score outperforms inflammatory biomarkers in detecting infection in critically ill patients

Identification of infection in critically ill patients remains challenging, as conventional biomarkers such as C-reactive protein (CRP), procalcitonin (PCT) and white blood cell count (WBC) frequently lack diagnostic accuracy. The Intensive Care Infection Score (ICIS), a host-res...

Intraoperative ventilation settings in Germany: an observational multicentre cross-sectional study

Intraoperative lung protective ventilation and, in inhalational anesthesia, minimal fresh gas flow (FGF) are recommended. It remains unclear how these recommendations are transferred to clinical routine. We aimed to assess corresponding anesthesia practices in Germany and raise a...

Adults with congenital heart disease: the growing impact of acquired cardiovascular risk factors on late mortality.

BACKGROUND AND AIMS: With improved survival, adults with congenital heart disease (ACHD) increasingly face acquired cardiovascular risk factors; however, their impact on late mortality remains incompletely defined. This study aimed to evaluate the contribution of acquired cardiov...

Congenital heart disease in adults: evolving health systems and lifelong outcomes.

Over the past decades, advances in the diagnosis and treatment of congenital heart disease have reshaped its epidemiology. Congenital heart disease is now increasingly a chronic, lifelong disorder, with adult survivors outnumbering affected children in many countries. This demogr...

Gut resilience and clinical homeostasis following administration of neomycin and albendazole in soil-transmitted helminth-infected adults living in Lambaréné, Gabon

Abstract Purpose Gut resilience and systemic homeostasis are interrelated dynamic functions. A gut that fails to regulate intestinal barrier integrity, metabolite production, and immune regulation will lead to systemic pathogenic invasion and susceptibility to infections. Gut res...

A multimodal manual therapy, exercise, and psychological intervention for painful diabetic neuropathy: the NeuOst feasibility randomised controlled trial.

Introduction: People with painful diabetic neuropathy lack effective and tolerable treatments. Physical and psychological interventions may help but require further study and combination to maximise effects. Objectives: This single-site, 3-arm, parallel, randomised feasibility tr...

Changes in retinal layer thickness during and after pregnancy in a healthy Caucasian cohort

Purpose Structural retinal changes have been reported in pregnant women compared with non-pregnant controls, yet longitudinal optical coherence tomography (OCT) data across pregnancy and postpartum are limited. This prospective study quantifies retinal OCT metrics in healthy preg...

Achieving physiologic distensibility targets frequently requires modification of standard cruroplasty during anti-reflux surgery

Abstract Background Intraoperative EndoFLIP provides objective assessment of esophagogastric junction (EGJ) distensibility during anti-reflux surgery, and final distensibility index (DI) values of 2.0–3.5 mm 2 /mmHg have been associated with improved reflux control while minimizi...

CD147 is associated with NF-κB activation during the post-traumatic immune response in a murine trauma model

Abstract Extracellular matrix metalloproteinase inducer (CD147) has been proven to play a crucial role in a variety of inflammatory diseases but has not yet been investigated in trauma. The aim of the study was to investigate the role of CD147 in a murine model of trauma and hemo...

Efficacy and Safety of Risankizumab in Paediatric Patients With Psoriasis in the OptIMMize-1 Phase III Study.

BACKGROUND: Treatment options for paediatric patients with psoriasis are limited, and additional, more advanced therapies are needed. Risankizumab is an interleukin-23 inhibitor approved to treat moderate-to-severe psoriasis in adults. OBJECTIVES: To evaluate efficacy and safety...

Comorbidities in individuals with intellectual disabilities with and without hearing loss: a prospective cohort study

Abstract Background Both intellectual disability (ID) and hearing loss (HL) are associated with a high prevalence of certain comorbidities. However, a combined analysis and overview classified according to the International Classification of Diseases, 11th Revision (ICD-11), is l...

Aortitis and inflammatory myopericardial syndrome after Chlamydia pneumoniae infection – A Case report

Abstract Background Inflammatory myopericardial syndrome (IMPS) is a major disease entity, particularly among younger male patients. The simultaneous occurrence of aortitis is uncommon but potentially life-threatening. Case Summary A 32-year-old male presented with acute tonsilli...

A multicenter randomized, double-blinded placebo-controlled phase 2 trial to evaluate safety and efficacy of ilofotase alfa in patients at risk for kidney injury following open heart surgery

Acute impairment of kidney function after cardiac surgery is common and associated with an increased morbidity and mortality. Ilofotase alfa has demonstrated potential to attenuate renal injury through its immunomodulatory effects. We evaluated the safety and efficacy of ilofotas...

Dosing and delivery of bacteriophage therapy in a murine wound infection model

Lytic bacteriophages, viruses that lyse (kill) bacteria, hold great promise for treating infections, including wound infections caused by antimicrobial-resistant Pseudomonas aeruginosa. However, dosing and delivery strategies for phage therapy remain underdeveloped. In a mouse wo...

Early Multicentre Outcomes of Endovascular Aortic Arch Repair Using a Custom-Made Triple-Branch NEXUS TRE Endograft System (TRE-ASURE Study)

Objective: To report the first multicentre European experience with the custom-made NEXUS TRE triple-branch endograft for fully endovascular, debranch-free repair of complex aortic arch pathology, focusing on technical feasibility and early safety outcomes. Methods: This retrospe...