University Hospital Münster

Clinical characteristics, treatment patterns, and survival outcomes in ductal prostate cancer: a multicenter retrospective analysis

Abstract Purpose Prostatic ductal adenocarcinoma (PDA) is a rare, aggressive prostate cancer subtype associated with advanced disease and poorer prognosis than acinar adenocarcinoma. Small ductal components influence management and preclude active surveillance. This study analyze...

Transport of cytotoxic cyanine dyes coupled to siRNA into hematopoietic cancer cells with CD20-, CD22- or CD33-targeting ELART nanocarriers

Abstract The efficient and safe transfection of hematopoietic cells is a major hurdle that limits efficacy of therapeutic approaches like RNA-interference. We therefore used our modular EL ectrostatic A ntibody si R NA T argeted therapy platform (ELART) to develop nanocarriers de...

The transcription factor NF-Y promotes myeloid cell survival and protects from inflammatory vascular disease

Abstract Background Myeloid cells orchestrate vascular inflammation through transcriptional programs that regulate their maturation, effector function, and survival. While lineage-determining transcription factors establish myeloid identity, understanding of the transcriptional r...

Acute kidney injury and renal replacement therapy: a critical synthesis of metabolic derangements and nutritional implications

Acute kidney injury (AKI) affects up to 50% of critically ill patients and is frequently complicated by severe metabolic derangements, requiring the initiation of replacement therapy (RRT) in 10–15% of cases. Despite substantial progress in the diagnosis of AKI and optimisation o...

Endothelial biomarkers predict kidney and cardiovascular outcomes after acute kidney injury

Abstract Background Acute kidney injury (AKI) is common in hospitalized patients, and post-injury biological processes activated after the initial insult may determine recovery or sustained damage. Identifying these processes may offer opportunities for early intervention, and bi...

Conservative and surgical treatment of wrist osteoarthritis: a systematic review

INTRODUCTION: Wrist osteoarthritis leads to pain and functional impairment. Despite conservative treatment options, surgery remains a central therapeutic component. In Germany, the number of patients rose from over 472,000 cases in 2018 to more than 580,000 in 2024. This review e...

Subgroup variations in effectiveness of femoropopliteal sirolimus versus paclitaxel-coated balloon angioplasty: post hoc results of the randomised SIRONA trial

INTRODUCTION: The randomised SIRONA trial showed that sirolimus-coated balloon (SCB) angioplasty was non-inferior to paclitaxel-coated balloon angioplasty (PCB) regarding femoropopliteal primary patency. There was no difference in clinically driven target lesion revascularisation...

Magnetic resonance imaging‐based axial‐plane analysis of lower extremity torsion with dedicated 3D planning software is reliable and efficient

PURPOSE: The reliability and efficiency of a dedicated 3D planning software were evaluated for magnetic resonance imaging (MRI)-based measurement of femoral torsion, tibial torsion, knee version and whole-lower extremity torsion compared with manual assessment. METHODS: In this r...

DECIDER-2: Prospective randomized multicenter phase III trial of decitabine and venetoclax administered in combination with all-trans retinoic acid or placebo in patients with acute myeloid leukemia who are ineligible for induction chemotherapy

Abstract Background Acute myeloid leukemia (AML) is predominantly a disease of older patients with a poor long-term survival. Approval of the combination of venetoclax (VEN) with azacitidine (AZA) or decitabine (DAC) in the European Union in 2021 for the treatment of patients wit...

Carboplatin/Paclitaxel can be an effective alternative for cisplatin-ineligible patients with locally advanced HNSCC

Abstract Background Despite considerable therapeutic advances, a significant evidence gap remains regarding optimal treatment strategies for cisplatin-unfit patients and whether carboplatin/paclitaxel represents a valid therapeutic alternative. This study investigates the treatme...

Sensory data-driven classification of complex regional pain syndrome: a multicentre cohort study

BACKGROUND: The underlying pathophysiological mechanisms of complex regional pain syndrome (CRPS) have been under debate in recent years. Previous studies identified mechanistic CRPS subtypes, which were characterised as 'cold' and 'warm' or peripheral and central phenotypes. Our...

Is 3 really better than 2? In vivo functional calcium imaging of cortical circuits by two- and three-photon microscopy

This study explores the capability of three-photon functional imaging to resolve functional cortical architecture in mice. By a quantitative, back-to-back comparison in awake head-fixed mice, we demonstrate that three-photon imaging is equally capable compared to two-photon imagi...