University Health Network

Hematologic Malignancy Prevalence in Hidradenitis Suppurativa: A Cross-Sectional Study

Background: Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease associated with substantial comorbidity. Evidence regarding the co-occurrence of HS and recorded hematologic malignancy diagnoses in large, diverse electronic health record populations remains limite...

Spatial transcriptomic analysis of progressing oral epithelial dysplasia reveals unique differentially expressed genes and microenvironmental changes.

Oral squamous cell carcinoma (OSCC) often arises from oral epithelial dysplasia (OED); however, the gene expression changes during OED progression and its microenvironment are not fully understood. This study used spatial transcriptomics to identify differentially expressed genes...

Allosteric inhibition of human mitochondrial ClpP by hijacking the dordaviprone (ONC201) binding site

ClpP protease maintains proteostasis in human mitochondria and is overexpressed in cancers such as acute myeloid leukemia (AML). While activators such as dordaviprone (ONC201) have reached the clinic, the development of ClpP inhibitors has been hampered by paradoxical activation...

Maternal and Fetal Outcomes in Mice Following Exposure to Dolutegravir Alone or in Combination with Lamivudine or Tenofovir Disoproxil Fumarate/Emtricitabine

Abstract Background and Aims Dolutegravir (DTG)-based regimens are widely used in HIV treatment, including during pregnancy, but the contribution of the nucleoside reverse transcriptase inhibitor (NRTI) backbone on maternal and foetal outcomes remains unclear. We examined this in...

Gastric Outlet Obstruction Secondary to Cholecystoduodenal Fistula With Gallstone-Induced Extrinsic Duodenal Compression

ABSTRACT Gastric outlet obstruction (GOO) caused by gallstone disease is rare and typically results from the Bouveret syndrome, with intraluminal gallstone impaction following cholecystoenteric fistula formation. We report a 69-year-old woman with GOO caused by extrinsic duodenal...

Co-designing a financial navigator program in the neonatal neurodevelopmental follow-up clinic: a formative mixed-methods study

Families of infants requiring neonatal intensive care often experience substantial financial hardship due to income loss and out-of-pocket costs during hospitalization and after discharge. Hospitals currently lack dedicated, structured support to help families navigate these fina...

Clinical Improvement, No Improvement, and Worsening at 24 Hours Following Reperfusion in Patients With Stroke due to Large-Vessel Occlusion

BACKGROUND: Restoring blood flow to ischemic tissue is the cornerstone of acute stroke therapy and is usually beneficial. However, when reperfusion is achieved for severely injured tissue, it is often futile and may occasionally cause harm. We aim to determine the prevalence and...

Neuroradiological spectrum of sarcoma intracranial metastases: a single center study

Sarcomas are a heterogeneous group of rare tumors sharing a common origin from connective or other non-epithelial tissues. Although clinical case series of intracranial sarcoma metastases have already been published, their neuroradiological findings are poorly known. This study a...

Association of lipid-frailty composite indices with cardiovascular disease risk in individuals with cardiovascular-kidney-metabolic syndrome stages 0–3: evidence from the UK Biobank and CHARLS

Non-traditional lipid indices have been increasingly investigated as predictors of cardiovascular disease (CVD) risk, and frailty reflects cumulative physiological decline. Whether integrating these complementary dimensions improves CVD risk prediction remains unexplored. We aime...

Antioxidant premedication reduces mitochondrial and nuclear DNA damage repair in interventional physicians performing X-ray-guided angiography procedures: a pilot clinical intervention study

Abstract Background To examine effects of naturally occurring antioxidants on DNA damage repair acute responses of ionizing radiation sustained by interventional physicians during angiography. Methods The study cohort included 20 interventional physicians (19 males, 1 female; mea...

Performance and safety of a multi-cancer early detection test: the PATHFINDER 2 study

Abstract Early cancer detection improves survival; however, most cancer types do not have guideline-recommended screening. We previously reported the first PATHFINDER study that established feasibility of cancer screening with a blood-based multi-cancer early detection (MCED) tes...

Crystalline maculopathy as a clue to a neurocutaneous syndrome

PURPOSE: To describe crystalline maculopathy as a diagnostic clue to Sjögren-Larsson syndrome (SLS) and highlight characteristic multimodal imaging findings. METHODS: Case Review. RESULTS: Using multimodal imaging, including OCT and fundus autofluorescence, we provide detailed st...

A multi-site loiasis dataset of whole blood videos

Loiasis is a blood-borne filarial infection under consideration for inclusion in the WHO’s priority list of Neglected Tropical Diseases. In addition to its direct impact on human health, loiasis frequently occurs as a co-infection with other filarial diseases, including onchocerc...

Optimized Brain Functional MRI for Patients With Deep Brain Stimulation Systems

BACKGROUND AND OBJECTIVES: Deep brain stimulation (DBS) is an established neuromodulation therapy for Parkinson disease and other neurological disorders. Active DBS–functional MRI (fMRI) enables visualization of circuit engagement and may provide objective biomarkers of therapeut...

High rates of transition to immune active disease in a cohort of strictly defined immune tolerant patients with chronic hepatitis B: results from the RADICAL consortium

Background Patients with immune tolerant (IT) chronic hepatitis B (CHB) have high viral loads, minimal inflammation and minimal fibrosis. Nevertheless, the benign nature of this phase and the need for antiviral therapy remain controversial. Objective We explored the natural histo...

Conceptualizations of compassion in the context of dementia caregiving: A scoping review protocol

Background Compassion is widely recognized as a vital component of dementia caregiving, yet its conceptualization, definition, and operationalization remain inconsistent across contexts. In dementia caregiving, compassion is often conflated with empathy, emotional labor, and rela...

“Updates on diagnostic and prognostic molecular biomarkers of CNS tumors”

The diagnosis and classification of central nervous system (CNS) tumors has undergone a paradigm shift over the past decade, evolving from a purely histology-based approach to an integrated framework that incorporates molecular and epigenetic features. This review summarizes rece...

Redesigning 9-1-1 Paramedic Pathways: Evaluation of the IMPACC Model of Care

OBJECTIVES Paramedic services remain organized around rapid response, time-sensitive events, and hospital conveyance despite increasing 9-1-1 use for lower-acuity and undifferentiated presentations. There is a need to improve the alignment of paramedic services for patients seeki...

Biliary complications in pediatric living donor liver transplantation: An international multicenter analysis of risk and prognostic factors

Biliary reconstruction is often considered the Achilles’ heel of liver transplantation, yet risk factors and outcomes remain poorly defined, particularly in pediatric living donor liver transplantation (LDLT). This international multicenter study aims to identify predictors of bi...

Modeling the Exposome in Murine Cardiovascular Disease

Our exposome, encompassing our environmental and lifestyle exposures across the life span, is a critical determinant of cardiovascular health. Clinical and epidemiological data demonstrate that sleep, stress, exercise, smoking, viral respiratory infections, and environmental poll...