University Foundation

Vitamin D in coronary heart disease: a Mendelian randomization meta-analysis of data stratified by 25(OH)D levels

Maria Fusaro, Pasquale Perrone Filardi, Gianfranco Sinagra, Maria Luisa Brandi, Maurizio Gallieni, Jean-Yves Reginster, Eugene McCloskey, Etienne Cavalier,

NAMING THE RESOLUTION Spatial, Phase, Chirality, and Infratier Structure Four Connected Terms for Generator-Resolved Closure Physics

Spatial → Spatial–Phase → Spatial–Phase–Chirality → Spatial–Phase–Chirality–Infratier P → S | S → SP → SPC → SPCI As a physical framework develops, terminology adequate at one stage can become ambiguous at a later stage. This is particularly true when a single expression is asked...

Phase Algebra and Phase Calculus

Coherence becomes relation through phase. Relation becomes active through resonance. Resonance becomes persistent through cohesion. Persistence becomes lawful through invariant transformation. Recoherence gathers difference without erasing it. Phase Algebra and Phase Calculus Thi...

The Paradox of Unprovable Theories and the Ontological Limits of Physics

This work examines a recurring structural problem in modern theory-building: the attempt to explain phenomena whose truth conditions lie outside the coherence band available to the observer who must test them. In contemporary physics and cosmology, this problem appears repeatedly...

The Paradox of Unprovable Theories Coherence Layers, Measurement-Closure And the Ontological Limits of Physics

This work examines a recurring structural problem in modern theory-building: the attempt to explain phenomena whose truth conditions lie outside the coherence band available to the observer who must test them. In contemporary physics and cosmology, this problem appears repeatedly...

Panspatial Biogenesis - The_Geometry_of_Genesis__Deriving_Life_from_First_Principles

Biological emergence is geometrically admissible before it is chemically expressed. Within the Panspatial Genesis framework, life is not an accidental late product of molecular complexity alone, but is the adaptive expression of a deeper closure architecture. Life becomes possibl...

Panspatial Biogenesis - The_Geometry_of_Genesis__Deriving_Life_from_First_Principles

Biological emergence is geometrically admissible before it is chemically expressed. Within the Panspatial Genesis framework, life is not an accidental late product of molecular complexity alone, but is the adaptive expression of a deeper closure architecture. Life becomes possibl...

THE LIGHTCONE AS A CLOSURE BOUNDARY Minimal Relational Orientation, Grade-Dual Lorentzian Structure, and Null-Rank Protection

Foundational Quantum Mechanics · Spacetime Invariants · Geometric Algebra The lightcone is normally introduced within an already Lorentzian spacetime as the null locus ds² = 0. Within special relativity, relativistic field theory, and quantum electrodynamics, this structure separ...

FROM COHERENCE TO DISCLOSURE Phase, Resonance, Cohesion, and Future-Sufficient Physical Computation

Quantum Computational Theory + exact analytic study + preregistered computational benchmark protocol Central thesis For a specified future task, physical protection need preserve only those relational distinctions whose loss can still alter that future through the remaining dynam...

THE LIGHTCONE AS A CLOSURE BOUNDARY Minimal Relational Orientation, Grade-Dual Lorentzian Structure, and Null-Rank Protection

Foundational Quantum Mechanics · Spacetime Invariants · Geometric Algebra The lightcone is normally introduced within an already Lorentzian spacetime as the null locus ds² = 0. Within special relativity, relativistic field theory, and quantum electrodynamics, this structure separ...

Quantum Worldhood as Partial Closure Many Worlds, the Multiverse and the Emergence of Classical World Labels

This Zenodo release preserves the completed manuscript together with one additional formal development that emerged during final production: the Closure-Multiverse Existence Theorem. The principal manuscript develops quantum worldhood through Partial Closure. Its central mathemat...

From PSOC4 to Electroweak Resolution Generator Levels, Null Coherence, and the 4 → 7 → 15 Closure Architecture A Closure-Theoretic Bridge Between Phase-Spatial Worldhood, Internal Gauge Structure, and the Shared Null Phase

This paper develops a closure-theoretic interpretation of the relation between a four-generator phase-spatial structure, a seven-generator electroweak-capable resolution level, and a fifteen-generator SU(4)-scale algebraic envelope. The central distinction is between generator re...

Future-Sufficient Control Quotients Robust Closure, Operational Reduction, and Physical Realization

A task-relative theory of what may be forgotten, what may be ignored in practice, and what need not be physically maintained Reduced representations can be sufficient in at least three inequivalent senses: they may close under a declared family of future continuations, support ne...

FROM TRIALITY TO GENERATOR RESOLUTION S₃ Augmentation, Determinant Closure, and the Emergence of a 3 + 2 Mode Architecture

Why should a group containing only six permutations have anything to do with the richer continuous symmetries used in physics? The reconstruction developed here answers by refusing to treat S₃ as a small version of a gauge group. S₃ instead describes something more primitive: thr...

CPT as Composite Symmetry Closure From Constituent Symmetry Violation to Relational Invariance

This paper asks when that survival is mathematically exact, physically faithful, and experimentally testable. For a reader coming to CPT for the first time, the letters can make the subject look more mysterious than it is. C denotes charge conjugation, P parity, and T time revers...

Future-Sufficient Control Quotients Robust Closure, Operational Reduction, and Physical Realization

A task-relative theory of what may be forgotten, what may be ignored in practice, and what need not be physically maintained Reduced representations can be sufficient in at least three inequivalent senses: they may close under a declared family of future continuations, support ne...

CLOSURE MATHEMATICS AND THE CONSTRUCTION OF WORLDS — V From Agency to Cognitive Worldhood

Cognition is often characterized through memory, prediction, control, internal models, abstraction, or flexible behavior, but these capacities need not coincide. A system can retain information without constructing a world model, predict without preserving causal or counterfactua...

FROM TRIALITY TO GENERATOR RESOLUTION S₃ Augmentation, Determinant Closure, and the Emergence of a 3 + 2 Mode Architecture

Why should a group containing only six permutations have anything to do with the richer continuous symmetries used in physics? The reconstruction developed here answers by refusing to treat S₃ as a small version of a gauge group. S₃ instead describes something more primitive: thr...

From PSOC4 to Electroweak Resolution Generator Levels, Null Coherence, and the 4 → 7 → 15 Closure Architecture A Closure-Theoretic Bridge Between Phase-Spatial Worldhood, Internal Gauge Structure, and the Shared Null Phase

This paper develops a closure-theoretic interpretation of the relation between a four-generator phase-spatial structure, a seven-generator electroweak-capable resolution level, and a fifteen-generator SU(4)-scale algebraic envelope. The central distinction is between generator re...

Creating Value Through History and The Future - The Evolution of Wealth, Work, Intelligence, and Value Creation

Wholonomics White Paper Series Core Disclosure Human history is the progressive amplification of value-creating agency. The future of economics depends on whether this amplified agency is directed toward extraction, coherence, or ultimately ontological wealth. This paper is not o...