University College Dublin

Aggregation framework for continuous digital health measures and application to walking activity data

Abstract No standardized procedures for aggregating continuous digital health measures exist. Using a modified Delphi approach, we developed a framework to standardize the selection of aggregations that provide clinically meaningful, stable values. This was applied to aggregate s...

Theory-informed substance use prevention for adolescents at risk: a scoping review of school and community interventions

Adolescence is a critical developmental period for the initiation of psychoactive substance use. Behaviour change theories are frequently used in prevention programmes, but their application across adolescent substance use prevention interventions has not been comprehensively map...

Structure and function of TM6SF1 reveals role in mTORC1 signaling

The transmembrane 6 superfamily (TM6SF) comprises two members: TM6SF1, a ubiquitously expressed lysosomal membrane protein of unknown function, and TM6SF2, an endoplasmic reticulum protein required for bulk lipidation of Apolipoprotein B–containing lipoproteins. Here, we used cry...

Historical, clinical and nasal endoscopic findings in 1600 cases of equine sinonasal disease and associations with case outcome

Abstract Background No large study has described the signalment, pre‐referral management or clinical and nasal endoscopic findings in equine sinonasal disease. Objectives To explore associations between case outcome and signalment, pre‐referral treatments, clinical and nasal endo...

Successful use of insect‐based ( Hermetia illucens ) diet in dogs with food‐responsive enteropathy

Objective Diet is an integral component of the management of chronic enteropathy in dogs. The role of insect‐based diets in this disease remains unknown. The objective of this study was to evaluate the impact of an insect‐based ( Hermetia illucens ) diet in dogs with presumed foo...

Analyzing policy implementation and industry engagement: the case of sachet alcohol regulation in Nigeria

Background Alcohol use is a growing public health concern in most LMICs, where weak regulatory systems operate alongside competing economic interests. While studies have documented the involvement of the alcohol industry in policy processes globally, evidence on these processes h...

Sociolinguists against the AI hype? AI tools in sociolinguistics scholarship

Abstract This paper examines sociolinguists’ views of and engagement with artificial intelligence technology in sociolinguistics scholarship, an area that has received little systematic attention to date. Drawing on a global survey of 274 respondents, the study reveals that while...

Transitioning from Degraded Peat to Paludiculture: Evidence-Based Roadmap for Research and Practice

Paludiculture, the sustainable productive use of wet and rewetted peat soils, offers a dual solution for preserving soil carbon and reducing greenhouse gas emissions whilst offering a form of income for landowners/farmers. However, establishing best practices for the transition t...

War and peace in the early 21st century: An introduction

This introductory article critiques dominant, teleological social science narratives that position organised violence as a declining historical phenomenon. Instead, it asserts the structural centrality of warfare as a primary catalyst for institutional, political and societal tra...

Fear Of cancer Recurrence Group-based intervEntion (FORGE): Study protocol for the co-design of a psychological intervention for young adult cancer survivors

Background Fear of cancer recurrence (FCR) represents one of the most frequently reported unmet needs among cancer survivors, with young adults demonstrating heightened susceptibility to its effects. Although a range of specialist-delivered psychological interventions has shown e...

Diagnosed causes of sinonasal disease in 1600 horses and associations with clinical signs, computed tomographic findings and case outcome

BACKGROUND: The diagnosis of equine sinonasal disorders has been greatly enhanced by using computed tomographic (CT) imaging. OBJECTIVES: To explore associations between specific diagnoses and clinical and CT findings and between specific diagnoses and case outcome in equine sino...

Capturing Fast Gas Migration in Proteins

Small gases pose an unusual problem for studies of molecular transport in proteins. O2, CO, H2, and NO can cross short-lived internal spaces opened by protein fluctuations, often faster than experiments can follow continuous migration. Time-resolved crystallography can localize s...

Influence of Manual Double-Spin Preparation Protocols on the Cellular and Growth Factor Composition of Equine Platelet-Rich Plasma

This prospective, randomised, ex vivo study investigated the effects of manual double-spin centrifugation protocols on the cellular and growth factor composition of equine platelet-rich plasma (PRP). Blood from 20 healthy horses was evaluated in two phases. In Phase A (n = 10), n...

Design, Fabrication, and Evaluation of a Patient-Derived 3D-Printed Anthropomorphic Breast Phantom for Performance Evaluation of Dual-Energy Subtraction in Contrast-Enhanced Mammography

An anthropomorphic patient-derived 3D-printed breast phantom (4.8 cm compressed thickness, 12.2% volumetric breast density) was evaluated for image-quality assessment in contrast-enhanced mammography (CEM). It comprises four 1.2 cm plates printed via fused filament fabrication (P...

Invited perspectives: Towards usable compound event research

Abstract. Supporting stakeholders with science-based decision-making to mitigate and adapt to climate change impacts is a central mandate of the climate research community. In particular, mapping out scenario-dependent climate risk landscapes is one of the most pressing challenge...

Michael Harward: ox-leech and philomath in Restoration Ireland

This article considers two previously overlooked texts, both printed in Dublin during the reign of Charles II by an otherwise unknown Quaker author named Michael Harward, who had emigrated from rural England to Ireland in the 1650s. The first is an almanac for 1666, the only know...

Field Observations of Tidal- and Thermal-Induced Deformations and Anchor Forces in Quay Walls

Abstract This case study investigates the mechanical and thermal response of anchored quay walls in the Port of Rotterdam through continuous field monitoring. Three structurally distinct combined quay walls, consisting of steel tubular piles with intermediate sheet piles, were ex...

Estimating the impacts of organic manures on grass yield, soil carbon storage and N2O emissions using the DNDC model and the impact of future climate change scenarios

Livestock manure management plays a critical role in sustaining agricultural productivity, in the absence of no or a limited supply of inorganic fertilizers, while also enhancing soil organic carbon (SOC) storage. Yet, its effects on greenhouse gas (GHG) emissions remain uncertai...

Genomic insights into the persistence of Nubian giraffe (Giraffa camelopardalis camelopardalis) in conflict-affected South Sudan

Abstract Armed conflicts can severely disrupt wildlife conservation and management, yet their long-term genomic consequences remain poorly understood. South Sudan has experienced decades of conflict that have limited conservation efforts and prevented genomic assessment of its fa...

The genome sequence of Dermanura phaeotis (Chiroptera, Phyllostomidae, Stenodermatinae; Miller, 1902)

We present a genome assembly from an individual male Dermanura phaeotis (Chordata; Mammalia; Chiroptera; Phyllostomidae). The genome sequence is 2.2 Gb in span. The majority of the assembly is scaffolded into 30 chromosomal pseudomolecules, with the X and Y sex chromosomes assemb...