Université Fédérale de Toulouse Midi-Pyrénées

Vegetative Barrier Acts as a ‘Trapper’ Rather than a ‘Filter’ for Potentially Toxic Element Contaminated Wind-Erodible Particles at the Vicinity of an Industrial Brownfield: Evaluation of a Nature-Based Solution

Brownfields can represent sources of multiple contaminants and may present health risks through airborne particle dispersion and incidental soil ingestion for surrounding populations. Remediation with nature-based solutions to mitigate legacy industrial pollution is therefore a r...

Evaluating Selection Strategies Based on Inbreeding Load via Simulation

Inbreeding load is the fraction of the mutation load that is due to recessive action of mutations. This load is only expressed in individual's inbred offspring. As such, inbreeding load contributes to genetic heterogeneity among individuals and can thus be used as a criterion of...

Surgical Morbidity and Short-Term Oncologic Status after Prophylactic-Intent Thyroidectomy in a Cohort of Children with MEN2 from the Multicenter GTE ENDOCAN-RENATEN Study

BACKGROUND: Children carrying germline RET mutations associated with multiple endocrine neoplasia type 2 (MEN2) are at high risk of developing medullary thyroid carcinoma (MTC). Prophylactic-intent thyroidectomy is recommended during childhood to prevent progression to advanced d...

Scalable Synthesisof a Masked Thiophenol as an Air-Stable,Odorless Intermediate to the Aurora Kinase Inhibitor Tozasertib (VX-680)

Abstract The use of thiophenols on process scales is fraught with challenges relating to their toxicity, malodor, and air sensitivity. We previously demonstrated that the Ni-catalyzed C–S coupling of aryl iodides and thiourea provides a discovery-scale route to S-aryl isothiouron...

DNTTIP2 coordinates RNA exosome activities to ensure fidelity of human ribosome assembly

Abstract The RNA exosome-associated helicase Mtr4/MTR4 (yeast/human) is recruited by adaptor proteins bearing Arch-Interacting Motifs (AIMs) to selectively degrade RNA substrates. Although the exosome targets diverse RNAs, only a few adaptors have been identified. Here, we extend...

STABILOOP, a cohort trial to assess automated insulin delivery in the management of patients living with type 1 diabetes who are eligible for islet transplantation

A limited subset of people living with type 1 diabetes (T1D) is affected by extreme glycemic lability and frequent unpredictable severe hypoglycemia, significantly impairing quality of life and associated with higher morbidity, mortality, and healthcare costs. Islet transplantati...

One‐Year Transcutaneous Tibial Nerve Stimulation Treatment Persistence in Lower Urinary Tract Dysfunction: Clinical and Urodynamic Associated Factors in a Prospective Observational Study

AIMS: To assess 1-year Transcutaneous Tibial Nerve Stimulation (TTNS) treatment persistence in routine clinical care and to explore clinical and urodynamic factors associated with treatment persistence in patients with lower urinary tract dysfunction (LUTD). METHODS: A prospectiv...

UnlockingSimple Hydroboranes for Selective C–HBorylation of (Hetero)arenes

Abstract Control of borane speciation through Me2PhN·BH3 formation enables HBcat-mediated, metal-free C–H borylation of (hetero)arenes via an electrophilic aromatic substitution pathway. The process operates without external catalysts or additives and provides a sustainable platf...