Université de Rouen Normandie

General heat release rate surrogates for NH3/H2/N2 and H2 flames using Raman/Rayleigh/LIF accessible species

Accurate estimation of the heat-release rate (HRR) is essential for understanding and controlling ammonia–hydrogen combustion, yet conventional experimental surrogates are strongly dependent on operating conditions and typically rely on radicals measured by laser-induced fluoresc...

The NPIS model: a consensus-based framework for evaluating non-pharmacological interventions

The term non-pharmacological intervention (NPI) refers to health prevention and care protocols supervised by healthcare professionals. However, no precise and widely adopted definition currently exists. Additionally, unlike drugs, NPIs do not have a global evaluation framework be...

A single-cell atlas of large B cell lymphomas reveals distinct malignant archetypes predictive of clinical outcomes

Large B cell lymphomas (LBCLs) exhibit significant heterogeneity which leads to disparate treatment response, with up to 40% of patients developing refractory disease or relapsing within the first two years. To understand the cellular and molecular basis of this heterogeneity, we...

Identification of a Point Source in the Heat Equation from Sparse Boundary Measurements

Abstract. In this work we investigate the inverse problem of recovering one point source in the heat equation from sparse boundary measurement, i.e., the flux data at several points on the boundary. We prove the unique recovery of the location and piecewise constant in time ampli...

In-host adaptation of Staphylococcus aureus during recurrent prosthetic joint infections: a retrospective longitudinal study

ABSTRACT The aim of this study was to characterize the in vivo evolution of Staphylococcus aureus strains involved in recurrent prosthetic joint infections (PJIs) both phenotypically and genomically. We conducted a monocentric retrospective study in a 1,437-bed French teaching ho...

On the role of error metrics in the assessment of chemical kinetic mechanisms

Methods intended to decrease the computational cost of chemistry, such as mechanism reduction, neural-network surrogates, or genetic optimization, rely on metrics to assess agreement with reference datasets. However, the role of error definitions in the design of these metrics re...

Aliphatic Diazirines Synthesis Mediated by Mild N -Chlorosuccinimide Oxidation

Abstract Diazirines have been known for decades as effective photoreactive moieties, with valuable applications in chemoproteomics. In recent years, they have received increasing interest in synthetic chemistry. Until recently, their access required a multistep process, which may...

Impact of ATP8B1 Mutation and Maturation on CFTR Functionality and Gene Expression

Background/Objectives: Progressive familial intrahepatic cholestasis type 1 (PFIC1) is a rare autosomal recessive liver disorder caused by mutations in the ATP8B1 gene, leading to defective bile acid secretion and severe clinical outcomes. A milder, episodic form of the disease,...

Oxidative Fluorination of β-Ketoamides: Guanidinium Iodides as Iodoarene Alternatives

Abstract A guanidinium iodide-catalyzed oxidative fluorination of β-ketoamides enables umpolung α-fluorination, replacing iodoarenes with a simple iodide source. Using HF·pyridine as the fluoride source and mCPBA as the oxidant in dichloroethane, quaternary α-fluoro-β-ketoamides...

Targeting Both Oncogenic Signaling and Dependence Receptor Function is Required to Fully Suppress MET Exon 14 Skipping-Driven tumorigenesis

Abstract Receptor tyrosine kinases (RTKs) classically function as oncogenic drivers that promote survival and proliferation upon ligand binding. A subset of RTKs can also function as dependence receptors, inducing apoptosis in the absence of their ligands. Genetic alterations tha...

Mechanistic insights into Nrf2- and PARP1-mediated radioresistance of glioblastoma stem cells under photon, proton, and carbon ion irradiation: An in vitro study

Glioblastoma multiforme (GBM) exhibits strong resistance to radiotherapy, partly driven by glioblastoma stem-like cells (GSCs) with enhanced redox homeostasis and DNA repair capacity. This study evaluated whether targeting Nrf2-mediated antioxidant signaling and PARP1-dependent D...

From fluid loss to calcification: MRI and CT matrix features in cystic echinococcosis

Abstract Objective To characterize MRI matrix signal and CT calcification patterns across WHO-IWGE stages, compare them with lesion mimicking cystic echinococcosis (CE), and derive an MRI-based subclassification for inactive cysts. Materials and methods This retrospective multice...

Evaluation of Disease Severity Using CSF Biomarkers in Patients With Probable Cerebral Amyloid Angiopathy

Cerebral amyloid angiopathy (CAA) is currently diagnosed using MRI-based Boston criteria. However, imaging markers represent downstream consequences of vascular injury and may not fully reflect disease severity. CSF biomarkers, particularly β-amyloid 1–42 (Aβ42) and β-amyloid 1–4...

Safety and Performance of the Colovac Anastomosis Protection Device. A Pooled Analysis of Prospective Studies Compared With Diverting Loop Ileostomy (SAFE-2025)

Objective: To compare the safety and effectiveness of the Colovac Anastomosis Protection Device with standard diverting ostomy (DO) following low anterior resection (LAR) for rectal cancer. Summary Background Data: DO is standard of care (SOC) following LAR for rectal cancer but...

The Probiotic Strain Hafnia Alvei HA4597 and Its Protein Extract Selectively Activate Membrane Digestive Enzymes of Intestinal Cells in Mice

Oral supplementation of the Hafnia alvei (H. alvei) HA4597 probiotic strain has been shown to reduce appetite, body weight and fat content in overweight humans and obese mice. However, it remains unknown if H. alvei may also influence the gut digestive function. Thus, in the pres...

Explainable Machine Learning Model for Early Hospital Admission Prediction in the Emergency Department: A Retrospective Analysis

Early prediction of hospital admission at emergency department triage may support clinical decision-making, patient flow coordination, bed planning and resource allocation. However, external validation of admission prediction models remains limited, while missing-data handling, c...

Optimal sequential change-point detection for Markov models under probability criteria over short time intervals

In this paper, we study sequential change detection problems in the Bayesian framework under the probability delay risk according to which the detection goal is to minimize the probability that the detection delay will exceed some admissible delay level. To do this, we represent...

New mechanistic insights into the widely used LiPO2F2 additive enabled by ultra-high-resolution FTICR-MS

Understanding how electrolyte additives influence the formation and evolution of the solid electrolyte interphase (SEI) is essential for improving the durability of lithium‑ion batteries. In this work, we investigate the role of lithium difluorophosphate (LiPO2F2, LiDFP) in 1 M L...

Toward Climate-Responsive Ocean–Terrestrial Biorefineries: Integrating Algae and Agricultural Residues for Circular Bioeconomies

Abstract This paper evaluates climate-responsive biorefineries that integrate pelagic Sargassum with agricultural residues to advance circular bioeconomies. Building on scientific priorities emphasized at the 2025 One Ocean Science Congress and emerging policy directions from the...

PLCG2 downregulation impairs synaptic function and increases Alzheimer’s disease hallmarks in neuronal cultures

We developed a high-content screening to investigate how Alzheimer’s disease (AD) genetic risk factors may affect synaptic mechanisms in rat primary neuronal cultures. Of the target genes identified, we found that Plcg2 downregulation in mouse dentate gyrus neurons consistently d...