Université de Montréal

Natural Light Exposure as a Potential 7th Pillar of Lifestyle Medicine

A growing number of studies highlight the observed effects of natural light exposure on health and bodily functioning, as well as its added value for the performance of daily activities. Although natural light exposure is gaining increasing recognition as a determinant of health...

Modelling mineral dust emissions from proglacial valleys of the St. Elias Mountains, Canada

Abstract. Proglacial valleys of western Canada and Alaska demonstrate extensive historical and contemporary records of mineral dust emissions. These contributions remain unresolved by current dust emission modelling and unaccounted for in global emission estimates. We developed a...

ATAD2 is a novel regulator of myogenesis and autophagy in skeletal muscles

Abstract The nuclear protein ATAD2 (ATPase family AAA domain containing 2) is a known positive regulator of cell proliferation in various cancer types. The expression and functional roles of ATAD2 in skeletal muscle cells are unknown. In this study, we used transient and stable k...

Introduction: Indexing Persons

Abstract This article introduces the special issue, “Indexing Persons.” In this introduction, we distinguish persona- and person-indexing registers . While the former refers to speech registers that enact social types of personhood, the latter denotes registers whose indexical va...

Comparative genomic analysis reveals distinct population structure in Legionella anisa

Abstract Legionella anisa has been frequently isolated from engineered water systems; however, its population structure remains understudied compared to Legionella pneumophila. Here, we generated complete genome sequences for four L. anisa isolates recovered from a healthcare fac...

Colchicine for cardiovascular secondary prevention: evidence from recent trials and meta-analyses

PURPOSE OF REVIEW: Residual inflammatory risk remains an important driver of recurrent vascular events despite contemporary lipid-lowering and antithrombotic therapies. Low-dose colchicine is the first widely available anti-inflammatory therapy to be incorporated into contemporar...

Cross-sectional evaluation of anthropometric measures vs MRI-measured visceral and hepatic fat in a Canadian cohort

Abstract Context Accurate assessment of excess body fat and its cardiometabolic risk is essential in clinical and epidemiologic research. Body mass index (BMI), although widely used, does not capture visceral or ectopic fat. Objective To evaluate how anthropometric measures—BMI,...

Reflex seizures and epilepsy surgery: A network approach case‐based exploration

Abstract Context Reflex seizures (RS) are defined by their consistent provocation by specific stimuli, encompassing a broad range from elementary sensory inputs to complex cognitive tasks. While RS are often encountered in clinical practice, their surgical management remains spar...

Learning German Language & Culture

We start studying german language & culture. The Carreer opportunities are great.

The Art of Printing [3D Engineering & Advanced Geometry]

There are sequences of actions that we repeat everyday. Among them is the printing action: print a numeric paper in pdf format and save it on your computer, or print it using a Xerox Machine or HP-printer. We found out we can do More: Let us Print in 3D Dimension, and investigate...

Storytelling as a public health competency: a call for training that responds to contemporary challenges

Public health has long emphasized letting quantitative data “tell the story”. Large, representative datasets allow researchers to answer questions about disease occurrence, risk, and interventions with rigor and precision. Yet, for many small, heterogeneous, historically-neglecte...

Lack of Efficacy of Low‐Dose Cyclobenzaprine on Electromyographic Activity Related to Sleep Bruxism: A Randomized Crossover Double‐Blind Placebo‐Controlled Clinical Trial

Sleep bruxism (SB) is a motor activity characterized by repetitive masticatory muscle contractions during sleep, commonly associated with tooth damage and jaw pain or headache. Pharmacological management strategies targeting its central nervous system-related mechanisms remain li...

The structure of the dopamine D 3 receptor bound to cariprazine reveals principles for partial agonists with designed pharmacology

The third-generation antipsychotic cariprazine is a low-efficacy partial agonist of the dopamine D 3 receptor (D 3 R). Here, we report the cryo–electron microscopy structure of cariprazine bound to D 3 R, establishing a framework for understanding ligand recognition in this recep...

Tissue-specific trace element accumulation, mercury and arsenic speciation in Atlantic walrus (Odobenus rosmarus rosmarus)

Walruses ( Odobenus rosmarus ) are long-lived Arctic marine mammals and play an important ecological and cultural role in northern communities. We quantified and compared concentrations of 34 elements in blubber, liver, and muscle tissues from 97 Atlantic walruses ( Odobenus r. r...

Conditioned Pain Modulation and Pleasant Pain Relief as Complementary Processes Reflecting Individual Differences in Pain Coping: A Clustering Approach

BACKGROUND: Pain perception is the result of different modulatory mechanisms. Inhibition, via descending brainstem mechanisms, is key to pain reduction and is typically elicited by the cold pressor test (CPT). Recently, a compensatory hedonic response has been observed after CPT...

Computationally Mediated Synthetic Affect as a Mechanism for Literacy Engagement: Analyzing Adolescents' Livestreamed Videogame Play

ABSTRACT The most affectively powerful narrative texts adolescents encounter are often videogames, yet literacy research has only begun to examine the feelings games produce and what they do for engagement. Extending Robinson and Leander's concept of synthetic affect—feelings co‐...

Pharmacokinetics of phosphodiesterase type 5 inhibitors and β-adrenergic receptor type 3 agonists for benign prostatic hyperplasia

Introduction Benign prostatic hyperplasia (BPH) is amongst the most common conditions affecting aging men, with resulting lower urinary tract symptoms (LUTS) impeding on quality of life. While many medication classes exist for treatment of LUTS secondary to BPH, their increasing...

Protein–protein interaction network architecture of human polygenic traits reveals domain-spanning connectivity and evolutionary pressures

Abstract Background Human polygenic phenotypes arise from the combined effects of many genes that interact within molecular networks. Yet, we know little about how the structure of these networks constrains or facilitates the evolution of complex traits. Here, we systematically e...

Does Order Matter? The Impact of Methodological Decisions in Survey Research Concurrently Examining Attachment to Mothers and Fathers

ABSTRACT While questionnaires are often validated in a context where participants respond to a questionnaire only once, it is common to complete a given questionnaire multiple times referring to different relationships in interpersonal relationship research. For instance, in atta...

Crystalline/amorphous silicon and silica Bragg reflectors for gravitational wave detectors

Coating thermal noise is a major source of noise in gravitational wave detection. In order to reduce this noise, we investigate the use of silicon-on-insulator (SOI) wafers as Bragg reflectors. First, we show different architectures, such as multi-SOI as top and bottom layers, in...