Université de Bordeaux

Initial treatment strategies and outcomes across haemodynamic thresholds and risk stratification in incident systemic sclerosis–associated pulmonary arterial hypertension: a EUSTAR analysis

OBJECTIVE: Real-world initial treatment strategies in SSc-PAH remain incompletely described. We aimed to characterise these strategies across haemodynamic thresholds and risk strata and evaluate outcome associations. METHODS: We analysed treatment-naïve SSc-PAH patients in EUSTAR...

DaiSy: A Library for Scalable Data Series Similarity Search

Exact similarity search over large collections of data series is a fundamental operation in modern applications, yet existing solutions are often fragmented, specialized, or tailored to specific execution environments. In this paper, we present DaiSy, a unified library for exact...

Double periodicity of the AnkyrinG-associated complex in the axon initial segment

The axon initial segment (AIS), situated within the first 20 to 60 µm of the axon, is essential for action potential generation and maintenance of axonal identity [M. N. Rasband, Nat. Rev. Neurosci. 11 , 552–562 (2010)]. Its structure relies on the beta (β)-IV-spectrin/AnkyrinG (...

Multiplex species-specific real-time PCR assays for the detection of European Armillaria spp. and Desarmillaria spp. in different environmental substrates

Armillaria root rot, caused by basidiomycete fungi of the genera Armillaria and Desarmillaria , affects numerous agronomic crops and forest trees worldwide. In Europe, seven species have been described, namely Armillaria mellea , A. ostoyae , A. gallica , A. borealis , A. cepisti...

Widespread hybridization in sympatric populations of allis shad Alosa alosa (L.1758) and twaite shad Alosa fallax (Lacépède 1803): A transnational perspective for conservation and management

Abstract The dynamics of hybridization between co‐occurring species in environments that have been modified by anthropogenic activities are important for generating new understandings of how species respond to disturbance and to support conservation management. Accordingly, the p...

Multiscale Method for Estimating the Thermal Properties of Sandwich Materials Using Infrared Thermography

Characterizing the thermal properties of sandwich materials remains complex because it demands a method that can independently analyze both the thin and thick layers within the same sample. We propose combining flash and step thermography methods with analytical modeling based on...

Antarctic sea ice over the past 130 000 years – Part 2: A review of its role in the Earth system

Abstract. Antarctic sea-ice cover reached historically low levels in 2023, consistent with the simulated decrease in sea-ice extent in response to anthropogenic warming. Antarctic sea ice is closely linked to multiple components of the Earth system, thus its demise could precipit...

Self-assembled nucleolipid G-quadruplexes act as multitarget decoys for oncogene suppression in pancreatic cancer

Abstract KRAS mutations drive multiple cancers and represent an important therapeutic target, together with other oncogenic regulators such as MYC , KIT , and BCL2 that are critically involved in pancreatic cancer. Here we describe a novel therapeutic strategy based on stable nuc...

Evaluation of Oral Health in Early Stages of Chronic Kidney Disease

Background/Objectives: Oral health may be affected by chronic kidney disease (CKD) through mechanisms including uremic toxin accumulation, immune dysregulation, and treatment-related factors, although these relationships remain poorly understood. This study aimed to describe oral...

Impact of Fluorine Content on Structure, Redox, and Electrochemical Performance of Disordered Rock-Salt Li1.25Mn0.5+ y /2Nb0.25– y /2O2– y F y Electrode Materials

Abstract Disordered rocksalt (DRS) oxides are highly promising positive electrode materials for next-generation Li-ion batteries, yet their practical application is severely bottlenecked by the irreversibility of oxygen-redox processes. Fluorination (O2– by F– substitution) repre...

Cutaneous Lymphoma International Prognostic Index and Risk Stratification in Advanced Mycosis Fungoides and Sézary Syndrome

Importance Risk stratification in advanced mycosis fungoides and Sézary syndrome (MF/SS) remains suboptimal given that current TNMB (tumor, node, metastasis, blood) staging has limited prognostic value for clinically relevant outcomes. Objective To determine whether the Cutaneous...

Cooperation in binary mixtures of active colloids

The complex interactions underlying collective motion in biological systems give rise to emergent behaviors such as flocking, sorting, and cooperative transport. These dynamics often involve species with different motilities coordinating movement to optimize navigation and surviv...

Quantum Graph Theory by Example

Quantum graphs have been introduced by Duan, Severini, and Winter to describe the zero-error behaviour of quantum channels. Since then, quantum graph theory has become a field of study in its own right. A substantial source of difficulty in working with quantum graphs compared to...

Faithful Universal Graphs for Minor-Closed Classes

Abstract. It was proved by Huynh et al. [ Universality in Minor-Closed Graph Classes, preprint, arXiv:2109.00327, 2021] that any countable graph containing every countable planar graph as a subgraph has an infinite clique minor. We prove a finite, quantitative version of this res...

Rapid estimation of structural brain disconnection from binary lesion masks using DeepDisco

Abstract Mapping how focal brain lesions disrupt structural connectivity is key to understanding cognition, behavior, and neurological outcomes. However, traditional diffusion tractography pipelines are computationally intensive, require specialized data and expertise, and remain...

Wild-type and mutated ß-catenin differently repress RND3/RHOE expression in hepatocellular carcinoma

Tumor development and progression are mainly driven by oncogenic mutations but are also regulated by physical factors. Through its structural and transcriptional functions, ß-catenin is a key factor that acts on both aspects to promote liver tumorigenesis, leading to hepatocellul...

The Sound and the Break: The Recoil of Immersion in 'Twelfth Night'

International audience

Intra- and inter-specific variability in benthic foraminifera modulates surface sediment reworking

Abstract Bioturbation is a key ecological process that regulates benthic ecosystem functioning, including organic matter remineralization and nutrient regeneration. Despite growing evidence that meiofauna, and benthic foraminifera in particular, contribute to sediment bioturbatio...

Immune‐related adverse events with mogamulizumab in cutaneous T‐cell lymphoma: A multicentre study

BACKGROUND: Mogamulizumab, an anti-CCR4 monoclonal antibody used in advanced mycosis fungoides (MF) and Sezary syndrome (SS), also depletes regulatory T cells, potentially leading to immune-related adverse events (irAEs). Unlike mogamulizumab-associated rash (MAR), other irAEs re...

Microbial metabolite p-cresol associates with constipation in adults with high-functioning autism spectrum disorder and induces constipation-like symptoms in mice

Abstract Gastrointestinal (GI) symptoms are prevalent in Autism Spectrum Disorder (ASD), yet their biological correlates remain poorly understood, notably in adults. The microbiota-derived metabolite p- cresol is reported to be elevated in the urine and stool of ASD patients, but...