Universitätsmedizin Göttingen

Nicotinamide Riboside for Patients With Early-Stage Parkinson Disease

Importance Nicotinamide riboside, a nicotinamide adenine dinucleotide precursor, has been proposed as a potential disease-modifying therapy for Parkinson disease based on preclinical and early studies. Whether prolonged oral nicotinamide riboside improves clinical outcomes in Par...

FIND: a phase-II study to evaluate the efficacy and safety of erdafitinib in FGFR-altered NSCLC

Abstract Introduction: FGFR alterations occur in approximately 2% of non-small cell lung cancer (NSCLC) patients, predominantly in squamous cell histology (sqNSCLC). We evaluated the efficacy of the selective FGFR1-4 inhibitor erdafitinib in patients with FGFR-altered NSCLC. Meth...

Using multi-trait polygenic scores to predict lithium responsiveness in patients with bipolar disorder

Background The predictive power of polygenic scores (PGSs) for lithium treatment response in bipolar disorder remains limited. Aims To enhance the prediction of lithium responsiveness by developing a multi-trait PGS (mt-PGS) combining genetic information from multiple phenotypes...

Cutaneous Lymphoma International Prognostic Index and Risk Stratification in Advanced Mycosis Fungoides and Sézary Syndrome

Importance Risk stratification in advanced mycosis fungoides and Sézary syndrome (MF/SS) remains suboptimal given that current TNMB (tumor, node, metastasis, blood) staging has limited prognostic value for clinically relevant outcomes. Objective To determine whether the Cutaneous...

Feasibility, acceptability, and preliminary estimates of a multimodal AKTIVER Heart Delirium Prevention Program in patients indicated for cardiac surgery: study protocol of a randomized controlled PREVENT POstoperative Delirium (PREVENT-POD) Pilot Study

Abstract Background Postoperative delirium (POD) is a common complication in geriatric patients undergoing cardiac surgery. POD is associated with prolonged length of stay in the intensive care unit and hospital, increased mortality, institutionalization, distress, risk of cognit...

Clinical management of metachromatic leukodystrophy cases identified in the German and Austrian Newborn screening pilots

Abstract Background Metachromatic leukodystrophy (MLD) is a rapidly progressive leukodystrophy that leads to severe disability and early death if untreated. Autologous hematopoietic stem and progenitor cell gene therapy (HSPC-GT, atidarsagene autotemcel, arsa-cel) for early onset...

PPM1H loss alters intrasynaptic alpha-synuclein localization in a LRRK2-dependent manner

Abstract Mutations in the LRRK2 gene are a major genetic cause of Parkinson’s disease (PD) and induce hyperphosphorylation of RAB GTPases through increased LRRK2 kinase activity. The phosphatase PPM1H counteracts this activity by selectively dephosphorylating LRRK2-phosphorylated...

MRI-derived prostate volume assessment: manual segmentation versus two-axis ellipsoid approximation and its implications for PSA density

Abstract Purpose To evaluate how accurately prostate volume estimated with the ellipsoid formula matches manual segmentation (reference standard) and to assess whether an individualized, volume-dependent adjustment of the ellipsoid weighting factor improves performance. Methods I...

Accelerated erosion of the Eastern European Alps since ~ 3 Ma: a response to climatic cooling?

Global cooling and repeated glaciations during the late Cenozoic are inferred to have altered the topography of many mountain belts by enhancing the rates of erosion and valley incision. However, quantifying these changes in erosion rate and local relief has proven challenging. I...

Lysosomal signaling pathways influence heart rhythm, and regulate atrial function

AIMS: In the heart, endogenous nicotinic acid adenine dinucleotide phosphate (NAADP) triggers lysosomal calcium (Ca2+) release to augment sarcoplasmic reticulum (SR) Ca2+ sequestration, producing larger Ca2+ transients. However, the role of lysosomal Ca2+ signals in pacemaker act...

Deciphering the genomic signatures of climate vulnerability across 77 sheep breeds

Abstract Among domesticated species, sheep ( Ovis aries ) have achieved a wide geographic distribution due to their mobility, rusticity and ability to adapt to diverse environments and climatic conditions. Here, we characterise the genome-wide diversity of >1,000 sheep representi...

Real-time monitoring of CAR T cell dynamics in tumor patient-derived organoids using the OrganoIDNet algorithm

Abstract Background Patient-derived organoids (PDOs) provide physiologically relevant 3D tumor models for preclinical drug testing, yet robust and automated methods to quantify dynamic responses to immunotherapies remain limited. OrganoIDNet is a deep learning-based image analysi...

Modelling eCPR eligibility after out-of-hospital cardiac arrest: a 10-year retrospective temporospatial analysis from a mixed urban-rural region in Germany

Abstract Background Survival with good neurological function after out-of-hospital cardiac arrest (OHCA) remains low. Extracorporeal cardiopulmonary resuscitation (eCPR) may benefit selected patients, but it is unclear how many patients in a mixed urban-rural European region woul...

Region-specific QCT thresholds for osteoporosis assessment in the thoracic spine: why lumbar cut-offs fail

Abstract Background Quantitative computed tomography (QCT) is increasingly used for preoperative bone quality assessment in spine surgery. However, established QCT osteoporosis thresholds are based on lumbar reference regions and are frequently extrapolated to the thoracic spine,...

Positive selection of IgG over IgM plasma cells through BCR isotype–specific antigen presentation and signaling

During a primary immune response, B cells can undergo isotype switching from an immunoglobulin M (IgM) B cell receptor (BCR) to an IgG BCR. B cells that have switched to IgG give rise to more bone marrow long-lived plasma cells (PCs) compared with those expressing IgM, but how BC...

Nanobodies Equipped with HaloTag Enable Scalable Fluorescence-Lifetime Multiplexing

Abstract Fluorescence lifetime (FL) is a robust strategy for multiplexed imaging; however, variability in fluorophores’ local microenvironment when used on affinity probes broadens lifetime distributions, limiting its practical applicability. We create a modular platform for FL e...

Dual effect of α-synuclein disease variants on condensate formation

Abstract α-synuclein is a pre-synaptic protein implicated in synucleinopathies including Parkinson’s disease, Parkinson’s disease dementia, and dementia with Lewy bodies, where it accumulates in intracellular aggregates termed Lewy bodies and Lewy neurites. Recent studies have re...

Superlarge-Bore Versus Large-Bore Aspiration Catheters in Mechanical Thrombectomy: A Multicenter Propensity-Matched Analysis

BACKGROUND AND OBJECTIVES: Aspiration catheters are an integral component of mechanical thrombectomy for acute ischemic stroke (AIS). Following early series demonstrating increasing procedural efficiency and improved outcomes with use of large-bore (LB) aspiration catheters, ther...

9.4‐Tesla magnetic resonance imaging in focal epilepsy patients with high‐resolution surface‐based profiling of focal cortical dysplasias

Abstract Objective The detection of subtle epileptogenic lesions such as focal cortical dysplasias (FCDs) is a clinical challenge in the management of drug‐resistant focal epilepsy (DRFE). Ultra‐high‐field (UHF) magnetic resonance imaging (MRI) offers increased signal‐to‐noise ra...

Change in COVID-19 outcomes in lymphoma patients across pandemic waves: results of the COVID-19-lymphoma registry of the Bavarian Cancer Research Center (BZKF) 2020–2022

Abstract Patients with malignant lymphomas are at increased risk for severe COVID-19. In the general population, outcomes of COVID-19 have improved dramatically over time due to increasing immunity through vaccination or infection and due to improved clinical care. It is unclear...