Universitat Pompeu Fabra

First Sounds, Second Language: How Word Onsets Spark Language Co‐Activation in 3‐Year‐Old Bilinguals

ABSTRACT Adult and young bilinguals co‐activate their languages to different degrees, even in entirely monolingual tasks. However, many studies use translation pairs with high phonological overlap (e.g., the English‐GERMAN: “milk”‐“MILCH”), making it difficult to discern the orig...

Neurobiological correlates of longitudinal grey matter volume changes in preclinical Alzheimer’s disease

Background: Structural brain changes during the earliest asymptomatic stages of Alzheimer's disease (AD) remain poorly understood. Previous research in preclinical AD shows heterogeneous findings, reporting both subtle neuronal loss and paradoxical increases in grey matter (GM) v...

A serotonergic mechanism is involved in the pro-cognitive effect of AM6545 treatment in a mouse model of fragile X syndrome

Abstract Fragile X syndrome (FXS) is the principal monogenic syndrome leading to inherited intellectual disability and autism. It is caused by the silencing of FMR1 gene that leads to the loss in the expression of its encoded protein, the fragile X messenger ribonucleoprotein 1 (...

Insights into interaction management through backchannels

Abstract This paper analyzes backchannel signals in two signed languages: French Belgian Sign Language (LSFB) and Catalan Sign Language (LSC). While backchannels have been extensively studied in spoken languages, their documentation across signed languages remains sparse in compa...

Ciliogenic pancreatopathy reveals a link between ciliopathies and exocrine pancreatic disease

Abstract Background While pancreatic cysts have been described in syndromic ciliopathies, the pancreas is not commonly recognized as a target organ. However, several ciliary gene knockout mouse models develop a pancreatic phenotype combining acinar atrophy and adipocyte accumulat...

Quality of guidelines for the management and prevention of occupational risks during pregnancy: a systematic quality assessment using the Appraisal of Guidelines for Research and Evaluation (AGREE II)

OBJECTIVE: This review aimed to appraise the quality of existing guidelines on the management of occupational risks for employed women during pregnancy, identifying and describing their characteristics. METHODS: We systematically identified guidelines in MEDLINE, Embase, CINAHL,...

Synthetic horizontal gene transfer for ecosystem restoration

Abstract Restoring endangered ecosystems has become a pressing issue as the effects of global warming continue to harm existing communities. During the last decade, several studies have suggested the use of synthetic biology as a tool to protect these biodiverse communities by in...

Adaptive oncogenesis of β-catenin emerges from declining liver tissue integrity

Abstract Mutations are fundamental to oncogenesis, yet they cannot fully explain cancer progression, as oncogenic mutations frequently accumulate in healthy tissues without immediate malignancy. In the liver, β-catenin mutations are highly prevalent in hepatocellular carcinoma bu...

The sweet spot in protein design—Where deep learning meets first principles

This Perspective explores recent methods and prospective ideas for developing hybrid AI-physics-based pipelines for protein and antibody de novo design. We argue that the highest-confidence candidates emerge where deep learning and first-principles models agree, a "sweet spot" th...

Improving Function-Hiding Functional Commitments

Function-hiding functional commitment schemes allow one party to commit to a private function f and later prove f(x)=y for public x and y without revealing additional information about the function. We construct efficient function-hiding functional commitment schemes for arithmet...

The 6‐Form Model of Re/Integration: From Prison to Community

ABSTRACT In spite of a substantial rise in academic, policy and research interest in life after prison worldwide, people often face acute, compounded and permanent adversities on release. Despite this growing interest, our knowledge on re/integration and life after prison remains...

The first 72 hours of acute pancreatitis: patterns of variability in early clinical decision-making

To assess real-world adherence to evidence-based international guidelines in the early management of acute pancreatitis (AP), and to identify how variability in clinical decision-making is distributed during the first 72 h of care. This multicentre, cross-sectional survey was con...

Efficacy, Effectiveness, and Efficiency of Nurse‐Led Interventions: Insights From a Critical Systematic Review

Healthcare systems worldwide face mounting pressure to deliver high-quality care while enhancing efficiency and sustainability. Nurse-led interventions have emerged as promising strategies to optimize care delivery, particularly within value-based health systems. However, a compr...