Universitat de València

BioFRAM PGx, an Implementation Proposal for Pharmacogenetics in the Spanish National Health System

Background/Objectives: Pharmacogenetics (PGx) may improve drug safety and effectiveness, but its integration into routine care remains heterogeneous across the Spanish National Health System (NHS). This article presents BioFRAM PGx, a multicentre implementation framework that def...

Resilience behaviors as mechanisms for scaling impact in social enterprises

Purpose This study examines how social enterprises build organizational resilience during scaling processes, extending the Nonprofit Resiliency Framework beyond crisis contexts to scaling scenarios. Design/methodology/approach Qualitative research based on 21 in-depth interviews...

Constraints on Large-Scale White Noise in the Cosmic Density Field

We present observational constraints on large-scale white noise (LSWN) in the cosmic density field, a phenomenon predicted to arise from nonlinear mode coupling during cosmological evolution. Building on the theoretical framework of our companion paper, where we demonstrated that...

Transposed-letter effects as a function of the location of transpositions

We examined how Transposed-Letter effects (TL effects: e.g., ASBENT, derived from ABSENT, compared to the substituted-letter [SL] control ALPENT) might vary as a function of the location of the TL effects relative to fixation. The positions of the TL and the initial fixation loca...

Incidence, prevalence, and ketoacidosis at onset of type 1 diabetes in Spain: a systematic review and critical assessment of the available evidence

The incidence, prevalence and onset of type 1 diabetes (T1D) with diabetic ketoacidosis (DKA) in Spain remain insufficiently characterized, despite multiple regional analyses. This study aims to summarize and critically assess epidemiologic data in Spain, incorporating insights f...

From measurement to reasoning: a formative assessment framework for data visualisation literacy in data-intensive learning environments

Purpose Data visualisation literacy (DVL) is increasingly recognised as a key component of data and information literacy in data-intensive learning environments. Existing assessment instruments such as the Visualisation Literacy Assessment Test (VLAT) and Mini-VLAT provide reliab...

GRB 260310A / SN 2026fgk: A Multi-Wavelength Study of a Nearby Underluminous Long GRB and SN with a Complex Afterglow

Abstract We present a comprehensive multi-wavelength study of GRB 260310A / SN 2026fgk, a nearby (z = 0.153), long-duration gamma-ray burst (GRB) with an exceptionally underluminous prompt γ-ray emission and a Comptonized spectrum. The burst occurred at the edge of a blue host ga...

Wheel Diameter Affects Vibration Transmission but Not Performance During Uphill and Downhill Mountain Biking over Rough Terrain

Mountain biking over rough terrain exposes riders to vibrations that may affect comfort, health, bicycle control, and performance. This study analyzed the effect of wheel diameter on vibration transmission and performance during a short uphill and downhill test over rocky terrain...

Rushing to the altar? Same-sex marriages when rights feel at risk

Abstract The literature on same-sex marriage has primarily focused on the effects of legal recognition, overlooking other factors that influence marriage decisions among same-sex couples. This study provides novel evidence on the role of political context by analyzing how the ele...

Effects of Zinc Supplementation on Glycemic Control, Insulin Resistance, Inflammation and Oxidative Stress in Diabetes: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials

ABSTRACT Objectives Diabetes mellitus (DM) is a chronic metabolic disorder characterized by insulin resistance, impaired insulin secretion, and increased cardiometabolic and inflammatory burden. Zinc plays a key biological role in insulin synthesis, storage, signalling and antiox...

Integrated multiomics analysis reveals metabolic and microbiome alterations in Wilson disease

Wilson disease (WD) is a rare autosomal recessive disorder caused by mutations in ATP7B , which encodes a copper transporter. Abnormal ATP7B function leads to copper deposition, mainly in the liver and brain, resulting in hepatic, neurological, and psychiatric impairments. Metabo...

Institutional determinants of ISSA 5000 readiness in Latin American universities: evidence from a multinomial logistic model

Purpose This study identifies the institutional factors that condition the probability of Latin American higher education institutions (HEIs) reaching different readiness levels for external sustainability assurance under ISSA 5000 the first international standard on sustainabili...

Availability and representativeness of freshwater macroinvertebrate data to enable Europe-wide assessment of biodiversity trends

Freshwater ecosystems, though covering less than 1% of Earth's surface, harbor around 10% of all species. Pressures like pollution, water extraction, and habitat loss can exhibit complex interactions in their effects on freshwater biodiversity. Understanding the effects of these...

Neural substrates of female sexual rejection: hypothalamic pathways to the periaqueductal gray

Abstract Selecting an appropriate behavioral response according to one’s internal state is essential for well-being. Across the reproductive cycle, fluctuating levels of sex hormones align female behavior with reproductive capacity by modulating neuronal circuits that express hor...

Ochratoxin A Toxicity Research in In Vitro and In Vivo Experimental Settings: A Cross-Software Bibliometric and Science-Mapping Study

Background: Ochratoxin A (OTA) is a widespread mycotoxin with well-established nephrotoxic, immunotoxic, and carcinogenic properties. Despite decades of research, the structure, thematic evolution, and emerging directions of the scientific literature on OTA toxicity remain incomp...

Managing sports with artificial intelligence: resistance and acceptance

Purpose This study aims to explore the determinants that shape the intentions of sports business managers to accept or object to the use of artificial intelligence (AI) within their organizations. This research addresses the gap in the management field regarding AI adoption in th...

The common good in business ethics: disentangling a crucial concept

Purpose This paper aims to examine how the notion of the common good has evolved within the social sciences, with a particular focus on its application in business ethics and corporate social responsibility. Although scholars often cite the concept, they frequently use it ambiguo...

Towards Situated Climate Education: Territorial Memory, Climate Justice and Emotional Literacy in Teacher Education (TEJA Model)

Climate change education has expanded in curricular, institutional and media arenas, yet it still faces a central challenge: turning scientific knowledge into educational practices that transform perceptions, decisions and participation. This article argues that the challenge can...

Characterization of Anisotropic Optical Behavior in Phase‐Change Material Sb 2 Se 3

ABSTRACT Phase‐change materials with ultralow optical losses are enabling a new generation of reconfigurable photonic devices. Sb 2 Se 3 has emerged as a leading candidate owing to its negligible optical losses across the visible and infrared, yet how polycrystallinity translates...

Power-Based Multicomponent Training, Pelvic Floor Muscle Activation Instructions, and Psychoeducation for Urinary Incontinence, Balance and Fear of Falling in Older Women (FIRE-WOMEN): Study Protocol for a Randomized Controlled Trial

Background/Objectives: Urinary incontinence (UI) and impaired balance are common geriatric syndromes that negatively affect health and quality of life in older women. However, the combined effects of power-based multicomponent training (PMT), pelvic floor muscle (PFM) activation...