Università della Svizzera italiana

From Structureto Dynamics: Activation Mechanism ofthe G Protein-Coupled Bile Acid Receptor 1-Gs Complex

Abstract The G protein-coupled bile acid receptor 1 (GPBAR1, also known as TGR5) is a key mediator of bile acid signaling, exerting its physiological effects through coupling with the stimulatory G protein (Gs). This interaction stabilizes the receptor’s active state and triggers...

Institutionalizing Transdisciplinarity in Higher Education: Strategic Areas and Reflexive Governance

This article proposes a practice-informed institutional design framework for embedding transdisciplinarity (TD) as an operational orientation in higher education. Building on the Reflexive and Situated Model for Institutionalizing Transdisciplinarity, the study examines how TD ca...

Corporate Corruption: A Scoping Review and a Dynamic Model of Its Antecedents

Abstract Corruption affects societies worldwide and takes diverse forms across both the public and private sectors. Existing research highlights the complexity of its antecedents and how they operate across macro, meso, and micro levels. However, while public-sector corruption dy...

When Institutions Are Not Enough: Bottleneck Dynamics in Evaluation Capacity Across the MENA Region

This study reconceptualizes evaluation capacity as a noncompensatory system in which specific dimensions function as binding constraints, addressing the puzzle that countries with similar formal capacity scores produce sharply divergent levels of evaluation use. Applying Necessar...

Serum Glial Fibrillary Acidic Protein Dynamics, Disease Progression, and Therapy Response in Multiple Sclerosis

Importance: Capturing individual multiple sclerosis (MS) progression is difficult; few studies have evaluated glial fibrillary acidic protein (GFAP) in large longitudinal cohorts with independent validation. Objective: To investigate whether serum GFAP levels and treatment-relate...