Universidade Federal do Triângulo Mineiro

Phytochemical Screening and Protective Effects of Hancornia speciosa Leaf Extract Against Fatty Acid-Induced Lipotoxicity in HepG2 Cells

Hepatic steatosis is the hallmark of metabolic dysfunction-associated steatotic liver disease (MASLD), the most prevalent chronic liver disease worldwide. Lipotoxicity, resulting from excessive accumulation of fatty acids and bioactive lipid intermediates, is associated with incr...

Is There Still a Place for the Use of Hydrogen Peroxide in Neurosurgery?

Abstract Hydrogen peroxide (H2O2) has been used in neurosurgery for over a century as a hemostatic and antimicrobial agent. Despite its long history, its role in modern neurosurgical practice remains controversial due to significant safety concerns. This review examines the chemi...

Amazonian forest residues as bioenergy resources: pyrolysis behavior, kinetic triplets and model validation

Wood residues from sustainable forest management in the Amazon represent an underexploited feedstock for thermochemical conversion, yet the pyrolysis kinetics of these materials remain poorly characterized. Eleven native Amazonian species were physicochemically characterized and...

Built for bulk: posture, microanatomy and soft tissue shaped gigantism in Sauropoda

Abstract Sauropodomorph dinosaurs show how appendicular skeletal architecture accommodated extreme increases in body mass. Although sauropod gigantism has been linked to columnar limbs, wide-gauge posture, thick articular cartilage and tubular long-bone organization, the biomecha...

Development of a model based on FMEA, AHP and 2-tuple fuzzy linguistic representation for supply risk assessment

Purpose This paper proposes a model based on analytic hierarchy process (AHP), 2-tuple fuzzy linguistic representation and failure mode and effect analysis (FMEA) to measure risks associated with suppliers of critical items. Design/methodology/approach In the proposed model, AHP...

Association of Native American, European, and African Ancestry with CYP450 Pharmacogenetics and Metabolic Phenotypes in Admixed Latin American Populations from Ecuador and Nicaragua

Background/Objectives: Interethnic variability significantly influences drug response, highlighting the importance of assessing genomic ancestry for personalized medicine. Although Latin American populations are highly admixed, they remain underrepresented in pharmacogenetic rese...

Micro- and Nanoplastics in the Human Exposome: Environmental Pathways, Kidney Toxicity, and Implications for Public Health Risk Assessment

Plastic pollution has emerged as a global environmental and public health crisis, with micro- and nanoplastics (MNPs) representing a pervasive component of the human exposome. Generated through the continuous fragmentation of larger plastic materials, MNPs exhibit physicochemical...

Low‐Dose Chlorothalonil Induces Testicular Injury Through Disruption of Steroidogenic Signaling in Adult Male Mice

ABSTRACT Chlorothalonil (CHL) is a widely used organochlorine fungicide frequently detected in environmental and food matrices. Although increasing evidence indicates adverse effects in nontarget species, the mechanisms underlying CHL‐induced male reproductive toxicity remain inc...

State-of-Art on Multidisciplinary Approaches to Meningioma: A Systematic Review of the Available Evidence

Background: Meningiomas are the most common primary intracranial tumors, often requiring complex management due to their proximity to critical neurovascular and orbital structures. While surgery remains the cornerstone of treatment, achieving optimal outcomes requires coordinated...