Universidade Estadual Paulista (Unesp)

Toxicological evidence that methylmercury exposure amplifies bone destruction and systemic impact associated with apical periodontitis in rats

Abstract This study investigated whether long-term methylmercury exposure aggravates apical periodontitis in Wistar rats. Thirty-two male rats (90 days old) were randomized into four groups (n = 8): control, methylmercury, apical periodontitis, and methylmercury + apical periodon...

Molecular investigation of coronavirus and Leptospira spp. in bats (Chiroptera, Mammalia) from Brazil

Abstract The emergence of zoonotic diseases highlights the need for continuous surveillance of wildlife, particularly bats, known as natural reservoirs of several pathogens. This study aimed to investigate the presence of coronaviruses (CoV) and Leptospira spp. in non-hematophago...

Mitogenomic and phylogenomic analyses identify a cohesive Western Atlantic lineage within the Narcine complex (Torpediniformes: Narcinidae)

Accurate species delimitation within electric rays of the genus Narcine has been hindered by overlapping morphological characters and limited molecular resolution in previous single-locus studies. This study aims to evaluate phylogenetic relationships and species boundaries withi...

Does donating human milk result in greater compromise to the bone mass of breastfeeding mothers?

OBJECTIVE: Although the effects of lactation on bone mass are frequently discussed, it is unknown whether these effects are intensified in breastfeeding mothers (BFM) who become donors (BFM-donors). Thus, the objective was to evaluate alterations in bone densitometry and bone met...

A divergent betacoronavirus with a functional furin cleavage site in South American bats

Abstract Bats are natural reservoirs for a wide range of RNA viruses. Members of the genus Betacoronavirus , including Severe Acute Respiratory Syndrome virus 2 (SARS-CoV-2) and Middle East Respiratory Syndrome virus (MERS-CoV), have attracted particular attention due to their re...

Self-medication and psychological symptoms among undergraduate health science students: exploratory associations with religiousness and spirituality in a cross-sectional study

Undergraduate health science students experience academic, clinical, and social demands that may affect psychological well-being and influence self-care practices, including self-medication. Religiousness and spirituality may be associated with how students experience and interpr...

Prevalence of Bartonella spp., Borrelia spp., and piroplasmid in HIV-infected symptomatic individuals in Brazil: a cross-sectional study

Abstract Background Bartonella spp., Borrelia spp., and piroplasmid are increasingly recognized as vector-borne pathogens worldwide, with documented circulation in arthropod vectors and animal reservoirs in Brazil. The purpose of this study was to assess whether Bartonella exposu...

Influence of antioxidant agents following intracoronal bleaching with different hydrogen peroxide concentrations on the adhesive interface and fracture resistance

Purpose To evaluate the influence of a 25% alpha-tocopherol antioxidant gel (AT) and a 50% DL-α-lipoic acid antioxidant solution (AL) on coronal fracture resistance and the integrity of the adhesive interface between coronal dentin and a universal adhesive system (Ambar Universal...

Synergistic Effects of pH and Temperature on Dengue Virus Envelope Dimers: Insights from Microsecond Molecular Dynamics Simulations

Abstract Dengue pathogenesis depends on a conformational rearrangement of the envelope glycoprotein (pE) induced by low pH. However, how pH and temperature cooperate to destabilize the dimeric form of the pE, a fundamental step that enables the formation of the fusion-active trim...

Anti-Inflammatory, Antioxidant, and Antimicrobial Potential of Natural Products

Natural products have historically represented an important source of bioactive molecules with applications in nutrition, health promotion, and disease management [...]

How Deep is Your DES? A Numerical Framework for Ideal Eutectic Prediction in Multicomponent Mixtures

Abstract Here, we present a simple and computationally efficient procedure to determine the eutectic temperatures of ideal binary, ternary, and higher-order mixtures, providing a quantitative reference for evaluating deep eutectic solvent (DES) behavior. In the DES literature, te...

The endurance of a political idea: the state among its peers

The current state of affairs in international politics can be described as one of rivalry. It can be surprising for someone who followed international politics in the last thirty years, because riv...

Seed morphological screening improves germination efficiency but poorly predicts selfing in Eucalyptus hybrids

Breeding strategies in commercial Eucalyptus plantations have largely relied on crosses among hybrid genotypes, resulting in the recurrent selection of a limited number of superior clones. In this context, the development of inbred lines represents a complementary approach to bro...

Time-reversal symmetric quadratic differential systems having an invariant cylinder: global dynamics and mechanical application

Abstract This paper provides a comprehensive analysis of the global dynamics and an exact mechanical application for a class of time-reversal symmetric quadratic differential systems in $$\mathbb {R}^{3}$$ R 3 having an elliptic cylinder as an invariant algebraic surface. A norma...

Microstructural Evolution and Morphological Aspects of Titanium Carbides in Weld-Deposited Coatings using Chip-Based Fluxes

Abstract This work examines how joint design–controlled dilution governs microstructural evolution and titanium carbide morphology in GTAW cladded hardfacing layers produced using recycled Ti6Al4V chips and graphite. Hardfacing coatings were deposited into V-groove geometries of...

Fast adsorption of Mn2+ and Zn2+ on commercial LTA zeolite: kinetics, equilibrium, and preliminary reuse assessment

Abstract Commercial LTA-type zeolite was evaluated for the adsorption of Mn 2+ and Zn 2+ from aqueous solutions, with emphasis on the relationship between framework properties and adsorption behavior. Despite its very low BET surface area, the zeolite showed rapid and highly effi...

Simultaneous Paranasal Augmentation and Le Fort I Osteotomy Using a Patient-Specific Implant Designed to Share the Fixation Space: Two-Year Clinical Outcomes

BACKGROUND: Residual paranasal concavity may persist after Le Fort I osteotomy despite adequate maxillary repositioning, limiting the aesthetic impact of orthognathic surgery. Simultaneous paranasal implant placement is rarely reported due to spatial conflict with rigid internal...

Wild felids as sentinels of antimicrobial resistance: susceptible Escherichia coli isolates from a protected area in southeastern Brazil

Abstract Antimicrobial resistance (AMR) is a major global health concern, and its monitoring in wildlife is essential from a One Health perspective. Here, we obtained bacterial isolates and assessed the AMR profiles and extended-spectrum β-lactamase (ESBL) production of Escherich...

Cladistics of the Zethus spinosus de Saussure Species Group: A New Subgenus of Zethus Fabricius, 1804 (Hymenoptera, Vespidae)

Zethus Fabricius is the largest genus of vespid wasps with over 300 species worldwide that are divided into subgenera and further into species groups. Recent phylogenetic studies raised the number of subgenera from four to nine, six of which are in the Neotropics. However, three...

Blending PCI Coal and Biochar as Sustainable Alternative for Blast Furnace Fuels

The aim of this study was to investigate the feasibility of using biochar or its blends with pulverized coal injection (PCI) coal as a potential blast furnace (BF) fuel. A comparison was conducted between the properties of biochar obtained from the pyrolysis of coconut shell and...