Universidad de Salamanca

Incidence, Causes, and Outcomes of Conversion to Open Surgery During Minimally Invasive Left Pancreatectomy: A Prospective Multicenter Study

ABSTRACT Background Minimally invasive left pancreatectomy (MILP) has become the preferred approach to treat lesions of the pancreatic body and tail. However, the procedure may require conversion to open surgery, with reported conversion rates varying widely in the literature. Th...

BioFRAM PGx, an Implementation Proposal for Pharmacogenetics in the Spanish National Health System

Background/Objectives: Pharmacogenetics (PGx) may improve drug safety and effectiveness, but its integration into routine care remains heterogeneous across the Spanish National Health System (NHS). This article presents BioFRAM PGx, a multicentre implementation framework that def...

A Social Work Perspective on Preparing for Retirement in Spain: Beyond the Economic Approach

Population aging and labor market transformations pose urgent challenges in Spain that require a critical review of retirement preparation from a social work perspective. This article analyses such preparation through a qualitative policy analysis and narrative literature review...

From Student Support to Transformative Education: Reinterpreting University Mentoring Through the Lens of Education for Sustainability

Mentoring is widely recognized as a strategy for supporting students’ academic and personal development, yet its role in the Education for Sustainability (EfS) remains poorly understood. Meanwhile, universities have expanded sustainability policies, governance structures, and cur...

From Structural Inequalities to Labor Precarity: Adoption of Digital and AI Tools in Latin American Journalism

While inequalities in technological access and use have been widely documented, few studies have examined their link to labor precarity and social inequality in journalism in the Global South. This article analyzes this relationship through a multilevel study of Worlds of Journal...

Machine learning-guided design of ORC working fluids for waste heat recovery

Identifying sustainable working fluid alternatives without compromising system performance is critical for advancing the deployment of Organic Rankine Cycle (ORC) technology in renewable energy systems. This study presents a novel computer-aided molecular and process design (CAMP...

Subchronic Cannabidiol (CBD) Treatment During the Silent Period Fails to Prevent Increased Seizure Susceptibility Following Lithium-Pilocarpine-Induced Status Epilepticus

Introduction. In recent years, cannabidiol (CBD) has been used as an adjunct therapy to anti-seizure medications for the control of seizures in patients with drug-resistant epilepsy. In addition to its anticonvulsant effect, CBD also has well-defined anti-inflammatory properties....

Nanotechnology-Enabled Remediation of Contaminated Soils: Mechanisms, Soil Constraints, Environmental Risks, and Implications for Sustainable Land Management

Engineered nanomaterials have been increasingly proposed for the treatment of contaminated soils. Nevertheless, most available evidence has been obtained in water, artificial substrates or short-term laboratory experiments, and performance in real soil is substantially more varia...

Gender Disparities in Sentencing: An Exploration of Differences in the Case Characteristics Defining a Criminal Case and Their Effect on Sentence Severity

Criminal justice system is not gender neutral. Female and male offenders are often differently treated. This research is aimed to study gender disparities in the construction of cases, the effect of gender in receiving an immediate custodial sentence and to explain whether dispar...

Planktonic foraminifera iodine ∕ calcium ratio: is it a proxy for dissolved oxygen in the ocean?

Abstract. Direct observations indicate a declining trend in ocean oxygen concentrations, which is not quantitatively captured by models. The complexity of oxygenation variability, linked to both physical and biochemical parameters, must be investigated across different modern cli...

Twin Transition Priorities Within the Sustainable Development Goals and Economic Freedom in the European Union: A Pillar‐Level Analysis

ABSTRACT Europe's twin green and digital transition seeks to align sustainability with digitalization, yet it remains unclear whether progress in twin transition‐relevant SDGs coincides with changes in economic freedom dimensions. Using an EU‐27 panel from 2000 to 2024, we examin...

Evidence-based interventions for vocational recovery in first-episode psychosis: A meta-analysis of employment and education rates

Background: Young people with first-episode psychosis experience high rates of disruption in work and education and consistently describe vocational participation as a core priority of recovery. This meta-analysis aimed to evaluate the effectiveness of evidence-based intervention...

Implant-Supported and Conventional Dentures: A Meta-Analysis in Older Adults

Statement of problem Edentulism is highly prevalent among older adults, with approximately 30% of adults aged ≥60 years affected by complete tooth loss in at least one dental arch. Conventional complete dentures (CCDs) often provide suboptimal retention and stability, negatively...

Diagnostic Methods for Detecting Dental Cracks: A Systematic Review

Background: Dental cracks are a common yet diagnostically challenging condition due to their asymptomatic clinical nature and difficulty in early detection. Accurate diagnosis is essential to prevent crack progression and potential tooth loss; however, no universally accepted dia...

Glycemic Patterns Assessed by Continuous Glucose Monitoring in People with Type 2 Diabetes Treated with Insulin Glargine 100 U/mL in Primary Care: The GPDetect Study

Hypoglycemia is a common complication in people with type 2 diabetes mellitus (T2DM) treated with basal insulin, yet its true prevalence in real-world primary care remains underexplored. This study used blinded continuous glucose monitoring (CGM) to assess glycemic patterns in pa...

Detailed study of non-equilibrium characteristics of quasi-neutral TNSA plasmas

In an experiment performed in November 2022 at the petawatt (PW) laser facility at Vega III located in Salamanca-Spain, we have studied the successful production of several radioisotopes using protons accelerated by the Target Normal Sheath Acceleration (TNSA) mechanism (Rodrigue...

Treatment-free remission after bosutinib discontinuation (BOSUTFR): results from a multicenter real-world study by the Spanish CML group

Treatment-free remission (TFR) is an established therapeutic goal for patients with chronic myeloid leukemia (CML) achieving sustained deep molecular response (DMR) on tyrosine kinase inhibitors (TKIs). However, evidence on TFR following bosutinib discontinuation remains limited....

Therapeutic management of axial spondyloarthritis: summary of 2024 update of the Spanish clinical practice guideline (ESPOGUIA)

Axial spondyloarthritis (axSpA) is a chronic inflammatory rheumatic disease associated with significant morbidity and impaired quality of life. Rapid advances in diagnosis, monitoring, and especially treatment over the past decade have increased the complexity of axSpA management...

Back to the Future of qEEG: Lifespan Normative Modeling of Spectral Ratios and Functional Indices with Potential Applications to Therapeutic Monitoring

Quantitative EEG (qEEG) provides objective, millisecond-resolution measures of brain dynamics. Despite decades of methodological advances, clinically relevant derived indices-spectral power ratios, cognitive-emotional state markers, and physiological parameters-are typically repo...