Universidad de Salamanca

Genomic and clinical landscape of RAS mutations in acute myeloid leukemia

RAS mutations are recurrent in acute myeloid leukemia (AML); yet, their genomic and clinical landscape remain poorly characterized. We analyzed centralized molecular profiling data in 8,553 patients with newly diagnosed AML. Of these, 1,775 (21%) harbored RAS mutations: NRAS in 1...

Effectiveness of a Physical Exercise Prescription Program in Primary Care to Improve Physical Fitness and Quality of Life in Adults Aged 65 Years and Older in a Rural Basic Health Area—Study Protocol for a Randomized Controlled Trial (PREFIS-AP)

Physical inactivity contributes substantially to morbidity, disability, functional decline, and premature mortality in older adults. General physical activity counselling in primary care does not necessarily translate into structured, individualized exercise prescription. PREFIS-...

Mediterranean Diet Adherence and Sleep Quality in Spanish Adults: Divergent Associations Between Subjective and Objective Measures

Objective: We aimed to examine the association between adherence to the Mediterranean diet (MD) and sleep quality assessed using both subjective and objective methods in a general adult population. Design: This is a cross-sectional study. Adherence to the MD was evaluated using t...

Validation of the International Working Group 2023 response criteria for higher risk myelodysplastic syndromes/neoplasms using the International Consortium for Myelodysplastic Syndromes VALIDATE database and a randomized phase III trial

Response assessment criteria in patients with higher-risk myelodysplastic syndromes/neoplasms (HR-MDS) have been updated in the 2023 International Working Group (IWG) criteria. However, validation of these criteria has been limited to date. We analyzed overall survival (OS) by be...

Pharmacological Analysis of P2Y Purinergic Receptors That Modulate the Rat Vasopressor Sympathetic Tone

Background/Objectives: Adenosine 5′-O-(β-thio)-diphosphate (ADPβS) is a stable analogue of adenosine diphosphate (ADP). In pithed rats, ADPβS produces (i) inhibition of both the cardioaccelerator sympathetic tone (via prejunctional P2Y12/P2Y13 receptors) and the vasodepressor sen...

Determinants of Gender-Based Violence in Ecuador

This study analyzed the determinants of gender-based violence (GBV) in Ecuador using microdata from the National Survey on Family Relations and Gender Violence against Women. Binomial logit models estimated the probability of women experiencing any type of GBV and each type (psyc...

The Defensorium unitatis christianae (1450) and the ethical-rational royal absolutism

Firstly, this article aims to highlight the links between Alfonso de Cartagena’s Defensorium unitatis christianae and Pablo de Santa María’s Scrutinium Scripturarum, with a view, on the one hand, to shedding light on the Thomist tradition that underpins both treatises, and, on th...

Teachers’ Perceptions of Generative Artificial Intelligence in Early Childhood and Primary Education: Barriers, Ethical Concerns, and Perceived Impacts

The growing integration of Generative Artificial Intelligence (GAI) into education has intensified the need to understand teachers’ perceptions of its implementation in the early stages of schooling. This study aimed to examine the barriers, ethical concerns, and perceived impact...

Gamified IMU Sensor-Based System for Training Head-Orientation Tasks in Healthy Teenagers: Event-Driven Architecture and Randomised Pilot Feasibility Study

Sensor systems integrated with gamified environments have increasingly been incorporated into the monitoring of musculoskeletal disorders. This study evaluates the operational feasibility of a motion-capture system based on an inertial measurement unit for training head-orientati...

Replication package for "Production-Oriented Evaluation and Testing of LLM-Based Agents: A Systematic Literature Review"

Replication package for the systematic literature review "Production-Oriented Evaluation and Testing of LLM-Based Agents: A Systematic Literature Review" (revised version, submitted to Information and Software Technology; first submitted as "Evaluation and Testing of LLM-Based Ag...

Replication package for "Production-Oriented Evaluation and Testing of LLM-Based Agents: A Systematic Literature Review"

Replication package for the systematic literature review "Production-Oriented Evaluation and Testing of LLM-Based Agents: A Systematic Literature Review" (revised version, submitted to Information and Software Technology; first submitted as "Evaluation and Testing of LLM-Based Ag...

Breeding bird data from the Côa River Basin (Portugal): twenty-six years of change in a Mediterranean landscape in transition

Breeding bird data from the Côa River Basin (Portugal): twenty-six years of change in a Mediterranean landscape in transition This data package brings together standardized breeding-bird transect data collected in the Côa River Basin, north-eastern Portugal, over twenty-six years...

Zinc Homeostasis in Brucella ovis Under Zinc Scarcity: Characterization of the ZnuABC Zinc Import System and of a Newly Identified Gene of the Zur Regulon

The zinc import system ZnuABC is essential for the virulence of smooth (bearing O-polysaccharide chains) zoonotic Brucella species but remains uncharacterized in the non-zoonotic rough (lacking O-chains) species Brucella ovis, the causative agent of a type of ovine brucellosis of...

A New Tucker Model for Three-Way Functional Data: FTucker-3

This paper introduces FTucker-3, a basis-preserving Tucker framework for three-way functional data in which each tensor cell is a function. Functional observations are represented in a common finite basis, organized as a fourth-order coefficient tensor, and reduced only along the...

“Health as Work”, Structural Vulnerability Shaping Migrant Health in Non-Metropolitan Spain: A Qualitative Study

Background/Objectives: Migrants often experience health inequities resulting from administrative insecurity, precarious employment, and barriers to healthcare access. Although non-metropolitan areas are increasingly important destinations for migrant populations, evidence on thei...

Three clinical and immunological phenotypes of systemic lupus erythematosus onset identified through clustering analysis: data from the RELES registry

Abstract Background Systemic lupus erythematosus (SLE) shows heterogeneous clinical expression at onset, complicating early characterisation and risk assessment. We aimed to identify SLE phenotypes emerging after diagnosis and assess their clinical relevance. Methods We analysed...

Scattering of wobbling vortices

A bstract We investigate the dynamical role of internal vibrational modes in the Abelian Higgs model, focusing on how Derrick-type excitations modify vortex dynamics and scattering processes. We study the scattering of excited vortices and show that the interplay between spectral...

Political Endorsements by TikTok Influencers: Parasocial Interaction, Identification, and Support for Political Candidates

This study examines political persuasion on TikTok by testing how influencers’ direct address and media source labels shape audience responses to a political endorsement video. Using a preregistered 2 × 2 online survey experiment with 486 U.S. adults, we found that participants e...

Effectiveness of Interventions for Reducing Loneliness Among Adult Cancer Survivors: A Systematic Review and Meta-Analysis

Background/Objectives: Loneliness in adult cancer survivors is a frequent and disruptive psychosocial sequela with important consequences for overall health. Psychosocial interventions designed to address this issue are crucial. This systematic review and meta-analysis aimed to e...

Beyond rare gases: Cooling of trapped BN− ions by H2 molecules

Quantum dynamics of collisional cooling of the BN- anion in a cold trap is carried out by using the ortho- and para-H2 molecules as a buffer gas. The calculations are performed using the full four-dimensional interaction potential energy surface in which both BN- and H2 are treat...