Universidad de Los Andes, Chile

A Structured Framework for Translation of the ACNS Standardized Critical Care EEG Terminology Into Spanish

Purpose: The American Clinical Neurophysiology Society (ACNS) Critical Care EEG Terminology provides standardized language for describing electroencephalographic (EEG) patterns in critically ill patients but has not been formally translated into Spanish. We aimed to develop a con...

Platelet-derived mitochondria: from release to therapeutic applications

Abstract Among their diverse functions, platelets enable intercellular communication through the release of their contents, including functional mitochondria. Given their high circulatory abundance, platelets represent a readily accessible source of these organelles. Consequently...

Acceptability and feasibility of implementing the I Can Problem Solve (ICPS) program among preschoolers in Chile: results of a pilot randomised controlled trial

Mental health disorders often begin early in life and are disproportionately prevalent among children in low-resource settings. School-based social-emotional learning (SEL) programs have shown promise in promoting cognitive and emotional skills in young children, yet few have bee...

Horizontal mitochondrial transfer and mitochondrial transplantation in skin: protection against UVR-induced ROS damage and enhancement of cell proliferation and wound healing

Skin homeostasis, protection against ultraviolet radiation (UVR), and wound repair depend on coordinated interactions among melanocytes, keratinocytes, and fibroblasts. Horizontal mitochondrial transfer (HMT) is a naturally occurring form of intercellular communication in which m...

Evolution of striking dominance in Ultimate Fighting Championship: A cross-temporal analysis of factors associated with victory

This study examined the evolution of action frequencies associated with victory in UFC bouts across three distinct eras (2003–2004, 2013–2014, and 2023–2024). A total of 1722 fights were analyzed: Early Era (2003–2004; n = 77), Transition Era (2013–2014; n = 813), and Modern Era...

Adult Cystic Nephroma: Cyst De-roofing as a Parenchyma-sparing Alternative. A Case Report and Review of the Literature

Background. Cystic nephroma is a benign multilocular renal tumour with a bimodal age distribution and fewer than 200 reported cases. In adults it presents almost exclusively in women in the fourth decade, and imaging cannot separate it reliably from a malignant cystic mass, so th...

Subglottic Pressure and Immersion Depth: Key Determinants of Voice Outcomes in Water Resistance Tube Exercise

Purpose: The present study aimed to evaluate the effects of different immersion depth levels and subglottic pressure (P sub ) levels on the oscillatory features of oral pressure (P oral ; frequency, amplitude, and regularity), the degree of glottal adduction, and the subjective p...

Viridicatin from the Antarctic Fungus Penicillium sp. Protects Human Microglia and Patient-Derived Peripheral Immune Cells Against Oxidative Stress

Neurodegenerative diseases remain a major therapeutic challenge, with oxidative stress playing a central role in central and peripheral immune system dysfunction that leads to neuronal loss. Natural products from extreme environments represent an underexplored source of neuroprot...

Machine Learning-Based First-Trimester Antenatal Risk Prediction for Adverse Maternal and Neonatal Outcomes: Multicenter Model Development Study.

Background: Maternal outcomes remain inequitable worldwide. Severe morbidity persists, and current risk assessment tools are largely arbitrary, focusing on biomedical factors while overlooking social determinants of health. There is a need for data-driven AI models to improve ear...

Rare Diseases as Epistemic Objects: Exploring the Moral Role of Health Systems

ABSTRACT This article explores how rare diseases reveal the moral and epistemic foundations of healthcare systems. Based on narrative interviews with 11 Chilean patients and 10 professionals, this study shows how the absence of standardised protocols—such as clinical guidelines,...

A Gap Analysis of Deep Brain Stimulation for Childhood‐Onset Movement Disorders

BACKGROUND: Deep brain stimulation (DBS) is an established and increasingly utilized therapy for childhood-onset movement disorders. However, pediatric DBS poses unique challenges that are not adequately addressed by adult-derived paradigms. OBJECTIVE: To identify key gaps in the...