Universidad de la República de Uruguay

From default protocols to species-specific design: optimizing epi-ddRADseq for plant methylome profiling

DNA methylation adds an important layer of information to studies of plant diversity, adaptation, and crop improvement. However, genome-wide methylation profiling often relies on standardized commercial workflows optimized for a limited number of model or well-established species...

An Immobilized Marine Glycosyltransferase Acts as a Stabilized Biocatalyst for the Synthesis of Mannosylated Phosphoisoprenoids

Glycosylated phosphoisoprenoids constitute valuable bioactive molecules and starting materials for complex glycosylation cascades. Herein we report the identification and the functional characterization of a newly identified polyprenyl phosphomannose synthase from the marine micr...

Development and Field Evaluation of a Prototype Bacterial Inoculant for Cuban Rice Under Reduced Nitrogen Fertilization

Rice is a priority crop in Cuba, and bacterial inoculants could help sustain productivity under reduced mineral fertilizer inputs. However, evidence describing the main stages involved in developing these bioproducts in the country remains limited. This study aimed to evaluate th...

Heat shock transcription factor-1 and heat shock protein 90: insights into post-insemination endometritis

CONTEXT: In mares, post-breeding endometritis is a major cause of embryo mortality. In other species, endometrial function and pathology seem to involve heat shock protein-90 (HSP90), a factor regulated by heat shock transcription factor-1 (HSF-1). AIMS: To study the relationship...

Partially hyperbolic geodesic flow via conformal deformation

This paper presents a new construction of non-Anosov partially hyperbolic geodesic flows. Our construction is closely related to the construction presented in [10] , the novelty is the use of conformal deformations to produce the examples. Some of the necessary conditions appear...

A Data-Driven Validation Methodology for a Multi-City Solar Chimney Dataset in Smart-City Applications

This article presents a methodology for a validated multi-city parametric dataset for data-driven assessment of single-channel solar chimneys as energy-efficient components of smart-city buildings. The dataset covers Mexico City, Hermosillo, Mérida, Monterrey, Toluca, and Villahe...

Unified Formulation of the Pentadimensional (5D) Space-Time-Matter Framework: Inertial Quantization, Proper-Time Sampling, and Quantum-Gravitational Scales

We present a unified analytical formulation of the Space-Time-Matter framework on a non-compact, smooth five-dimensional manifold M5=M4×Rχ under a test-field approximation (RAB=0). Addressing prior theoretical gaps and operator constraints, we demonstrate that: (1) proper time is...

Genetic variability and DMI fungicide sensitivity of the Alternaria alternata species group associated with wheat in Uruguay

This study provides the first assessment of occurrence, genetic variability, and DMI fungicide sensitivity of wheat-associated Alternaria spp. in Uruguay. Seventy asymptomatic wheat grain samples collected during the 2022 harvest were analyzed. Alternaria spp. were detected in al...

Inducible chronic NAD deficiency in mice reveals multi-systemic phenotypical, metabolic, and transcriptional changes

Nicotinamide adenine dinucleotide (NAD) is a metabolic cofactor regulating energy metabolism, epigenetics, DNA repair, and signaling. Although NAD declines with vitamin B3 deficiency, disease, and aging, systemic consequences of chronic depletion remain unclear. Here, we characte...

Computational Methods in Physical Virology: A Critical Perspective across lengths and timescales

Physical virology investigates viral particles by focusing on their assembly, stability, mechanics, and interactions with host cells, neutralizing antibodies, and surfaces. Within this field, computational virology is becoming an indispensable pillar, serving as a "computational...

Differential responses of Uruguayan onion cultivars to bacterial bulb rot and leaf blight caused by Pantoea spp. and Burkholderia sp

Bacterial diseases caused by Pantoea spp. are an emerging constraint for onion production in Uruguay. This study evaluated bacterial aggressiveness and the response of Uruguayan onion cultivars and breeding lines. P. ananatis MAI6032, P. agglomerans MAI6045, and Burkholderia sp....

New genera and species of lungfish (Sarcopterygii, Dipnoi) from the Upper Jurassic of western Gondwana, in the Jatobá basin, northeastern Brazil

The present study describes three new species and two new genera of lungfish from the Upper Jurassic (Tithonian) of the Aliança Formation (Jatobá Basin), in the state of Pernambuco, northeastern Brazil. The new taxa, Ceratodus ibimiriensis sp. nov., Tekoaceratodus pernambucensis...

Electron transfer in electrocatalytic reactions: effective symmetry factors

Abstract The evaluation of electron transfer kinetics at electrochemical interfaces plays a fundamental role in optimizing the efficiency of electrocatalytic reactions of technological interest. Different approaches to this topic arose from the analysis of experimental data that...

Comparative Transcriptomic Analysis of Potato and Tomato Responses to Botrytis cinerea Infection

Botrytis cinerea causes gray mold disease in numerous plant species, including economically important solanaceous crops. To investigate the molecular interaction between B. cinerea and Solanum tuberosum, we performed dual RNA-seq analyses of infected potato leaves at 24 and 72 h...

Development of A Reduced‐Fat Mayonnaise Using Double Emulsions ( W 1 /O/W 2 ) With the Addition of Natural Rosemary Antioxidants Obtained by Green Chemistry Extraction

ABSTRACT W 1 /O/W 2 double emulsions are promising systems for formulating reduced‐fat foods, as part of the fat is replaced by water (W 1 ) while maintaining texture and rheological properties. However, their high susceptibility to lipid oxidation requires the addition of antiox...

Weightflow: Reproducible, recipe-aware survey weighting for official statistics in R

Weighting is a governed, reproducible subprocess in the production of official statistics: design weights are refined through a cascade of adjustments (unknown eligibility, out-of-scope units, within-household selection, nonresponse, and calibration to known totals), after which...

Organometallic compounds as antimicrobial agents: emerging chemical types, mechanistic insights and future directions

INTRODUCTION: The relentless surge of antimicrobial resistance (AMR) across bacterial, fungal, viral, and parasitic pathogens constitutes a catastrophic threat to global healthcare, rapidly rendering conventional organic anti-infectives obsolete and demanding the urgent developme...

INPP5E interactome reveals novel connections to growth factor signaling

Abstract Primary cilia are sensory cell membrane protrusions whose malfunction causes diseases known as ciliopathies. Joubert syndrome (JBTS) is a rare recessive ciliopathy causing brain malformations and kidney cysts, among other manifestations. A key player in JBTS is INPP5E, a...

Characterization of the ecological impacts of prescribed fire in South America: a review

Prescribed fire has been shown to offer substantial benefits to both human populations and ecosystems, but it can also cause environmental harm, such as reduced air quality and negative impacts on sensitive species. To support the appropriate use of prescribed fire, stakeholders...

Sensorimotor teleology and goal-directedness. An organismic framework for normative behaviour

Abstract Teleosemantics explains meaning by appealing to the biological norms that make error possible, but most work in the field still anchors those norms in evolutionary “selected-effect” functions. We develop an organismic alternative grounded in the self-maintenance of auton...