Universidad de Alcalá

Ga3+ Replacing of Fe3+ as a “Trojan Horse” Antimicrobial Strategy: Modeling the Process within Bacterial Catalase–Peroxidase KatG

Abstract Replacement of Fe3+ by Ga3+ has emerged as a promising “Trojan horse” antimicrobial strategy in response to the growing threat of antibiotic-resistant bacteria. Because many bacterial proteins hijack host iron to sustain essential redox processes, substitution with redox...

Empirically Derived Whole-Diet Patterns and Multidimensional Adiposity in Emerging Adulthood: A Cross-Sectional Study of Geographically Diverse Students at a UK University

Background: Emerging adulthood is a period in which dietary behaviours may become established before their longer-term effects on adiposity are fully expressed. Evidence linking empirically derived whole-diet patterns with multiple adiposity phenotypes remains limited in narrow-a...

Disentangling the species diversity of Inocybe sect. Petiginosae (Inocybaceae) in Europe and North America

Abstract A multigene phylogenetic assessment of European and North American species in Inocybe sect. Petiginosae based on ITS, LSU and RPB2 rDNA sequence data was undertaken to enable a systematic revision. Specimens collected in northern boreal to arctic-alpine ecosystems were s...

Expired endoscopic devices remain sterile and functional: an international multicentre study challenging current shelf-life criteria

Background and study aims Expired medical devices represent an environmental and economic concern, yet their magnitude and true shelf life remain poorly defined. We aimed to quantify the volume and cost of expired endoscopic devices and evaluate their sterility and functionality...

Antimicrobial Composite Nanofiber Membranes Containing Cross-Linked β-Cyclodextrin Encapsulated Essential Oils

Abstract Membrane biofouling leads to low permeate quality and increased operational costs due to the need for frequent physical and chemical cleaning. Incorporation of antimicrobial agents such as essential oils (EOs) into polymeric membranes presents a promising solution to mit...

Coordinating Internal and External HMIs for Cooperative Driver-Pedestrian Situation Resolution

Traffic interactions between vehicles and pedestrians are inherently uncertain due to the dynamic nature of the interaction partners’ behavior. Resolutions require mutual understanding of the situation and each other’s intention, typically achieved through explicit and implicit c...

Three clinical and immunological phenotypes of systemic lupus erythematosus onset identified through clustering analysis: data from the RELES registry

Abstract Background Systemic lupus erythematosus (SLE) shows heterogeneous clinical expression at onset, complicating early characterisation and risk assessment. We aimed to identify SLE phenotypes emerging after diagnosis and assess their clinical relevance. Methods We analysed...

Coated or chewable Aspirin and a hybrid air pollution mitigation strategy in patients with atherosclerotic disease: Rationale and Design of the COATED-AIR Randomized Trial.

BACKGROUND: Although enteric-coated aspirin is widely used instead of chewable formulations in patients with atherosclerotic cardiovascular diseases (ASCVD), its effects on cardiovascular and gastrointestinal outcomes remain uncertain. Separately, air pollution is a driver of car...

Otherness, class and labor: Internal migration and emigration in four Spanish novels of late Francoism

This article examines four Spanish novels published during the late Francoist period: La mina (1959), by Armando López Salinas; Ajena crece la yerba (1962), by Ramón Solís; Hemos perdido el sol (1963), by Ángel María de Lera; and Cacereño (1969), by Raúl Guerra Garrido. The selec...

Antiproteinuric Response to Finerenone in Diabetic Kidney Disease: Responder and Non-Responder Subgroup Analysis of the FINDKDLATAM Study

Background/Objectives: Albuminuria is an early marker of kidney damage and an independent predictor of adverse outcomes, making its reduction a key therapeutic goal. Finerenone, a selective nonsteroidal mineralocorticoid receptor antagonist, has demonstrated renal and cardiovascu...

HANNIBAL’S APPOINTMENT RECONSIDERED: CRISIS, LEGITIMACY, AND THE REPUBLICAN INSTITUTIONS OF HELLENISTIC CARTHAGE

The assassination of Hasdrubal in 221 bc created a power vacuum in Carthaginian leadership, echoing the crisis that followed Hamilcar’s death eight years earlier. Yet Hannibal’s subsequent appointment has attracted surprisingly limited attention in modern scholarship. This articl...

Integrating ecology and economics: European honey buzzards as ecosystem service providers against yellow-legged hornets

The economic valuation of ecosystem services is an essential tool for integrating environmental considerations into decision-making processes. However, the valuation is challenging as many of these services lack formal market values. This study evaluates the role of the European...

Buried in the pantry: using archaeoentomology to assess cave reuse at the pre-Hispanic site of Cruz de la Esquina

Entomology, the study of insects, is an integral part of modern forensic science and can also make substantial contributions in archaeology. Here, the authors report on archaeoentomological analyses conducted within the Cruz de la Esquina funerary cave (Acusa Seca, Gran Canaria,...

Reading the Void: A Reconstructive Hypothesis for a Service Staircase at the Infantado Palace in Guadalajara Using TLS

This study examines the relevance of Terrestrial Laser Scanning (TLS) for documenting and reconstructing architectural heritage elements that have partially or completely disappeared over time, using the remains of the service staircase of the Infantado Palace (Guadalajara) as a...

Balancing Hydrogen Bonding and Crystallinity in Enzymatically Functionalized Lignin–Poly(vinyl alcohol) Composite Films

Poly(vinyl alcohol) (PVA) is a promising biodegradable polymer; however, its reliance on petroleum and incompatibility with raw lignin additives hinder sustainable PVA composite development. In this study, mechanically robust PVA/functionalized acid-soluble lignin (fLGAS) composi...

A cluster-randomized controlled trial of a family-based psychosocial intervention to prevent childhood obesity from preschool ages: the PRESAFALIN study protocol

Abstract Background: Childhood obesity is a major global concern, and Spain's high obesity rates highlight the urgent need for effective and innovative interventions in early age. The PRESAFALIN study aims to promote parental competence, self-efficacy, and resilience to improve c...

Challenges in the diagnosis of autism spectrum disorder among Latin American migrant communities in the Netherlands: a qualitative study

Purpose This study aims to examine how intervening social factors influence autism spectrum disorder (ASD) diagnosis in Latin American migrant families living in the Netherlands. Focusing on social support, language proficiency and perceptions of discrimination in health care, th...

Scientific Basis of Sherry Wine Food Pairing: Integrating Consumer Perception, Sensory Analysis, and Volatile Profiling

Sherry wines from the Jerez–Xérès–Sherry PDO are globally renowned for their unique sensory complexity, yet their food pairing guidelines have traditionally remained empirical. This study aims to establish a scientific foundation for these harmonies by integrating consumer percep...

Functional assessment of inherited myeloid neoplasm‐associated SAMD9L germline variants via Monoallelic CRISPR modelling

Summary While the majority of myeloid neoplasms are sporadic, the increasing application of germline genetic testing has led the World Health Organization to designate ‘ Myeloid malignancies with germline predisposition’ as a distinct clinical entity, carrying major implications...

Tumor-infiltrating lymphocytes differ across MammaPrint® classifications in breast cancer

Abstract MammaPrint® refines risk stratification in early oestrogen receptor-positive, HER2-negative breast cancer, evolving from a binary to a four-tier classification (UltraLow, Low, High-Risk1, High-Risk2). The relationship between routine histopathological features, immune in...