Universidad Complutense de Madrid

Blood-brain barrier opening with focused ultrasound reduces neuromelanin in a non-human primate model.

Age-related accumulation of neuromelanin (NM) has been implicated in the intrinsic vulnerability of catecholaminergic neurons in Parkinson's disease. Postmortem studies in Parkinson's disease patients have revealed elevated intracellular and extracellular NM in the substantia nig...

Application of Photogrammetry and Mesh Comparison in the Study of Human Cranial Morphology

ABSTRACT Photogrammetric methods for generating three‐dimensional (3D) models are becoming increasingly widespread in the fields of archaeology and biological anthropology. In particular, the study of the variability of skull morphology (generated by the ancestry of the individua...

The Effects of Political Misalignment With the Government on Individual Well‐Being and Mental Health

ABSTRACT While psychological well‐being and life satisfaction have been widely studied, the mental health effects of political events remain understudied. This paper examines how the ideological distance between individuals and their government affects well‐being and mental healt...

Association between salivary alkaline phosphatase levels and periodontal disease: a systematic review and meta-analysis

This updated meta-analysis evaluated salivary alkaline phosphatase (ALP) levels in individuals with gingivitis and periodontitis compared to periodontally healthy individuals. The review followed PRISMA guidelines and was registered in PROSPERO (CRD420251273461). Searches were co...

Near-atomistic simulations reveal the molecular principles that control chromatin structure and phase separation

Abstract Understanding how chromatin’s physicochemical properties shape its emergent organization is central to deciphering genome function. To address this, we present OpenCGChromatin, a high-performance coarse-grained model that achieves near-atomistic simulations of chromatin...

A feasibility pilot study of an AI-based emotional support application (TerapIA) in a Spanish-speaking community population: recruitment, retention and parameter estimation for a controlled trial

Before running a controlled trial of an emotional support application, it is worth checking that the trial can actually be run. We present a feasibility pilot study of TerapIA, the AI-based emotional support application of LenguajeNatural.AI, with a pre/post design and a control...

Western diet induces MASLD and major transcriptional reprogramming in the liver-gut axis of early zebrafish larvae

Abstract Metabolic dysfunction-associated steatotic liver disease (MASLD) is linked to western diet and sedentary lifestyle. While larval zebrafish are powerful discovery tools, standardized diets inducing early-stage MASLD are lacking. Here, we developed and early-stage zebrafis...

The Weak Banach–Saks Property for Hölder Spaces

ABSTRACT We investigate the weak Banach–Saks property in the setting of Hölder spaces over metric spaces. We show that, for every infinite metric space and every , the Hölder space fails to have the weak Banach–Saks property.

Contested Liberalisms in Mexico: Popular Liberalism, the Fourth Transformation, and the Struggle over Constitutional Identity

Mexico's Cuarta Transformación (4T) is usually read as one instance of a global illiberal turn. This article argues instead that the Mexican constitutional conflict is internal to the liberal-republican tradition: rival projects each claim the mantle of liberalism to define who c...

Inflammatory Pseudotumour in Common Seal ( Phoca vitulina ): A Case Report

Pinnipeds, including seals, sea lions and walruses, are marine mammals susceptible to a variety of pathological conditions. Although neoplastic lesions in these species are receiving increased attention, relatively little information is available compared to neoplastic studies in...

HIV-1 Drug Resistance in Mother–Infant Pairs in Southern Mozambique

This prospective nested cohort (EARTH) study evaluated drug resistance mutations and outcomes among 79 (31 with genetic results) early-treated Mozambican children living with HIV, followed for 50 months. Mortality reached 20.3%. Drug resistance mutations were detected in 58.1% of...

‘The Left Turns Us Into a Collectivity’. Political Discourses on LGBTIQ+ Rights Among Right-Wing LGB+ Individuals in Spain

Electoral sociology has shown that the LGBTIQ+ constituency differs significantly from the cisheterosexual population, exhibiting greater affinity for liberal values and progressive parties. However, in recent years, a LGB+ minority that aligns with right-wing ideology and partie...

Determinants of parental satisfaction in nurse–parent communication during pediatric hospitalization: a systematic review

Children with complex medical conditions require frequent interactions with the healthcare services and multidisciplinary teams. During pediatric hospitalization, effective nurse-parent communication is essential to family experience and satisfaction. To provide a synthesis of th...

Fault Slip Reversals Preceded the Intraplate 2021 Earthquake Series in the Vienna Basin (Central Europe)

Abstract Fault‐slip reversals indicate transient stress changes and may illuminate earthquake preparation processes. Here we present high‐resolution observations of sub‐millimetric creep and slip reversals on the Altaquelle Fault, a Quaternary normal fault in the southern Vienna...

MRI Anatomy of Pseudopus apodus: A Descriptive Study with High-Field and Low-Field MRI

Pseudopus apodus is an anguimorph lizard belonging to the order Squamata. Anatomical information on this species remains limited, particularly regarding soft tissues, and has primarily focused on the axial skeleton of both living and fossil specimens. Recently, the anatomy of its...

Firm growth, age and the intensity of international trade: evidence from Ecuadorian manufacturing firms

Purpose This paper examines whether firm age moderates the relationship between international trade intensity and firm performance, and whether this relationship differs across the firm-growth distribution. Design/methodology/approach Using a comprehensive administrative panel of...

Antibody-drug conjugate engineering: from design to efficacy and safety

Antibody–drug conjugates (ADCs) represent a rapidly expanding class of targeted cancer therapeutics that combine the high selectivity of monoclonal antibodies with the potent cytotoxic activity of small-molecule drugs. Their clinical success relies on the simultaneous optimizatio...

Biocatalytic carbohydrate modification using lipase from Stutzerimonas stutzeri : From regioselective hydrolysis to glycolipid synthesis

Selective carbohydrate functionalization remains one of the major challenges in synthetic chemistry owing to the presence of multiple hydroxyl groups with similar reactivity. Among the available biocatalysts, lipases have emerged as valuable tools for the regioselective modificat...

Clinical Complications of Fixed Anterior Prostheses After Traumatic Premature Loss of Primary Maxillary Incisors: A Retrospective Cohort Study

BACKGROUND/AIM: Premature loss of primary maxillary incisors after traumatic dental injuries may require secondary rehabilitation in preschool children. Evidence on complications associated with fixed anterior prostheses in this context remains limited. This retrospective cohort...

Soil moisture as the dominant driver of CO 2 efflux in Mediterranean urban green spaces: evidence for a Gaussian temperature response and mechanistic modelling of moisture and temperature interactions

Soil respiration is a key component of the global carbon cycle, yet its dynamics in urban Mediterranean environments remain poorly understood. This study investigated the effects of soil temperature, soil moisture, and plant community on soil CO 2 efflux in urban green spaces of...