Universidad Bernardo O'Higgins

Effects of Zinc Supplementation on Glycemic Control, Insulin Resistance, Inflammation and Oxidative Stress in Diabetes: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials

ABSTRACT Objectives Diabetes mellitus (DM) is a chronic metabolic disorder characterized by insulin resistance, impaired insulin secretion, and increased cardiometabolic and inflammatory burden. Zinc plays a key biological role in insulin synthesis, storage, signalling and antiox...

Impact of Spatial Knowledge on Fire Evacuation Performance in Large Buildings: An Integrated Simulation Approach

This study examines human evacuation performance in complex building environments under highly uncertain fire conditions, with a focus on how spatial knowledge and decision-making strategies influence exposure to hazardous conditions during emergencies in smart building contexts....

Strategic responses to digital disruption: lessons from online business education in Chile

Purpose This paper provides a strategic and capability-based longitudinal analysis of the evolution of online undergraduate business education in Chile between 2012 and 2024. Rather than treating digital expansion as a purely technological shift, this study aims to examine how bu...

Prevalence of Persistent Left Superior Vena Cava in Patients with Congenital Heart Disease: A Systematic Review with Meta-Analysis

Persistent left superior vena cava (PLSVC) is the most frequently reported anatomical variant of the thoracic systemic venous system. While its association with congenital heart disease (CHD) is well recognized, its prevalence within CHD populations and its relative occurrence co...