Universidad Andrés Bello

Unraveling theMolecular Basis of NSD3 AllostericActivation Driven by Nucleosome Binding: A Multiscale MD and QM/MMApproach

Abstract Nuclear receptor-binding SET domain 3 (NSD3) is a methyltransferase responsible for mono- and di-methylation of histone H3 lysine 36, whose hyperactivation is linked to accelerated cancer cell proliferation. Isolated NSD3 is autoinhibited due to a conformation that preve...

A Governed NL-to-SQL Architecture for Reliable Clinical Data Querying and Outpatient Schedule Monitoring

The deployment of natural-language-to-SQL (NL-to-SQL) systems in primary healthcare requires more than accurate query generation: it also requires governed data access, robustness to local terminology, and reliable handling of ambiguous user requests. This study evaluated a pilot...

Prevalence of Persistent Left Superior Vena Cava in Patients with Congenital Heart Disease: A Systematic Review with Meta-Analysis

Persistent left superior vena cava (PLSVC) is the most frequently reported anatomical variant of the thoracic systemic venous system. While its association with congenital heart disease (CHD) is well recognized, its prevalence within CHD populations and its relative occurrence co...

Low Back Pain as a Nursing Education Priority

Low back pain (LBP) is the leading cause of years lived with disability globally, and a major rehabilitation priority, yet nursing education often does not translate burden evidence into first-contact actions across care settings. This article aimed to develop a nursing education...