Union Hospital

The effect of compression stockings on patients with lower extremity venous ulcers: A meta-analysis

Objective This study aims to systematically evaluate the efficacy and safety of compression stockings compared with other active compression modalities and surgical interventions in the management of venous leg ulcers, and to explore the impacts of intervention duration, reported...

Intratumoral and peritumoral delta radiomics of MRI predicts overall survival to targeted therapy in colorectal cancer with liver metastases

To develop and validate a hybrid prognostic model integrating clinical, MRI, and radiomics features for predicting overall survival (OS) in patients with colorectal cancer liver metastases (CRCLM) undergoing targeted therapy. This retrospective, multicenter study included 118 CRC...

Intrapartum ultrasound in the second-stage labor: a meta-analysis and evidence appraisal of clinical outcomes and safety

Abstract Background Accurate assessment of fetal head position and descent during the second stage of labor is essential for safe decision-making, but digital examination is subjective and operator-dependent. Intrapartum ultrasound has been proposed as an objective adjunct, yet i...

Combined Bioinformatic Analysis and RNA Sequencing Uncover Key Tinnitus-Related Molecules in the Cingulate Gyrus

Tinnitus arises from maladaptive plasticity and abnormal synaptic function, not only in auditory pathways but also in limbic regions. Among these, the cingulate gyrus plays a pivotal part in shaping the emotional burden and sensory filtering disturbances often seen in tinnitus pa...

Gut microbiome mediates the protective effects of empagliflozin on experimental abdominal aortic aneurysm formation and progression

Abdominal aortic aneurysm is a life-threatening vascular disease lacking effective pharmacotherapies. This study aimed to investigate the protective effect of empagliflozin, a sodium-glucose cotransporter 2 (SGLT-2) inhibitor, against angiotensin II (AngII)-induced AAA in ApoE −/...

Association of C-reactive protein-triglycerides-glucose index-waist-to-height ratio with mortality in metabolic dysfunction-associated steatotic liver disease (MASLD): evidence from two cohort studies

Abstract Background MASLD significantly increases the risk of cardiovascular events and all-cause mortality (ACM). The impact of the C-reactive protein-triglyceride-glucose index (CTI) and its derivatives on mortality in the MASLD population remains unclear. This study aimed to i...

A prognostic model for pyrrolizidine alkaloids-induced hepatic sinusoidal obstruction syndrome based on sarcopenia

Sarcopenia has been shown to be associated with the prognosis of patients with liver cirrhosis, hepatocellular carcinoma, liver failure. However, the impact of sarcopenia on survival has not been investigated in patients with pyrrolizidine alkaloids (PAs)-induced hepatic sinusoid...

Parenting styles and fertility intention: Mediating effects of childbearing beliefs and psychological resilience

China's declining fertility rate is partly due to low fertility intention among childbearing population. To understand family influence on young people's fertility intention and its underlying mechanisms, this study examines how parenting styles (authoritarian vs. permissive) aff...

Exploring the potential role of ADRB1 as a suppressor gene and prognostic biomarker in lung adenocarcinoma: a comprehensive bioinformatics analysis

Lung adenocarcinoma (LUAD) is the most common pathological subtype of lung cancer. Sympathetic activation remodels the tumor microenvironment through β-adrenergic receptors (β-ARs) and is associated with malignant progression. Research mainly focuses on β 2 -AR, while the role of...

Genotype-phenotype correlations in HNF1B-associated disease: a systematic review

Multiple organ systems can be affected by pathogenic variants in the HNF1B gene, with renal phenotype usually being the initial presentation. However, the genotype-phenotype correlations in HNF1B -associated disease remain unclear. To further explore the genotype-phenotype correl...

Nomograms based on clinical characteristics and baseline dual-layer spectral detector computed tomography imaging parameters: potential clinical utility in predicting the efficacy of first-line lymphoma treatment

Abstract Background Spectral computed tomography (CT) is considered a useful tool for predicting tumor treatment response and survival. However, its role in lymphoma treatment remains unclear. The purpose of this study was to develop spectral CT-based nomogram for predicting resp...

Clinical outcomes of combined hepatic arterial infusion chemotherapy with targeted or immunotherapy in advanced hepatocellular carcinoma

This retrospective study aimed to evaluate the efficacy and safety of combining hepatic arterial infusion chemotherapy (HAIC) with tyrosine kinase inhibitors (TKIs) or immune checkpoint inhibitors (ICIs) versus HAIC alone for the treatment of advanced hepatocellular carcinoma (HC...

Common SAEs and their impact on the prognosis of children treated with the CCCG-ALL-2015 protocol: a retrospective multicentre Chinese study

This study was intended to evaluate common serious adverse events (SAEs) and analyze their effects on the prognosis of acute lymphoblastic leukemia (ALL) children. We retrospectively collected the data of 7640 consecutive ALL children with/ without SAEs who were enrolled in CCCG-...

PLL‐g‐HPA Hydrogel Microneedles Loaded With Rhoifolin Target Macrophages to Alleviate Fibroblast Senescence for Diabetic Wound Healing

In this study, we demonstrate that during diabetic wound healing, interleukin-11 (IL-11) promotes the M1 polarization of macrophages, which subsequently triggers fibroblast senescence through the enhanced release of pro-inflammatory cytokines IL-1β and IL-6. Notably, Rhoifolin (R...

Visualized self-propelled nanorobots overcome tumor barriers for boosted photothermal-nanocatalytic synergistic therapy against triple-negative breast cancer

Conventional nanozyme-based therapeutics for triple-negative breast cancer (TNBC) are severely hindered by insufficient tumor penetration and lysosomal degradation-induced enzyme inactivation, crippling therapeutic efficacy. Herein, we rationally construct visualized dual-propell...

Sepsis: advances in diagnosis, management, and long-term outcomes—a narrative review

Abstract Sepsis is a complex and highly heterogeneous syndrome that resulted in approximately 11 million deaths worldwide in 2017 due to multiple organ failure, posing a serious threat to human life and health. With the advancement of medical technology, the definition of sepsis...

A Novel Mouse Model for Venous High-Load Remodeling Induced by Unilateral Jugular Vein Transection

Chronic venous disease (CVD) is a prevalent peripheral vascular disorder characterized by vascular remodeling driven by hemodynamic overload, yet available animal models are limited by high surgical difficulty and unstable induction efficiency. Here, we developed a novel mouse ve...

Development and validation of a knowledge, attitude, and practice questionnaire for management of metabolic complications after solid organ transplantation among medical staff

Metabolic diseases are common complications after solid organ transplantation (SOT) and significantly affect recipients’ quality of life and long-term survival. To our knowledge, no validated questionnaire specifically evaluates medical staff’s knowledge, attitude and practice (K...

Development and preliminary psychometric evaluation of an oral health questionnaire for chronic kidney disease (CKD-OHQ)

Oral health problems are common among patients with chronic kidney disease. Chronic kidney disease is associated with a broad range of oral manifestations, while poor oral health may accelerate chronic kidney disease progression, increase the risk of complications, and contribute...

Efficacy evaluation of flap repair after radical excision for axillary hidradenitis suppurativa

The data that support the findings of this study are available from the corresponding author upon reasonable request.