UNC Lineberger Comprehensive Cancer Center

ICD ‐10‐ CM ‐Based Algorithms to Identify Bacteremia Incorporating Pathogen‐Specific Codes: A Validation Study

ABSTRACT Purpose Studying patients with bacteremia in real‐world data often requires using microbiologic data to confirm bacterial growth and species. When microbiologic data are unavailable, pathogen‐specific diagnostic codes may be used to classify the bacteremia type. We devel...

T cell–intrinsic AIM2 exacerbates lung inflammation in OVA-LPS- and HDM-induced asthma models

Asthma is a heterogeneous inflammatory airway disease characterized by immune dysregulation, airway hyperresponsiveness (AHR), and excessive immune activation. Although NLRP3 (NOD-like receptor family pyrin domain-containing 3) has been extensively studied in asthma, its role rem...

LINGO1-targeted antibody-drug conjugates improve efficacy and tolerability of antineoplastic therapies in Ewing sarcoma models

We reported LINGO1 as a potential marker on Ewing sarcoma cells that could enable targeted drug delivery, improving treatment effectiveness while reducing side effects.

UNC5B regulates epithelial-to-mesenchymal transition through a SRC-ZEB1 signaling axis to facilitate pancreatic cancer metastasis

Metastatic dissemination is the principal cause of death in pancreatic ductal adenocarcinoma (PDAC), yet the molecular determinants that enable this process remain poorly understood. Here, we identify the axon guidance receptor UNC5B as a central regulator of PDAC metastasis. Usi...