Ümraniye Eğitim ve Araştırma Hastanesi

The Aggregate Index of Systemic Inflammation and Risk of Perforation, Mortality, and Surgery in Ileus

Abstract This article aims to evaluate the relationship between the aggregate index of systemic inflammation (AISI) and the occurrence of perforation, the likelihood of surgical management, and in-hospital mortality in patients with ileus, and to assess its diagnostic performance...

SOFA-2 vs. SOFA and early warning scores for short-term mortality in older adults with sepsis in the emergency department

SOFA-2 was developed to update the SOFA score for contemporary clinical practice, but its performance in older adult emergency department (ED) patients with sepsis is uncertain. We evaluated SOFA-2 for short-term mortality prediction and compared it with SOFA and commonly used ea...

Real-world outcomes of children with first relapsed acute lymphoblastic leukemia treated according to the ALL-IC REL 2016 guideline in Türkiye

Relapsed acute lymphoblastic leukemia (ALL) remains a major challenge in pediatric oncology, particularly where access to modern immunotherapies is limited. This national multicenter study evaluated real-world outcomes of children with first relapsed ALL treated according to the...

SOX17 and TRPS1 in Müllerian, Breast, and Mesothelial Tumors: Tissue-Based Specificity Profiles and Diagnostic Pitfalls in Malignant Serous Effusions

Background Malignant serous effusions may be the first manifestation of an underlying malignancy, and accurate primary-site attribution is essential. However, distinguishing Müllerian carcinoma, breast carcinoma, and mesothelioma in effusion cytology remains a challenge because o...

Epidural Electrical Stimulation Within an Integrated Rehabilitation Pathway for Traumatic Cervical Spinal Cord Injury: Safety and 12-Month Functional Outcomes

Background/Objectives: Epidural electrical stimulation (EES) is an investigational, off-label neuromodulation strategy used adjunctively with rehabilitation in chronic spinal cord injury (SCI), but safety and longitudinal functional data specific to traumatic cervical SCI remain...

Predictive value of the heterogeneity index in assessing treatment response using 18F-FDG PET/CT in locally advanced and advanced lung cancers.

OBJECTIVE: F-FDG) positron emission tomography/computed tomography (PET/CT)-based parameter to estimate this variability. This retrospective single-center study evaluated the predictive value of HI for treatment response in patients with locally advanced and advanced lung cancer...

Real-World Outcomes of Second-Line Chemotherapy in Metastatic Urothelial Carcinoma

Second-line chemotherapy is widely used in metastatic urothelial carcinoma after progression on first-line platinum-based therapy, but its independent contribution to survival, as opposed to selection of healthier patients, remains unclear. In this multicenter retrospective cohor...

Prognostic performance of the EHMRG score and the EHMRG-BI model in geriatric acute heart failure

This study aimed to evaluate the prognostic performance of the Emergency Heart Failure Mortality Risk Grade (EHMRG) score for predicting 30-day mortality in geriatric patients with acute heart failure (AHF) and to determine whether incorporating brain natriuretic peptide (BNP) an...

Epidemiology and its results in hip fractures followed in postoperative intensive care

The global proportion of individuals aged ≥ 65 years is approximately 9%, and hip fractures (HFx) represent one of the most common and serious injuries in this population. This study retrospectively evaluated postoperative intensive care unit (ICU) admissions among patients with...

Real-world outcomes of second-line therapy in advanced thymic carcinoma: a multicenter Turkish Oncology Group (TOG) study

Abstract Background Thymic carcinoma (TC) is a rare and aggressive malignancy with limited evidence guiding second-line treatment after prior systemic therapy. We evaluated real-world outcomes of second-line systemic therapy in a multicenter cohort. Methods Adults with unresectab...

Comparative Performance and Utility of Large Language Models in Generating Psychological Screening Checklists for Bariatric Surgery

Background: Psychological assessment is essential for bariatric surgery candidacy but remains inconsistent and time-consuming. This study compared three large language models (LLMs) in generating structured psychological screening checklists to support standardized preoperative e...

Efficacy of Beta-Aminopropionitrile, Contractubex®, Nigella sativa Oil, Aloe Vera Oil, and Soybean Oil in Preventing Postoperative Adhesions in an Experimental Thyroidectomy Model

<title>Abstract</title> Background/Aim: Adhesions in reoperative thyroid surgery lead to prolonged operation times and an increase in postoperative complications. The use of anti-adhesive agents during the initial surgery may reduce the incidence of recurrent laryngeal nerve inju...

COMPARISON OF AUGMENTED REALITY AND COMPUTED TOMOGRAPHY IN THE ASSESSMENT OF INTRA-ARTICULAR DISTAL HUMERUS FRACTURES ACCORDING TO SPECIALIST EXPERIENCE

Objective: The aim of this study was to compare augmented reality (AR) and computed tomography (CT) in terms of diagnostic accuracy (DA), response time (RT), and surgical planning time (SPT) during the assessment of intra-articular distal humerus fractures by orthopedic and traum...

Integrated Prognostic Stratification After Perioperative FLOT in Gastric and Gastroesophageal Junction Adenocarcinoma: A Multicenter Real-World Study

Background/Objectives: Outcomes after perioperative FLOT for gastric and gastroesophageal junction adenocarcinoma remain variable, even among patients treated with curative intent. Although postoperative pathological findings are central to risk assessment, they do not fully capt...

Impact of adjuvant endocrine therapy on disease-free survival in early triple-positive breast cancer: a multicenter retrospective cohort study of the Turkish oncology group

Triple-positive breast cancer (TPBC), characterized by concurrent ER, PR, and HER2 positivity, poses unique therapeutic challenges due to ER–HER2 crosstalk. The optimal adjuvant endocrine therapy in TPBC patients receiving anti-HER2 regimens remains poorly defined. This multicent...