Umm al-Qura University

Spatially-integrated Ancestry Polygenic Risk Mapping for Diabetes: A Geographic-adjusted Genetic Scoring Framework

Abstract Background: Conventional polygenic risk scores (PRSs) often fail to capture geographic and ancestry-specific variation, limiting their predictive accuracy in admixed and globally diverse populations. This study aims to develop a spatially-aware PRS (SA-PRS) framework tha...

Synthesis, modelling, biological activity of new thiophene hybridized with pyrazole, and/or pyridine analogues as potential DNA gyrase and topoisomerase IV inhibitors

Promoted by the well-established, valuable biological activity of thiophene-based hybrids, the study displayed the synthesis of two series of thiophene-pyrazole hybrids, 7a-c and thiophene-pyridine hybrids 9a-c, via reacting arylhydrazone with halogenated reagents and nucleophili...

Resolution of severe autoimmune hemolytic anemia and thrombocytopenia associated with Plasmodium vivax malaria without corticosteroid therapy: A case report

Rationale: Autoimmune hemolytic anemia is a rare but potentially life-threatening complication of Plasmodium vivax malaria. Most reported cases required corticosteroid therapy in addition to antimalarial treatment. Patient concerns: We report the case of a 28-year-old Ethiopian m...