Institution
UK Dementia Research Institute
Recent research
- Society & EconomicsOpen access
Are different consumer sleep technologies measuring the same essential aspects of sleep?
Abstract Study objectives Consumer sleep technologies (CSTs) enable low-burden longitudinal sleep monitoring, and their output measures are often interpreted as equivalent to polysomnography (PSG) measures. We applied a measurement reliability-aware approach to determine whether...
- Health & MedicineOpen access
( Int J Gynaecol Obstet . 2026 Mar;172(3):1491–1500. doi:10.1002/ijgo.70421) A prospective observational study explored whether neurofilament light (NfL), a marker of neuronal injury, can be reliably measured in umbilical cord blood and whether it is associated with nonreassuring...
- BiologyOpen access
We developed a high-content screening to investigate how Alzheimer’s disease (AD) genetic risk factors may affect synaptic mechanisms in rat primary neuronal cultures. Of the target genes identified, we found that Plcg2 downregulation in mouse dentate gyrus neurons consistently d...
- Health & MedicineOpen access
Abstract Introduction Recent proteomic studies have identified both established and novel proteins in genetic frontotemporal lobar degeneration (FTLD). However, it remains unclear at what point in the disease these proteins deviate from normal levels and how their trajectories re...
- Health & Medicine
Importance: Capturing individual multiple sclerosis (MS) progression is difficult; few studies have evaluated glial fibrillary acidic protein (GFAP) in large longitudinal cohorts with independent validation. Objective: To investigate whether serum GFAP levels and treatment-relate...