UCLouvain

Unlocking the agroecological transition in intensive farming systems

A system-wide transformation of dominant intensive farming and food systems is strongly needed to address their high sanitary, environmental, and social costs. Here we argue that simultaneously addressing lock-ins across the entire food system is essential to enable such a transf...

Villous Architecture in Colorectal Adenomas: Molecular Pathogenesis, Epithelial Plasticity, and Malignant Risk

Villous morphology is routinely used to stratify risk in conventional colorectal adenomas, yet it remains largely interpreted as a visual histological descriptor. This review proposes a different view: villous architecture is a graded, spatially organized epithelial state that li...

Open Borders, Restrained Change: How Group Permeability Shapes Intergroup Evaluations and Social Hierarchy

Building on Social Identity Theory (SIT), the dimensional compensation model (DCM) suggests that people rely on the Big Two dimensions of social evaluation to manage their group identity: members of low (high) status groups compensate their relative lower (higher) standing compet...

Investigating wake reproduction of a model-scale wind turbine: experimental measurements versus large eddy simulation with actuator line

Accurate modeling of wind turbine wakes is essential for understanding turbine performance, wake interactions, and structural loading in wind energy applications. This work presents a combined experimental and numerical investigation addressing key gaps in model-scale wind turbin...

Why Metrics Matter in Thyroid Eye Disease

Importance Advances in the understanding of the pathophysiology of thyroid eye disease (TED) provide an opportunity to use novel, targeted therapeutic agents. However, our capacity to assess the efficacy and indications for the new agents is potentially limited by the clinical me...

Droughts in western Central Europe and associated atmospheric circulation patterns since 1844

Droughts in western Central Europe have major impacts on agriculture, ecosystems, and society, yet their long-term variability and drivers remain poorly understood. This study investigates drought variability over the past 180 years and its link to atmospheric circulation. Three...

Focal and Steerable Temporal Interference Stimulation of the Human Left Posterior Insula: A Proof-of-Concept Validation Using Intracranial Recordings in a Human Cadaver

The insular cortex, especially its posterior subdivision, is a key hub for interoceptive, somatosensory, and nociceptive processing, making it a compelling target for neuromodulation. However, its depth within the lateral sulcus makes it difficult to reach selectively with conven...

Rehabilitation and the post-intensive care syndrome across the recovery continuum: a narrative review

Purpose Improved survival from critical illness has produced a growing population of intensive care unit (ICU) survivors with new or worsened physical, cognitive, and mental-health impairment, defined as post-intensive care syndrome (PICS), and frequent distress among families/ca...

Agricultural drought monitoring with Sentinel-1 cross‑ratio in heterogeneous tropical agriculture: a Mozambique case study

Agricultural drought monitoring is essential for food security in tropical regions where rain-fed agriculture predominates. Operational early warning systems rely primarily on optical vegetation indices, but cloud cover limits their usability during critical growing periods. SAR...

Integrating a pesticide risk indicator into a multi-criteria assessment tool for comparing crop protection scenarios

CONTEXT Chemical pesticides remain central to agricultural productivity but pose well documented risks to human health and ecosystems. While Integrated Pest Management (IPM) offers a more sustainable alternative, its adoption remains limited, partly due to the complex trade-offs...

Amygdala shows heterogeneous atrophy and tauopathy patterns across the AD continuum

Abstract Background Amygdala shows early vulnerability in Alzheimer’s disease (AD), although its substructures have been less studied than hippocampal subfields. Neuropathological evidence suggests that tau pathology affects amygdala subnuclei differentially, yet in vivo characte...

Psychological Profiles of Adolescents About Climate Change Anxiety and Worries: An Application of Latent Profile Analysis

Climate change generates uncertainty and insecurity, shaping human–environment relations and contributing to psychological distress, particularly in the form of worry and anxiety. While moderate levels of worry may foster adaptive responses, elevated worry and anxiety are associa...

Evaluation of the Hydrodynamic Forces on an Isolated Building Induced by a Dam-Break Flow

Abstract Flood-induced forces on buildings are a key concern for designing resilient infrastructure in flood-prone areas. Standard guidelines in several countries provide simplified approaches to account for different types of loads, such as hydrostatic pressure, impact forces fr...

Declines in European bumblebee habitat suitability attributable to climate change

Climate change is increasingly implicated in the decline of insect pollinator populations, which provide critical ecosystem services. Isolating its contribution from other co-occurring environmental stresses remains challenging yet crucial for informing conservation strategies an...

Towards a deep-learning genomic tool for risk stratification and diagnostic support in sporadic ALS

Abstract Background A variety of common and rare genetic factors have been implicated in the development of amyotrophic lateral sclerosis (ALS), and the evidence is that a genetic component is present in most affected individuals. However, our current understanding of ALS genetic...

Sea Level Emulator Intercomparison Project (SLEIP) Phase 1: Assessing emulated multi-century global mean sea level projections

Abstract. Simplified sea level modelling approaches calibrated against reference data, also referred to as sea level emulators, can explore future sea level rise and associated uncertainties with low computational cost. Here, we introduce the Sea Level Emulator Intercomparison Pr...

Full event interpretation with machine-learning-based particle-flow reconstruction in the CMS detector

Abstract The particle-flow (PF) algorithm constructs a global description of each particle collision by producing a comprehensive list of final-state particles, and is central to event reconstruction in the CMS experiment at the CERN LHC. The existing PF implementation relies on...

Baseline gut microbiome and metabolome profiles predict weight loss after a structured lifestyle intervention

Abstract Background Obesity remains a global health challenge, and responses to lifestyle-based weight-loss interventions are heterogeneous. Here, we evaluate a one-year structured lifestyle program in 50 adults with obesity (mean BMI 42 ± 7.0 kg/m 2 ), integrating clinical, micr...

Differential regulation of the proliferative and autophagic responses in murine and human pancreatic cancer cells

Pancreatic ductal adenocarcinoma (PDAC) cells rely on autophagy to adapt to microenvironmental stress. In our recent work, we showed that baseline autophagy flux levels shape the proliferative capacity of human PDAC cells. Here, we extend these findings by demonstrating that low...

Integrating planetary boundaries into energy system optimisation models for absolute environmental sustainability assessment: a methodological framework

Abstract Transforming energy systems to address climate change must avoid shifting burdens to other planetary boundaries. Yet most energy models still focus primarily on greenhouse gas reduction, often neglecting broader life-cycle impacts on critical Earth-system processes. This...