TUM Klinikum

Distinct contributions of expertise and automatization to higher dual-task performance: A cognitive–motor dual-task study in pianists

Abstract Dual-task studies consistently find that experts are better at performing two tasks at the same time than non-experts. Usually, this effect is explained by the high degree of skill automatization in experts, given that skills become increasingly automatized during later...

Reported practice patterns in the use of local antibiotics for fracture-related infection among SICOT respondents: an international survey

Abstract Background Local antibiotics are increasingly used in the management of fracture-related infection (FRI), but international practice patterns regarding their indications, antibiotic selection, and application methods remain heterogeneous and insufficiently standardised....

Comprehensive profiling of brain dynamics during anesthesia across phylogeny

Abstract The behavioral effects of anesthetics are highly conserved across species, hinting at shared and fundamental underlying mechanisms. Here we compile a dataset of multiscale neural activity during wakefulness and anesthesia, encompassing human, macaque, marmoset, mouse, ze...

Introducing FRAM as a tool for surgical process modeling: a case study for understanding surgical scheduling complexity

INTRODUCTION: Surgical processes are inherently variable leading to unexpected delays and cancellations. Due to inefficient and outdated processes, there is a need to understand and improve potential bottlenecks. However, traditional surgical process models (SPMs) focus on intrao...

Identification of a Conserved Temporal Molecular Response Signature to CDK4/6 Inhibition Through Multi-Omics Integration Across Cancer Cell Lines

Treatment of metastatic breast cancer with CDK4/6 inhibitors in combination with hormone ablation is the current first-line standard of care for this indication, and the therapeutic activity of these inhibitors has been demonstrated in various tumor entities. However, the efficac...

Nanoparticle Behavior in the Body: Biochemical, Pharmacological and Cellular Aspects

The behavior of nanoparticles (NPs) in the body is a complex, multilevel process governed by a cascade of physicochemical and biological interactions. At the molecular level, these processes include protein adsorption and formation of the biomolecular corona, ion release, and sur...

Upfront surgery vs. neoadjuvant therapy in pancreatic cancer with venous involvement: a multicenter retrospective analysis

Abstract Introduction The benefits of neoadjuvant therapy (NAT) for pancreatic cancer (PC) with portal venous involvement remain debated. This study aimed to compare the short- and long-term outcomes of surgery with or without NAT in patients with PC with suspected venous involve...

RCC-AID: Renal Cell Carcinoma AI Dataset for Medical Imaging Research

Contrast-enhanced computed tomography (CT) is central to the diagnosis, staging, and follow-up of patients with renal cell carcinoma (RCC). As artificial intelligence research into computer-aided solutions continues to grow, the need for curated and annotated datasets becomes inc...

Evaluation of visual guidance techniques for augmented reality-supported assembly tasks in the medical context

Abstract Handling manual assembly tasks is a crucial part of everyday life. Especially with surgical instruments, proficient handling is critical for flawless workflows, efficiency, and overall patient safety. Markerless object pose estimation and augmented reality (AR) visualiza...

Long‐Term Clinical Outcomes of Arthroscopic Suture Anchor Fixation of Bony Bankart Lesions at a Mean 18‐Year Follow‐Up

PURPOSE: To evaluate shoulder stability and function at long-term follow-up after arthroscopic single-row suture anchor fixation of bony Bankart lesions. METHODS: This was a retrospective, single-center study. Patients with anterior glenoid rim fractures after traumatic shoulder...

Impedance-based tracking of a cochlear implant electrode reliably detects successful array insertion

Abstract Introduction Continuous impedance measurements during cochlear implantation have been hypothesized to provide a reliable indication if the electrode is inside or outside the cochlea. Therefore they provide a valuable feedback mechanism for successful insertion to the sur...

Assessment of emphysema with simulated low-dose dark-field radiography

Abstract Objective Dark-field radiography allows the visualization of lung tissue changes associated with pulmonary emphysema. Simulations were used to investigate the impact of radiation dose reduction on the diagnostic accuracy of emphysema detection. Materials and methods Dark...

MRI severity of common extensor origin damage associated with prior glucocorticoid injection in chronic lateral epicondylitis: a retrospective multicenter analysis

Abstract Background Lateral epicondylitis (LE) is a degenerative tendinopathy of the common extensor origin (CEO). Although local glucocorticoid injections are widely used for symptom relief, concerns exist regarding their potential adverse effects on tendon structure. This study...

Brugada Syndrome in the Pediatric Population: Diagnostic Challenges and Clinical Outcome—Results of the German Multicenter Study COGIA

ABSTRACT Introduction Diagnosis and treatment of children and adolescents with suspected Brugada syndrome (BrS) is challenging. Aim of the study was to evaluate the applicability of current diagnostic criteria for pediatric patients with suspected BrS in the German multicenter st...

Evidence-based recommendations for advancing the chronic pelvic pain syndrome management by the paradigm change from reactive symptom suppression to proactive 3PM-guided patient-centered care

Abstract Chronic pelvic pain syndrome (CPPS) encompasses a heterogeneous group of debilitating conditions including interstitial cystitis/bladder pain syndrome (IC/BPS), chronic abacterial prostatitis, endometriosis, and pelvic congestion syndrome, among others. Despite advances...

Correlation of [ 68 Ga]Ga-RAYZ-8009 PET/CT Uptake with Immunohistochemical Glypican-3 Expression in Hepatocellular Carcinoma: A Proof-of-Target Study

Glypican-3, a cell-surface proteoglycan, is overexpressed in most hepatocellular carcinomas (HCCs). Recently, the glypican-3–targeted PET tracer [68Ga]Ga-RAYZ-8009 was shown to enable noninvasive detection of HCC. This retrospective analysis evaluates the correlation between tumo...

CREM Marks TCR-Driven T-Cell Activation and Associates with Favorable Prognosis in Papillary Thyroid Carcinoma: A Single-Cell and Bulk Transcriptomic Study

Although papillary thyroid carcinoma (PTC) is widely considered an immunologically cold tumor, detectable T-cell infiltration can influence disease progression in selected patients. Previous bulk analyses have linked cAMP-responsive element modulator (CREM) expression to a favora...

Paediatric therapeutic development workshop on osteosarcoma

The fourth Paediatric Therapeutic Development Workshop focused on osteosarcoma, the most common primary bone cancer in children and young adults. Current treatment of osteosarcoma comprises surgery and chemotherapy. Outcome has shown very little improvement over the last four dec...

A systematic review and Meta-Analysis: Exploring the efficacy of self-managed treatments for Temporomandibular Disorders (TMD): The role of home exercise and digital therapies

Temporomandibular disorders (TMD) are highly prevalent and frequently associated with chronic pain and functional impairment, forming part of the diagnostic spectrum in cranio-maxillofacial surgery. Scalable, self-managed interventions - including home-exercise programs, psychoed...

Efficacy and safety of concomitant catheter ablation and left atrial appendage closure compared to catheter ablation only – a meta-analysis

Abstract Background Atrial fibrillation (AF) carries a substantial ischemic stroke risk originating predominantly from the left atrial appendage (LAA). Catheter ablation (CA) is the most effective rhythm-control strategy, while percutaneous LAA closure (LAAC) provides mechanical...