Trinity College Dublin

A general physiologically driven representation of leaf turnover in grasslands in the QUINCY land surface model (revision: 974a6b7f)

Abstract. Terrestrial vegetation plays an important role in shaping the Earth's climate due to its control on the global carbon cycle. Understanding and predicting vegetation phenology and biomass turnover into soil organic matter is therefore of great importance for our understa...

Predicting SILENT after lithium poisoning: a multicenter cohort study and pragmatic risk stratification model

INTRODUCTION: The Syndrome of Irreversible Lithium-Effectuated Neurotoxicity (SILENT) is a rare but potentially devastating complication of lithium poisoning. Current evidence rests on case reports and small series, leaving its true incidence, risk factors, and follow-up tools po...

Wind shear severity regimes and multi-step forecasting at Hong Kong International Airport: evidence from the central runway 07C/25C

Wind shear is a critical meteorological hazard in aviation, especially during takeoff and landing, where rapid changes in wind speed and direction can affect lift and airspeed, compromise aircraft performance, and threaten safety. Existing studies predominantly focus on single-ho...

Fast Hydrogel Micro‐Actuators Driven by Electric Fields

ABSTRACT Electrically‐driven hydrogels are crosslinked, charged polymer networks that can deform in an electric field, prompted by osmotic pressure changes. To date, such actuators generally suffer from sluggish response time, with equilibrium actuation times ranging from minutes...

Technology and the future of qualitative data analysis

The entanglement between technology and methodology in qualitative research has largely been overlooked in management and organization studies (MOS). In this paper, we rectify this inattention, proposing that the way we analyze qualitative data be viewed as a socio-technical prac...

Morphology-Based Surgery for Chronic Pancreatitis Across Europe: Toward the Next Generation of Unified Guidelines

OBJECTIVE: To evaluate the use and impact of current surgical guidelines for chronic pancreatitis (CP) across Europe. SUMMARY BACKGROUND DATA: Current guidelines recommend morphology-based surgery for CP, but international studies evaluating their use and impact are lacking. METH...

Decomposition of wastewater sources in England

Abstract The flow arriving at a wastewater treatment plant mixes municipal sewage, rainfall, soil moisture and groundwater, yet is routinely interpreted as if its composition were fixed. Despite the uncertainty this introduces to any case where the signal is used, from combined s...

Augmentative and Alternative Communication and Language: Some Old and New Urgent Issues

Some children struggle with speech development and a small minority never achieve intelligible speech. This review explores research on the use of augmentative and alternative communication (AAC) to support their development of communication and language. There is no generally ac...

Reproducible human reward imaging phenotypes exhibit differential sensitivity to dopamine D2 receptor antagonism

Abstract Human reward processing varies along cue-centric and outcome-centric axes, but a reproducible mechanistic account of individual variation in incentive salience attribution has been lacking. Using fMRI across five cohorts (N-total=1,251; N1=890; N2=245; N3=34; N4=48; N5=3...

Towards a deep-learning genomic tool for risk stratification and diagnostic support in sporadic ALS

Abstract Background A variety of common and rare genetic factors have been implicated in the development of amyotrophic lateral sclerosis (ALS), and the evidence is that a genetic component is present in most affected individuals. However, our current understanding of ALS genetic...

Multidisciplinary Rehabilitation Following Upper Gastrointestinal Cancer Surgery (RESTORE II)

Objective: RESTORE II compared in an RCT the impact of a 12-week multidisciplinary rehabilitation program versus standard care (SC) on cardiorespiratory fitness and physical function in patients postupper gastrointestinal (UGI) oncologic surgery. Summary of Background Data: The v...

Blood-based biomarkers of Alzheimer’s disease and neurodegeneration in an indigenous African cohort using both Simoa and NULISA platforms

Background: In low- and middle-income countries, Alzheimer's disease and related dementias (ADRD) constitute a growing public health burden. Indeed, the lack of awareness and easy screening tools, such as blood-based biomarkers, leaves many patients undiagnosed. In this study, we...

Benchmark Brown Dwarfs as Chemical Laboratories: Linking System Bulk Properties to Atmospheric Retrievals

Abstract We present the first atmospheric retrieval analysis of two compositional benchmark mid-L dwarfs – SDSSJ141659.78+500626.4 and GJ 499 C – using the Brewster retrieval framework, where the wide benchmark nature of these systems provides independent constraints on age and b...

Invasive candidiasis in the Intensive Care unit: diagnostic stewardship, source control, and precision antifungal therapy

INTRODUCTION: Invasive candidiasis remains one of the most challenging infections in the intensive care unit (ICU) because diagnosis is complicated by nonspecific clinical manifestations, frequent colonization, altered host immunity, complex anatomical sources and unstable pharma...

High-grade serous ovarian cancer is associated with increased TP53 mutation burden in uterine lavage

High grade serous ovarian cancer (HGSC) has low survival partly due to the lack of methods for detection, diagnosis, and risk prediction. TP53 mutations, which drive HGSC, are found in gynecological tissues as the result of somatic evolution, but it is unknown whether an excess o...

Cognitive vergence and pupillary responses as functional oculomotor signatures to differentiate AT(N) biological profiles in older adults with mild cognitive impairment

Abstract The locus coeruleus (LC), the earliest site of tau accumulation in Alzheimer’s disease, directly influences pupillary and vergence oculomotor systems. Whether task-evoked oculomotor dynamics can non-invasively differentiate AT(N) profiles, A+T+ (biological Alzheimer’s di...

From six to twelve months: how extending the statutory prognostic threshold affected fast‑tracked end-of-life benefit access in England and Wales

Abstract Background To evaluate the impact of the 2022 change in prognostic eligibility criteria for the Special Rules for End of Life (SREL) pathway, from an expected death within 6 months to within 12 months, on the number and characteristics of awardees for fast-tracked financ...

Relaxation Polyamorphism of Rosuvastatin and Physicochemical Characterisation of a Rosuvastatin–Carvedilol Co-Amorphous System

Objective: In this study, the solid-state properties of two amorphous forms of rosuvastatin calcium (ROS) and co-amorphous systems of rosuvastatin with carvedilol (CAR) were investigated. Methods: The studied systems were investigated using TGA, DSC, TMDSC, PXRD, SAXS, SSNMR, and...

How Norms Depend on the Presence and Status of Observers: The Relational Contingency of Everyday Behaviors in 90 Societies

Norms are fundamental to social life, but basic questions about how they are affected by social context remain. Specifically, how do normative constraints depend on the presence and status of observers, and how do such relational contingencies vary across cultures? Using data fro...

A Comparative Corpus Study of Epistemic Culture and Discourse in Computer Science, the Humanities, and the Digital Humanities

This article advances understanding of the interdisciplinary components of the digital humanities, and how this hybrid field relates to some of its contributing epistemic traditions. It builds its approach by drawing upon recent empirical work on the values expressed within AI re...