Tribhuvan University

Identification of a natural product inhibitor of SARS-CoV-2 Mpro through integrated virtual screening, DFT, and molecular dynamics simulations

Abstract The emergence of vaccine-resistant SARS-CoV-2 variants demands the development of novel antivirals targeting conserved viral proteins, like the main protease (M pro ). For expediting drug discovery, CADD approach of integrating different computational tools have been emp...

Association of multiple micronutrient powders, vitamin A supplementation and deworming with anaemia among children aged 6–59 months in Nepal: analysis of the 2022 Nepal Demographic and Health Survey

Background Childhood anaemia remains a substantial public health challenge in Nepal, affecting a large proportion of children despite the implementation of national intervention programmes, including multiple micronutrient powders (MNPs), vitamin A supplementation and deworming....

Historical Trend and Future Projection of Summer Temperature Extremes in Nepal

ABSTRACT The monsoon dominated climate along with the complex topographic gradient of Nepal, make it highly sensitive to changes in summer temperature extremes, yet nationwide evidence combining observations and projections remains limited. This study examines historical and futu...

Comparative field and laboratory efficacy of botanical and mineral-based treatments against Artona chorista in large cardamom in eastern Nepal

Large cardamom ( Amomum subulatum Roxb.) is an economically important cash crop of the eastern Himalayas; however, its productivity is severely constrained by the leaf-eating caterpillar Artona chorista , a major defoliating pest in cardamom-growing regions of Nepal. Although non...

The impact of authenticity and transparency of eco-labeling in cosmetic product purchase decision

The research examines relationship between the perceived green authenticity and eco-label transparency of cosmetic products, and whether the green trust mediates these connections based on the principles of Signaling Theory and Commitment-Trust Theory. The data has been collected...

Hydro-climatic extremes: trends, anomalies and implications for urban water management

ABSTRACT Assessing the trends and anomalies of hydro-climatic extremes for improving the urban water managment. Intensifying hydrological and climatic risks are threatening infrastructures and services; therefore, understanding anomalies in hydro-climatic extremes (HCE) is impera...

Policy intervention for antimicrobial resistance mitigation in Nepal: a scoping review of statutory and policy instruments

Antimicrobial resistance (AMR) is an urgent global health threat, and Nepal faces rising challenges across human, animal, and environmental health sectors. Although Nepal has multiple statutory and policy instruments related to medicine, public health, animal health, food safety...

Sustainable soil stabilization: a comprehensive review of green technologies, industrial by-products, and bio-mediated methods

Abstract Soil stabilization is fundamental to geotechnical engineering, yet traditional cement- and lime-based methods impose significant environmental burdens through high energy consumption and CO 2 emissions. This review systematically analyzes sustainable stabilization techno...

Exploring cognitive–institutional alignment in poetry comprehension: a grade 8 case study in Nepal

Poetry is persistently perceived as more difficult than narrative prose among ESL/EFL learners, yet whether this difficulty is intrinsic to the genre or structurally mediated remains undertheorised. This study examined whether Grade 8 ESL/EFL learners’ poetry difficulty may be as...

Cascading Crises, Bounded Warnings, and Climate Injustice: Anatomy of The 2026 Bhote Koshi - Trishuli Catastrophe in Nepal

The catastrophic Bhote Koshi–Trishuli disaster of August 2026 has brought the unequal geography of climate risk into sharp focus (National Disaster Risk Reduction and Management Authority [NDRRMA], 2026). Nepal, a country with a relatively small contribution to global greenhouse...

Data-Driven Machine Learning for Predicting Seismic Response and Fundamental Period of Masonry-Infilled Reinforced Concrete Frames

Accurate prediction of seismic response and fundamental vibration period (T) is essential for the robust seismic design of reinforced concrete moment-resisting frames, although masonry infill walls are often neglected. This study developed a hybrid machine learning framework usin...

Dual antidiabetic potential of arjunglucoside I and arjunetin from Terminalia chebula via modulation of insulin- and gluconeogenesis-related responses

A deciduous tree belonging to the Combretaceae family, Terminalia chebula Retz. has a long history of traditional use in diabetes management. However, it is not fully understood how the extract of T. chebula exerts the antidiabetic effects. To identify the constituents responsibl...

Multitarget Pharmacological Evaluation of Pouzolzia rugulosa: Phytochemical Characterization, Antioxidant, Antimicrobial, Antidiabetic, and Anticancer Activities

Abstract Medicinal herbs are valuable sources of bioactive compounds with diverse therapeutic applications. The genus Pouzolzia is recognized for producing secondary metabolites such as phenolics, flavonoids, and alkaloids, which contribute to various pharmacological properties....

Machine learning-based framework for real-time seismic damage assessment of RC buildings in Nepal

Seismic fragility curves help assess structural damage based on a few structural and ground motion (GM) features. In Nepal, diverse construction practices exist, and current standards require reinforced concrete (RC) buildings to ensure structural integrity under design spectra f...

Machine-learning projections of groundwater storage under climate, land-use, and human-driven changes in Madhesh Province, Nepal

Groundwater is the primary source of water in Madhesh Province, Nepal, yet the province lacks a reliable forecasting framework. This study develops a provincial-scale groundwater forecasting system by integrating satellite-derived groundwater storage (GWS), machine learning, and...

Knowledge and Practices of Biomedical Waste Management Among Health Professionals and Waste Handlers in Hospitals of Kaski Districts of Nepal

BACKGROUND: Biomedical waste management (BWM) is an essential element of health safety and environmental protection. Government of Nepal introduced the Health care waste management guideline-2014; however, its implementation remains inconsistent. OBJECTIVE: To assess knowledge of...

Knowledge and utilization of family planning and safe abortion services among married women of reproductive age in the Raute community of Nepal: A census-based cross-sectional study

Abstract Indigenous and nomadic communities worldwide face disproportionate and persistent barriers to reproductive health services, including family planning and safe abortion. The Raute of Nepal — one of the country’s last nomadic hunter-gatherer groups represent a uniquely mar...

Prevalence and associated factors of nomophobia among the medical and university students of Bangladesh

Abstract Background Nomophobia, characterised by the dread or anxiety of being without access to a mobile phone, has become an increasing behavioural issue among young adults, especially university students. Excessive reliance on smartphones has been linked to psychological suffe...

A cost-effective conventional endpoint PCR assay for HLA-B*13:01 genotyping to guide personalized dapsone therapy in leprosy in low-resource settings

Background Dapsone is a drug used to treat leprosy. Dapsone causes a highly morbid and potentially fatal severe drug hypersensitivity reaction (DHS) in 1–3% of leprosy cases. The allele HLA-B*13:01 is a known genetic risk factor for DHS. However, resource-intensive genotyping met...

The intergenerational transmission of advantage: parental education, out-of-school engagement and mathematics achievement in 81 countries

Parental education predicts academic success, but its transmission is often oversimplified. This study examines how students’ out-of-school engagement, what Bourdieu called internalized family dispositions or ‘habitus’, mediates this relationship for mathematics achievement. Usin...