Tribhuvan University

Dynamic geometric constraints govern covalent feasibility in KRAS G12C ligands

<title>Abstract</title> Covalent inhibition has emerged as an effective strategy for targeting oncogenic proteins, yet successful covalent engagement depends not only on binding affinity but also on the dynamic preservation of productive electrophile–thiol geometry [1,2]. Motivat...

Forensic geotechnical–geophysical investigation of groundwater-driven recurrent slope failure along the Kali Gandaki Road corridor, Lesser Himalayas, Nepal

Recurrent slope failures along Himalayan Road corridors cause substantial infrastructure damage and loss of life, yet systematic forensic investigation of individual failure sites remains rare in Nepal. This study presents an integrated forensic geotechnical–geophysical investiga...

Photoluminescence characterization of nitrogen-doped carbon quantum dots using Theremino-based DIY spectrometer

Theremino Spectrometer is open-source tool that is mainly used for learning and simple optical measurements. This study adapted Theremino to do photoluminescence analysis of N-CQDs. N-CQDs was synthesized using a microwave method with citric acid and urea resulting a solution wit...

Explainable lightweight deep learning architectures for crop anomaly detection using enhanced Grad-CAM and transfer learning

This study improves the interpretability of convolutional neural networks (CNNs) for crop anomaly detection while identifying architectures suitable for deployment on resource constraints edge devices. Six CNNs, including the proposed hybrid, were evaluated across 10 crop species...

Lithological schematization of the Karnali fluvial fan (Nepal’s Terai Arc Landscape) using electrical resistivity tomography as a basis for hydrogeological investigations

Abstract In the Nepalese and Indian Terai Arc Landscape (TAL), protected nature areas are supported by groundwater systems that have remained largely understudied. This study schematizes the lithology of the Karnali fluvial fan located in the Bardia district (Nepal) as a basis fo...

The Street That Forged Them: Poverty, Survival, and Female Solidarity in Pat Barker's Union Street

Pat Barker's first novel, Union Street (1982), is a stark portrait of working-class women in a decaying industrial town in the north of England. Seven linked stories, each centering on a different woman or girl living on or near the same street, form a collective narrative of har...

The Street That Forged Them: Poverty, Survival, and Female Solidarity in Pat Barker's Union Street

Pat Barker's first novel, Union Street (1982), is a stark portrait of working-class women in a decaying industrial town in the north of England. Seven linked stories, each centering on a different woman or girl living on or near the same street, form a collective narrative of har...