Translational Research Institute

Addressing migration-related inequities in health: an expert narrative review of emerging patterns, myths and realities in a rapidly transforming world

Purpose This expert narrative review uses an integrated framework to examine interactions between infectious diseases and non-communicable diseases (NCDs), while challenging prevailing assumptions shaping migrant health narratives and policy. Design/methodology/approach This expe...

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Ovarian cancer is the most lethal gynecological malignancy, due to late‐stage diagnosis, tumor heterogeneity, and lack of biomarkers for early detection. Extracellular vesicles (EVs) in plasma and ascites offer a minimally invasive source of tumor‐derived information, yet their l...

PEG-Heparin hydrogels allow for the assessment of breast cancer tumouroid response to anti-cancer treatment for personalised medicine

Objectives The validation of accurate three-dimensional (3D) models holds significant importance for anti-cancer drug development and screening processes, aiming to minimise the time and resources lost during their development using conventional procedures. Here, we investigated...

Prevalence and Factors Associated With Illicit Drug Use Among Older Australians: A Cross-Sectional Study Using a Nationally Representative Household-Based Survey (HILDA)

Background: Illicit drug use among older adults (aged 45+ years) is increasing globally. Despite the growing impact on older adults, studies examining illicit drug use in this population remain limited. Method: Data were drawn from Wave 21 (2021) of the Household, Income and Labo...

Emergency Department Implementation of Care Models for Individuals Experiencing Family and Domestic Violence and Abuse: A Systematic Scoping Review

Family and domestic violence and abuse (FDVA) is a major public health issue. Emergency Departments (EDs) are critical points of contact: women affected by intimate partner violence attend EDs at triple the rate of unaffected women, and 44% of women killed by a partner presented...

HITH4HIPs: a feasibility trial of hospital in the home after hip fracture

In Australia, as in many other jurisdictions, people with low-trauma hip fractures often stay in hospital for extended periods, even when medically stable, increasing risk of hospital-related complications and increasing healthcare costs. In this context, we sought to determine t...

Appointment adherence, weight reduction, and retention at 9 months in Australian clinical obesity services: a retrospective cohort study

OBJECTIVE: This study aimed to compare demographic, clinical, and early engagement characteristics between participants retained and not retained at 9 months in specialist obesity services. METHODS: This retrospective cohort study analysed 235 records of patients (mean body mass...

Cell‐Type‐Resolved Proteomics Reveals Distinct Immune and Metabolic Programs Between Primary and Recurrent Ascites in HGSOC

ABSTRACT High‐grade serous ovarian carcinoma (HGSOC) frequently recurs after platinum–taxane therapy, yet recurrence‐associated changes within ascites remain unclear. We performed cell‐type‐resolved quantitative proteomics on paired ascites samples collected at primary diagnosis...

Development and Validation of the Melanoma Cancer Awareness Measure

<ns5:p>Background In the UK, the time taken to recognise a melanoma symptom and seek medical attention is the third longest of all cancers. There is no validated measure to assess public awareness of melanoma. We aimed to develop and validate a reliable Melanoma Cancer Awareness...

Issues in the clinical assessment and management of people living with motor neurone disease (MND): a survey of Australian healthcare professionals

Objective: To inform the development of the Australian MND Guideline, this study aimed to identify challenges Australian healthcare professionals (HCPs) face in the clinical assessment and management of people living with MND (plwMND) including where practice varies from evidence...