Tokyo Medical University

Risk of febrile neutropenia in breast cancer chemotherapy despite the prophylactic use of pegfilgrastim: a retrospective analysis

<title>Abstract</title> Background Pegfilgrastim, a long-acting granulocyte colony-stimulating factor (G-CSF), is used to prevent febrile neutropenia (FN) in breast cancer patients undergoing chemotherapy. However, a small subset of patients still develops FN and requires hospita...

Beraprost Attenuates Starvation‐Induced Apoptosis and Protects Feline Endothelial Cells

OBJECTIVES: This study aimed to establish an in vitro model of feline endothelial cells (FECs) undergoing apoptosis when cultured under various nutrient deprivation (starvation) conditions to investigate the protective effects of beraprost and its stereoisomers on endothelial cel...

Terminology for describing the 24-h cycle of physical activity, sedentary behaviour, and sleep: a scoping review

Abstract Background Physical activity, sedentary behaviour, and sleep are three behaviours which occupy the 24-h cycle and interact to influence a multitude of health outcomes. Different terms are currently used to describe these behaviours collectively (e.g., movement behaviours...

Inverse Design of Strongly Localized Topological π Modes in One-Dimensional Nonperiodic Systems

This study investigates the spatial confinement of topological π-modes in one-dimensional chiral-symmetric systems. In conventional periodic and quasiperiodic structures, edge-mode wave functions inevitably penetrate the bulk. To suppress this, inverse design of a potential seque...