Tianjin University of Traditional Chinese Medicine

Effects of repetitive transcranial magnetic stimulation on global cognitive performance and activities of daily living in post-stroke patients: a systematic review and meta-analysis

Background Post-stroke cognitive impairment (PSCI) severely affects patients’ daily living and independence, with limited treatment options. Repetitive transcranial magnetic stimulation (rTMS) shows promise but inconsistencies in reported effect sizes across cognitive domains.Met...

An integrated computational and in vitro framework identifies CTSB and MMP7 as DEHP-responsive candidates in gastric adenocarcinoma

Di(2-ethylhexyl) phthalate (DEHP) is a widespread endocrine-disrupting chemical, but its molecular effects in gastric adenocarcinoma remain incompletely understood. This study integrated network toxicology, multi-cohort transcriptomics, weighted gene co-expression network analysi...

Effects of Yijing decoction on diminished ovarian reserve: associations with mitochondrial function, apoptosis, and the PGC-1α/SIRT3/HIF-1α pathway

Abstract Diminished ovarian reserve (DOR) is a common reproductive disorder that severely impairs female fertility and lacks effective treatments. Protecting granulosa cells (GCs) has emerged as a promising therapeutic strategy. Yijing decoction (YJD), a classical Chinese herbal...

Ergothioneine-Associated Transcription Opposes Conserved Mitochondrial Injury Programs in Proximal Tubules

Acute kidney injury (AKI) is characterized by tubular epithelial stress, inflammation, and metabolic dysfunction, yet the transcriptional programs associated with effective metabolic recovery remain poorly defined. Ergothioneine (EGT) has demonstrated renal and mitochondrial prot...

Estradiol Promotes Tumor Progression in ERα‐Low Endometrial Cancer via the GPER/SphK1 Pathway

ABSTRACT Endometrial cancer (EC) is the most common gynecological malignancy in postmenopausal women. Patients with low estrogen receptor alpha (ERα) expression frequently develop aggressive pathological subtypes and have poor prognosis. The role of estradiol (E2) in ERα‐low EC r...

From screening to gatekeeping: AIGC-detection governance in Chinese university thesis assessment — with a focus on medical education

AI-writing detectors are increasingly embedded in graduation-thesis workflows in Chinese universities. Their use is not only a technical question of classification accuracy. Once detector scores influence review, defence or degree progression, they also allocate evidentiary autho...

Comparative Efficacy of Bone Defect Filler Strategies Following Lesion Debridement for Osteonecrosis of the Femoral Head: A Systematic Review and Network Meta‐Analysis

ABSTRACT Objective This study aimed to systematically review and compare the clinical and radiographic outcomes of different bone defect filler materials following lesion debridement for osteonecrosis of the femoral head (ONFH). Existing evidence on filler materials relies heavil...

Inflammatory Endothelium‐Targeted Carbon Dot Nanozymes for Exogenous Enzyme Supplementation and Synergistic Regulation in Acute Lung Injury

ABSTRACT Acute lung injury (ALI) features vascular endothelial damage, impaired barrier function, and excessive ROS accumulation, which depletes endogenous peroxidases and disrupts redox homeostasis. Transcriptomic comparison between control and ALI model groups verified marked d...

Quality and reliability of cancer pain management information on short-video platforms in China: a cross-sectional content analysis

Short video platforms in China have evolved into primary digital health information channels. Their algorithm-driven ecosystems raise important questions about the quality and dissemination of specialized medical content, such as cancer pain management. This study aimed to assess...

Evolutionary dynamics of the chloroplast genome in Abutilon (Malvoideae, Malvaceae)

The genus Abutilon Mill. (Malvaceae) comprises approximately 178 species distributed across tropical and subtropical regions, many of which hold significant ornamental, economic, and medicinal value; yet its taxonomic classification remains challenging. In this study, six species...

Glutaredoxin 1 facilitates colitis recovery by controlling glutathionylation and activity of STAT6 in M2 macrophages

Inflammatory bowel disease (IBD) is characterized by oxidative stress and intractable inflammation. Current therapeutic strategies are far from satisfactory because of its not fully understood pathogenesis. M2 macrophages can promote inflammation resolution and tissue repair, and...

Comparative chloroplast genomics of 75 Asparagus species reveals conserved genome architecture, gene-specific positive selection, and chloroplast–nuclear phylogenetic discordance

The chloroplast genome offers a compact, maternally inherited resource for resolving evolutionary relationships in plants, yet in Asparagus it has received limited genus-wide attention relative to recent nuclear genomic efforts. Here, we de novo assembled 35 chloroplast genomes:...

Efficacy and Safety Assessment of Upadacitinib for SAPHO Syndrome: A Retrospective Study of 35 Patients

OBJECTIVE: This study aimed to evaluate the efficacy and safety of upadacitinib administered over a short-term period in patients with SAPHO syndrome. METHODS: In this 12-week retrospective observational study, eligible SAPHO syndrome patients diagnosed within the past year and t...

The Heart–Kidney Axis in Heart Failure and Chronic Kidney Disease: Mechanisms, Mediators, and Therapeutic Implications

The heart–kidney axis has emerged as a central framework for understanding the bidirectional interactions that drive cardiorenal syndrome and broader cardiovascular–kidney–metabolic (CKM) disease. However, existing interpretations have often emphasized hemodynamic and neurohormon...

LDL-C–stratified residual lipoprotein(a) and inflammatory risk after acute myocardial infarction among patients with prior statin use

Abstract Background Patients can experience acute myocardial infarction (AMI) despite documented prior statin exposure, indicating persistent residual cardiovascular risk. The prognostic relevance of lipoprotein(a) [Lp(a)] and residual inflammation in this setting remains unclear...

Complete biosynthesis of the clinical agent escin Ia

Abstract Escin Ia is a barrigenol-type triterpenoid specific to Aesculus seeds and is widely utilized in clinical practice for the treatment of cerebral edema, swelling, and venous insufficiency. Here, we fully elucidated its biosynthetic pathway by identifying ten previously unc...

Gaseous Air Pollutant Exposure and Atherosclerosis: A Systematic Study Integrating Multi-Omics and Network Toxicology

Gaseous air pollution is a major environmental risk factor for atherosclerosis, yet the specific molecular networks linking Gaseous air pollution to atherosclerosis are not fully characterized. This study aimed to elucidate how gaseous pollutants drive atherosclerosis using a mul...

Association of baseline and cumulative cholesterol–high-density lipoprotein–glucose index with cardiometabolic multimorbidity: prospective evidence from two cohort studies

Abstract Introduction Cardiometabolic multimorbidity (CMM) is increasingly common and carries substantial clinical and public-health burden. The cholesterol-high-density lipoprotein-glucose (CHG) index has been linked to adverse cardiometabolic outcomes, but prospective evidence...

A quorum sensing antagonist with dual bacterium- and host-directed anti-pathogenic activity against Pseudomonas aeruginosa

Pseudomonas aeruginosa is a major opportunistic pathogen whose clinical management is increasingly compromised by antibiotic resistance and biofilm-associated persistence. Anti-pathogenic strategies that attenuate virulence without inhibiting bacterial growth offer a promising al...

Ambient cold exposure and myocardial infarction risk in Tianjin, China: a distributed lag non-linear analysis

Abstract Background Ambient temperature is an important environmental determinant of cardiovascular health. Although cold exposure has been associated with acute myocardial infarction (MI), evidence on delayed effects and subtype-specific differences remains limited in northern C...