Tianjin University of Traditional Chinese Medicine

Gaseous Air Pollutant Exposure and Atherosclerosis: A Systematic Study Integrating Multi-Omics and Network Toxicology

Gaseous air pollution is a major environmental risk factor for atherosclerosis, yet the specific molecular networks linking Gaseous air pollution to atherosclerosis are not fully characterized. This study aimed to elucidate how gaseous pollutants drive atherosclerosis using a mul...

Complete biosynthesis of the clinical agent escin Ia

Abstract Escin Ia is a barrigenol-type triterpenoid specific to Aesculus seeds and is widely utilized in clinical practice for the treatment of cerebral edema, swelling, and venous insufficiency. Here, we fully elucidated its biosynthetic pathway by identifying ten previously unc...

Association of baseline and cumulative cholesterol–high-density lipoprotein–glucose index with cardiometabolic multimorbidity: prospective evidence from two cohort studies

Abstract Introduction Cardiometabolic multimorbidity (CMM) is increasingly common and carries substantial clinical and public-health burden. The cholesterol-high-density lipoprotein-glucose (CHG) index has been linked to adverse cardiometabolic outcomes, but prospective evidence...

A quorum sensing antagonist with dual bacterium- and host-directed anti-pathogenic activity against Pseudomonas aeruginosa

Pseudomonas aeruginosa is a major opportunistic pathogen whose clinical management is increasingly compromised by antibiotic resistance and biofilm-associated persistence. Anti-pathogenic strategies that attenuate virulence without inhibiting bacterial growth offer a promising al...

Ambient cold exposure and myocardial infarction risk in Tianjin, China: a distributed lag non-linear analysis

Abstract Background Ambient temperature is an important environmental determinant of cardiovascular health. Although cold exposure has been associated with acute myocardial infarction (MI), evidence on delayed effects and subtype-specific differences remains limited in northern C...

Investigating the association between angina and osteoporosis: a 20-year longitudinal cohort study of ELSA

Abstract Background Osteoporosis (OP) is recognized as a major global health threat. Although an association between angina and osteoporosis was established, the underlying mechanisms connecting the two conditions were not clearly elucidated. Therefore, this study aims to systema...

Hydrogen Sulfide-Regulated NF-κB Signaling via Persulfidation: A Review

Hydrogen sulfide (H2S) is an important endogenous gaseous signaling molecule that regulates diverse physiological and pathological processes through protein persulfidation. As a central regulator of inflammation and immune responses, NF-κB signaling is precisely controlled by pos...

Advances in Exosome‐Based Therapy for Cardiovascular Disease: Traditional Chinese Medicine Offering New Avenues for Exosome Functionalization

ABSTRACT Background Cardiovascular diseases (CVDs) remain a leading cause of global mortality and impose a substantial health and economic burden worldwide. Exosomes, as promising endogenous nanocarriers, have emerged as a powerful tool for the prevention and treatment of CVDs. I...